A detection kit capable of early and accurate evaluation of liver function

Abstract

The invention provides a detection kit capable of early and accurate evaluation of liver function, that is, a paracetamol and acetaminophenethyl ether chromatographic-spectrophotometric detection kit and its preparation and application. The kit is composed of a chromatographic column, a desorption solution, a hydrolyzate, water and a chromogenic agent, and is characterized in that the chromatographic column is filled with fillers capable of adsorbing acetaminophen and acetaminophenethyl ether; the desorption solution is 35% ethanol; The liquid is 2N hydrochloric acid; the water is double-distilled deionized water; the chromogens are 0.1% W / V 1,2-naphthoquinone-4-sodium sulfonate test solution, 1N NaOH and 1N Na2CO3 test solution respectively. The filler is selected from activated carbon, spherical activated carbon, carbon fiber, vinyl resin, acrylic resin, styrene resin and polyurethane resin, and LMHS 180 resin. The kit is easy to operate, reliable in determination results, capable of simultaneously determining the contents of acetaminophen and acetaminophenethyl ether in pharmaceutical preparations or biological samples, and has clinical practical value.

Description

technical field [0001] The invention relates to the technical field of medical detection reagents, and relates to a detection kit capable of early and accurately evaluating liver function, that is, acetaminophen and phenacetin chromatography-spectrophotometry detection kit and its Preparation and uses. Background technique [0002] In clinical work, I often encounter some patients who were only carriers of hepatitis B virus in the past, and all examinations related to the liver are normal. During the physical examination, as soon as it was found, it was liver cirrhosis or even liver cancer. In some patients with fatty liver, long-term drinking or chronic liver disease, histological or imaging examination shows that the tissue structure of the liver has been obviously destroyed, but the liver function test is normal. Once some patients undergo liver surgery or interventional therapy, severe liver failure often occurs. [0003] In my country, chronic liver disease is a comm...

AI Technical Summary

Problems solved by technology

It mainly includes: (1) An in vivo model for studying extrahepatic metabolism was established, which solved the problem that in vivo experiments could not be used to demonstrate extrahepatic metabolism in the past

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