Preparation and use of I -type collagen artificial tendon, ligaments

A technology for artificial tendons and ligaments, applied in the medical field, can solve problems such as ineffective effects and impossible prevention of adhesions

Active Publication Date: 2012-01-11
许和平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the clinical application of hormones, some biological agents and some surgical treatment methods have no obvious effect, can not effectively regenerate and repair tendons and ligaments, and cannot prevent the formation of adhesions

Method used

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  • Preparation and use of I -type collagen artificial tendon, ligaments
  • Preparation and use of I -type collagen artificial tendon, ligaments
  • Preparation and use of I -type collagen artificial tendon, ligaments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 2: preparation artificial tendon or ligament

[0027] Use 98% pure type I collagen to make a 0.5% collagen suspension, and place it in a vessel containing 6-0 sutures at a low temperature of -100 degrees Celsius to make a 10 mm diameter, 150 mm Long columnar collagen with 200 μm pores Type I collagen artificial ligament or tendon with fixed sutures.

Embodiment 2

[0028] Embodiment 3: preparation artificial tendon or ligament

[0029] Use 98% pure type I collagen to make a 0.5% collagen suspension, and place it in a vessel containing 3-0 sutures at a low temperature of -80 degrees Celsius to make a diameter of 5 mm and a diameter of 125 mm. Long columnar collagen, type I collagen artificial ligament or tendon with a pore size of 125 μm and fixed sutures.

Embodiment 3

[0030] Embodiment 4: Preparation of sheet collagen film

[0031] Type I collagen and chondroitin sulfate with a concentration of 0.5% and a purity of 98% are made into a sheet-like collagen film through a conventional freeze-drying method of 17 decimals.

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Abstract

The invention provides a medical collagen material, a manufacturing method and the application of the medial collagen material. The medical collagen material is provided with a prismatic artificial ligament / hamstring tendon with seams and a platy film provided with dense pores. The artificial prismatic ligament / hamstring tendon is provided with the longitudinal pore that is specifically sized. The artificial prismatic ligament / hamstring tendon and the platy film are used for connecting and wrapping injured sutured part. The medical collagen material has the characteristics of stable structure, good biocompatibility and the ability of degradation and absorption and can reduce or prevent tissue adhesion.

Description

technical field [0001] The present invention relates to the technical fields of medicine, medical biomaterials, and medical tissue engineering, and in particular to an artificial tendon and ligament built-in that can be replaced after tendon and ligament damage to regenerate normal tendon / ligament tissue. At the same time, it provides the preparation and application of an artificial tendon and ligament compound for preventing postoperative tissue adhesion. Background technique [0002] At the end of the 20th century, with the rapid development of holistic medicine, cell biology, molecular biology, genetics and tissue engineering also continued to progress and develop. Biomaterials with good properties are also rapidly discovered and utilized. The rapid rise of tissue engineering in clinical medicine in recent years proves this point. Tissue engineering products using type I collagen as a scaffold for tissue repair and regeneration have achieved remarkable development and a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/08A61L27/24
Inventor 许和平
Owner 许和平
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