Injection for curing diarrhea of pig and preparation thereof

Abstract

The invention discloses an injection for the treatment for swine dysentery and a preparation method thereof, which aims at providing the injection for the treatment for swine dysentery that has rapid onset of action for the treatment for swine dysentery and can reduce the times and the dosage of drug administration and reduce the residual drugs which exceed the standards, and the preparation method that has simple process and easy realization. Each 100l injection contains: 0.5 to 10kg of mequindox, 1 to 10kg of lincomycin hydrochloride, 0.2kg of sodium bisulfite, 1.5 to 30kg of sodium salicylate, 0.01Kg of EDTA-2Na, 0.2kg of atropine sulfate and the rest of water for injection. The invention is a compound preparation which combines antimicrobial drugs and antibiotics for usage, the mequindox and the lincomycin hydrochloride are combined for usage, thus adopting double effects, having the dual-killing ability of serpulina hyodysenteriae, reducing the probability of generating the drug resistance of the bacteria and increasing the sensitivity of the serpulina hyodysenteriae; in addition, the atropine sulfate can inhibit the secretion of intestinal digestive glands, so the injection can reduce the water content in the swine intestine during the prevalence period and have rapid onset of action for the treatment for swine dysentery.

Description

technical field

[0001] The invention relates to an injection for treating swine dysentery and a preparation method thereof. Background technique

[0002] Swine dysentery is a common intestinal disease in pigs. It is characterized by catarrhal hemorrhagic inflammation of the large intestine mucosa and then develops into fibrinous necrotizing enteritis. It is clinically manifested as mucus or mucohemorrhagic diarrhea. The pathogen is swine dysentery Treponema, diseased pigs and pigs with bacteria are the source of infection of this disease. The carrier rate is high, and the carrier time can be as long as more than 70 days. In addition to causing death of pigs, it can also reduce feed utilization and hinder growth and development.

[0003] The drugs currently used in the treatment of swine dysentery, such as acemethaquine and lincomycin hydrochloride, etc., due to long-term drug use in recent years, have generally increased the drug resistance of pigs. Satisfactory therapeutic...

Examples

Embodiment 1

[0018] (1) Take 30 L of water for injection, add 1.5 kg of sodium salicylate, stir to dissolve, then add 0.5 kg of acetylmethaquine, and stir until completely dissolved.

[0019] (2) Take 20 L of water for injection, add 0.01 kg of EDTA-2Na, 0.2 kg of sodium bisulfite, 0.2 kg of atropine sulfate, and 10 kg of lincomycin hydrochloride, and stir until completely dissolved.

[0020] (3) Combine the solution prepared in step 1 and step 2, then add water for injection to 100L, stir evenly, keep for 15-20min, and make the injection for treating swine dysentery of the present invention after the liquid is clear.

Embodiment 2

[0022] (1) Take 30 L of water for injection, add 30 kg of sodium salicylate, stir to dissolve, then add 10 kg of acemethaquine, and stir until completely dissolved.

[0023] (2) Take 20 L of water for injection, add 0.01 kg of EDTA-2Na, 0.2 kg of sodium bisulfite, 0.2 kg of atropine sulfate, and 1 kg of lincomycin hydrochloride, and stir until completely dissolved.

[0024] (3) Combine the prepared solution of step 1 and step 2, then add water for injection to 100L, stir evenly, keep for 15-20min, and make the injection for treating swine dysentery of the present invention after the liquid is clear.

Embodiment 3

[0026] (1) Take 30 L of water for injection, add 6 kg of sodium salicylate, stir to dissolve, then add 2 kg of acemethaquine, and stir until completely dissolved.

[0027] (2) Take 20 L of water for injection, add 0.01 kg of EDTA-2Na, 0.2 kg of sodium bisulfite, 0.2 kg of atropine sulfate, and 7 kg of lincomycin hydrochloride, and stir until completely dissolved.

[0028] (3) Combine the prepared solution of step 1 and step 2, then add water for injection to 100L, stir evenly, keep for 15-20min, and make the injection for treating swine dysentery of the present invention after the liquid is clear.

technical field

[0001] The invention relates to an injection for treating swine dysentery and a preparation method thereof. Background technique

[0002] Swine dysentery is a common intestinal disease in pigs. It is characterized by catarrhal hemorrhagic inflammation of the large intestine mucosa and then develops into fibrinous necrotizing enteritis. It is clinically manifested as mucus or mucohemorrhagic diarrhea. The pathogen is swine dysentery Treponema, diseased pigs and pigs with bacteria are the source of infection of this disease. The carrier rate is high, and the carrier time can be as long as more than 70 days. In addition to causing death of pigs, it can also reduce feed utilization and hinder growth and development.

[0003] The drugs currently used in the treatment of swine dysentery, such as acemethaquine and lincomycin hydrochloride, etc., due to long-term drug use in recent years, have generally increased the drug resistance of pigs. Satisfactory therapeutic...

Examples

Embodiment 1

[0018] (1) Take 30 L of water for injection, add 1.5 kg of sodium salicylate, stir to dissolve, then add 0.5 kg of acetylmethaquine, and stir until completely dissolved.

[0019] (2) Take 20 L of water for injection, add 0.01 kg of EDTA-2Na, 0.2 kg of sodium bisulfite, 0.2 kg of atropine sulfate, and 10 kg of lincomycin hydrochloride, and stir until completely dissolved.

[0020] (3) Combine the solution prepared in step 1 and step 2, then add water for injection to 100L, stir evenly, keep for 15-20min, and make the injection for treating swine dysentery of the present invention after the liquid is clear.

Embodiment 2

[0022] (1) Take 30 L of water for injection, add 30 kg of sodium salicylate, stir to dissolve, then add 10 kg of acemethaquine, and stir until completely dissolved.

[0023] (2) Take 20 L of water for injection, add 0.01 kg of EDTA-2Na, 0.2 kg of sodium bisulfite, 0.2 kg of atropine sulfate, and 1 kg of lincomycin hydrochloride, and stir until completely dissolved.

[0024] (3) Combine the prepared solution of step 1 and step 2, then add water for injection to 100L, stir evenly, keep for 15-20min, and make the injection for treating swine dysentery of the present invention after the liquid is clear.

Embodiment 3

[0026] (1) Take 30 L of water for injection, add 6 kg of sodium salicylate, stir to dissolve, then add 2 kg of acemethaquine, and stir until completely dissolved.

[0027] (2) Take 20 L of water for injection, add 0.01 kg of EDTA-2Na, 0.2 kg of sodium bisulfite, 0.2 kg of atropine sulfate, and 7 kg of lincomycin hydrochloride, and stir until completely dissolved.

[0028] (3) Combine the prepared solution of step 1 and step 2, then add water for injection to 100L, stir evenly, keep for 15-20min, and make the injection for treating swine dysentery of the present invention after the liquid is clear.