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Carboxymethyl chitosan quaternary ammonium salt derivatives and preparation method thereof

A technology of carboxymethyl chitosan and quaternary ammonium salt is applied in the field of carboxymethyl chitosan quaternary ammonium salt derivatives and preparation thereof, and achieves the effects of easy industrialization, overcoming poor solubility, and expanding application fields

Inactive Publication Date: 2011-01-12
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Carboxymethyl chitosan has good water solubility, but there are few products that further modify carboxymethyl chitosan

Method used

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  • Carboxymethyl chitosan quaternary ammonium salt derivatives and preparation method thereof
  • Carboxymethyl chitosan quaternary ammonium salt derivatives and preparation method thereof
  • Carboxymethyl chitosan quaternary ammonium salt derivatives and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0036] Synthesis of Epoxypropyl Decyl Dimethyl Ammonium Chloride:

[0037] Add 40ml of isopropanol and 18.5g of dodecyldimethylamine into a 100ml one-necked flask, and heat up to 55°C while stirring. Slowly add 9.3 g of epichlorohydrin dropwise to the system with a constant pressure dropping funnel, after the dropwise addition is completed, keep the temperature at 55°C and reflux for 10 hours. After the experiment, distill under reduced pressure to remove unreacted epichlorohydrin and dry to obtain glycidyldecyldimethylammonium chloride.

[0038] Activation of carboxymethyl chitosan:

[0039]Add 25ml of N-methyl-2-pyrrolidone and 0.4g of NaOH powder into a 100ml three-necked flask, stir at 50°C for 1 hour, filter out excess NaOH, and obtain a solvent with a pH of about 9. Add 0.5 g of carboxymethyl chitosan to be activated, and alkalize at 50° C. for 6 hours.

[0040] Quaternization of carboxymethyl chitosan:

[0041] Dissolve 0.56g of glycidyldecyldimethylammonium chlorid...

example 2

[0046] Synthesis of epoxypropyl dodecyl dimethyl ammonium chloride:

[0047] Add 40ml of butanone and 21.3g of dodecyldimethylamine into a 100ml one-necked flask, and heat up to 55°C while stirring. Slowly add 9.3 g of epichlorohydrin into the system dropwise with a constant-pressure dropping funnel. After the dropwise addition, keep the temperature at 55° C. and reflux for 10 hours. Distill under reduced pressure after the experiment, remove unreacted epichlorohydrin, and dry to obtain epoxypropyl dodecyl dimethyl ammonium chloride.

[0048] Activation of carboxymethyl chitosan:

[0049] Add 25ml of isopropanol and 0.4g of NaOH powder into a 100ml three-neck flask, stir at 50°C for 1 hour, filter out excess NaOH, and obtain a solvent with a pH of about 9. Add 0.5 g of carboxymethyl chitosan to be activated, and alkalize at 50° C. for 6 hours.

[0050] Quaternization of carboxymethyl chitosan:

[0051] Dissolve 1.22 g of epoxypropyl dodecyl dimethyl ammonium chloride in 5 ...

example 3

[0056] Synthesis of Epoxypropyl Octalkyl Dimethyl Ammonium Chloride:

[0057] Add 40ml of isopropanol and 15.7g of octaalkyldimethylamine into a 100ml one-necked flask, and heat up to 50°C while stirring. Slowly add 9.3 g of epichlorohydrin into the system dropwise with a constant pressure dropping funnel. After the dropwise addition, keep the temperature at 50° C. and reflux for 8 hours. Distill under reduced pressure after the experiment, remove unreacted epichlorohydrin, and dry to obtain epoxypropyl octaalkyl dimethyl ammonium chloride.

[0058] Activation of carboxymethyl chitosan:

[0059] Add 25ml of N-methyl-2-pyrrolidone and 0.4g of NaOH powder into a 100ml three-necked flask, stir at 50°C for 1 hour, filter out excess NaOH, and obtain a solvent with a pH of about 9. Add 0.5 g of carboxymethyl chitosan to be activated, and alkalize at 50° C. for 6 hours.

[0060] Quaternization of carboxymethyl chitosan:

[0061] Dissolve 1.50g of epoxypropyl octaalkyldimethylammo...

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Abstract

The invention relates to a CM-sephadex-C25 grafted long chain alkyl quaternary ammonium salt macromolecule antibacterial agent and a corresponding preparation method, which comprises dispersing CM-sephadex-C25 in organic solvents as isopropanol, methyl ethyl ketone, N-methyl-2-pyrrolidone and pyrrolidone to graft self-manufactured long chain quaternary ammonium salt on molecular chain in alkali condition, dissolving the product after the reaction via deionized water to be deposited by alcohol, washing and drying to obtain CM-sephadex-C25 modified macromolecule antibacterial agent.

Description

(1) Technical field [0001] The invention relates to a class of carboxymethyl chitosan quaternary ammonium salt derivatives and a preparation method thereof, in particular to the preparation of a carboxymethyl chitosan quaternary ammonium salt derivative with complexation and antibacterial functions and its preparation The method belongs to the field of new materials. (2) Background technology [0002] With the improvement of people's requirements for the quality of life, people also have higher requirements for the antibacterial properties of consumer goods such as clothing, hygiene products, daily necessities, and food packaging. In addition, the proper use of antibacterial products in public places can effectively inhibit the growth of bacteria and prevent the spread and infection of bacteria. Facing the growing demand for antibacterial materials, research on antibacterial materials has also received more and more attention. More safe, efficient and cheap antibacterial a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08
Inventor 孟薇薇唐焕林陈煜谭惠民魏高乐
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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