Sustained-release dropping pill of Tripterygium glycosides and method of preparing the same

Abstract

The invention discloses a pharmaceutical composition which has the effects of dispelling wind and detoxifying, dehumidifying and detumescence, stretching muscles and removing obstruction in collaterals, anti-inflammation and inhibiting the immunity of cells and body fluid, and is used for curing diseases such as rheumatoid arthritis caused by rheumatism, heat, blood stasis and toxic factor blocking, nephrotic syndrome, Behcet's syndrome, leprosy reaction and autoimmune hepatitis, in particular to an oral slow-releasing drop pill preparation prepared by taking tripterygium glycosides as a raw material extracted from Common Threewingnut Root, a Chinese medicine. The invention aims at supplementing the shortcomings of the prior art and providing a slow-releasing drop pill preparation of the tripterygium glycosides. The slow-releasing drop pill of the tripterygium glycosides of the invention is characterized in that: vitamin A, as a stabilizer, and hydrophobic skeleton materials are added into the components adopted by the prior art; the defects of the prior art are effectively overcome, thus ensuring that the medicine does not have obvious change in relevant substance content during effective preservation period, having the advantages of fully releasing of the medicine, controllable releasing time of the medicine, high bioavailability and being applicable to clinic and family use.

Description

technical field [0001] The invention belongs to the technical field of sustained-release pharmacy, and specifically relates to a medicine that has the functions of expelling wind and detoxification, dehumidifying and reducing swelling, relaxing tendons and unblocking collaterals, anti-inflammation, and inhibiting cellular immunity and humoral immunity, and is used for moistening heat stasis due to wind-dampness and preventing toxins and evils. Rheumatoid arthritis, nephrotic syndrome, Behcet's triad, leprosy reaction, autoimmune hepatitis and other diseases caused by stagnation, especially related to the preparation of tripterygium wilfordii extract from tripterygium wilfordii A kind of tripterygium glycosides sustained-release dropping pill medicine formed. Background technique [0002] According to the ministerial drug standard WS 3 - Tripterygium wilfordii polyglycoside tablets prepared by the preparation method given in B-3350-98, is a kind of anti-inflammatory, anti-in...

AI Technical Summary

Problems solved by technology

[0006] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect

In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment

Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

[0007] Chinese patent discloses a kind of Chinese patent tripterygium glycosides dripping pills and its preparation method that the patent No. is 200510090144.1, although the dropping pills prepared by its preparation method have the advantages of fast drug release, high dissolution rate and fast absorption etc. characteristics, but prepared according to its method, some unstable phenomena will occur in long-term storage, that is, aging phenomenon

The analysis may be affected by factors such as the characteristics of the drug itself, the preparation method, and the external environment, which may cause the structure of tripterygium glycosides itself and the crystal form of the substance after forming the drop pill to change, thereby increasing the number of related substances in the drug and making the drug release time longer. Out of control, the bioavailability decreases, therefore, to some extent offset the unique advantages of dripping pills