Pharmaceutical composition containing dexchlorpheniramine and preparation thereof

A technology of dexchlorpheniramine and chlorpheniramine, applied in the field of medicine

Inactive Publication Date: 2008-09-17
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because there is currently no effective treatment for colds, and it has a tendency of self-healing, the purpose of cold treatment is to treat symptoms, reduce symptoms, shorten the course of the disease, and promote early recovery

Method used

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  • Pharmaceutical composition containing dexchlorpheniramine and preparation thereof
  • Pharmaceutical composition containing dexchlorpheniramine and preparation thereof
  • Pharmaceutical composition containing dexchlorpheniramine and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, dexchlorpheniramine maleate+paracetamol tablet

[0017]

[0018] Preparation:

[0019] Pass acetaminophen and microcrystalline cellulose through an 80-mesh sieve, mix well, and set aside; take another appropriate amount of 50% ethanol solution, add dexchlorpheniramine maleate to dissolve, and use this solution as a binder to prepare Soft material, granulate with 24 mesh sieve, dry at 50°C, granulate with 20 mesh sieve, add micropowder silica gel and CMS-Na, mix well, and press a suitable die to form a tablet. If the above-mentioned tablets are coated, coated tablets can be obtained, which can be film-coated tablets, enteric-coated tablets, etc.

Embodiment 2

[0020] Embodiment 2, dexchlorpheniramine maleate + acetaminophen + pseudoephedrine hydrochloride + dextromethorphan hydrobromide chewable tablets

[0021] prescription:

[0022]

[0023]

[0024] Preparation:

[0025] Pass acetaminophen, pseudoephedrine hydrochloride, and dextromethorphan hydrobromide through an 80-mesh sieve, mix them with sorbitol evenly, take an appropriate amount of 50% ethanol solution, add dexchlorpheniramine maleate to dissolve it, and use it as Binder soft material, granulated with 24 mesh sieve, dried at 50°C, granulated with 20 mesh sieve. Add sweet orange powder essence and micro-powder silica gel, mix evenly, and press into tablets to obtain the product.

Embodiment 3

[0026] Embodiment 3, dexchlorpheniramine maleate+pseudoephedrine hydrochloride dispersible tablet

[0027]

[0028] Preparation:

[0029] Pass pseudoephedrine hydrochloride and microcrystalline cellulose through an 80-mesh sieve respectively, and mix them uniformly by the method of equal increments, and set aside; take an appropriate amount of 50% ethanol solution, add dexchlorpheniramine maleate to dissolve it, and use it as an adhesive Soft materials, granulated with a 16-mesh sieve, dried, granulated with a 20-mesh sieve, added other flavoring agents, sweeteners, glidants, disintegrating agents, etc., mixed evenly, and compressed into tablets to obtain the product.

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PUM

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Abstract

The invention discloses a combination containing r-chlorpheniramine, which is formed by the r-chlorpheniramine and the medicine salt and the other or a plurality of active ingredients or pharmaceutical carriers selected from non-steroidal anti-inflammatory drug, ephedrine alkaloids, coffeine, dextromethorphan hydrobromide, carbetapentane citrate, glyceryl guaiacolate, bromhexine hydrochloride, artificial cow-bezoar, amantadine hydrochloride, aminophylline and zinc gluconate. The orally taken preparation developed from the combination comprises granule, tablet, capsule, dispersible tablet, chewable tablet, effervescent tablet, orally disintegrating tablet, buccal tablet, dry suspension and certain solid formulation.

Description

technical field [0001] The invention relates to a composition containing dexchlorpheniramine and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Cold is a kind of acute infectious rhinitis, commonly known as "cold". It is caused by respiratory viruses, among which coronavirus and rhinovirus are the main pathogenic viruses. The virus is excreted and spread from respiratory secretions. When the body's resistance decreases, such as cold, malnutrition, excessive fatigue, excessive smoking, systemic diseases, and chronic diseases of the nose itself that affect the smoothness of the respiratory tract, infections are easily induced. Bacterial infection following the onset of a cold. At the onset of a cold, there is dryness and itching in the nose, sneezing, general malaise, or low-grade fever. Later, nasal congestion, coughing, loss of sense of smell, a lot of watery nose, congestion of the nasal mucosa, edema, a lot of wa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4402A61K31/167A61K31/137A61P11/00A61P31/12
Inventor 严轶东
Owner FUKANGREN BIO PHARMA
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