Combination therapy wherein a serotonin reuptake inhibitor is used

A technology for serotonin reuptake and compounds, used in testing pharmaceutical preparations, combinatorial chemistry, chemical libraries, etc.

Inactive Publication Date: 2009-02-04
H LUNDBECK AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Second, sexual dysfunction is a common side effect of all SSRIs
Their hypothesis focuses on the effect of SSRIs on the controlled-release somatoreceptor (5-HT 1A ) to limit the release of 5-HT in the terminal regions and thus limit the inhibition of 5-HT uptake in those regions

Method used

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  • Combination therapy wherein a serotonin reuptake inhibitor is used
  • Combination therapy wherein a serotonin reuptake inhibitor is used
  • Combination therapy wherein a serotonin reuptake inhibitor is used

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0138] Materials and methods

[0139] animal

[0140] Experiments were performed using male albino mice (285-320 g; Harlan, Zeist, The Netherlands) derived from the Wistar strain. After the operation, the rats were individually housed in plastic cages (35x35x40 cm) with food and water ad libitum. Animals were maintained on a 12h light schedule (lights on at 7:00 am). The experiments were consistent with those described by Helsinki and confirmed by the Animal Care Committee of the Faculty of Mathematics and Natural Sciences of the University of Groningen.

[0141] drug

[0142] The following drugs were used: citalopram hydrobromide, 2-hydroxysaclofen, CGP46381 (Lundbeck A / S, Copenhagen, Denmark), Phaclofen, and (+)-picoclofen (Sigma, St Louis, USA).

[0143] Operation

[0144] Microdialysis of brain serotonin levels was performed with a domestically produced type I-probe made of polyacrylonitrile / sodium methanesulfonate copolymer dialysis fibers (i.d. 220 μm, o.d. 0.31 μm,...

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Abstract

The invention relates to the use of a compound, which is a serotonin reuptake inhibitor, and another compound, which is a GABAB receptor antagonist, inverse agonist or partial agonist for the preparation of a pharmaceutical composition for the treatment of depression, anxiety disorders and other affective disorders, such as generalized anxiety disorder, panic anxiety, obsessive compulsive disorder, acute stress disorder, post traumatic stress disorder and social anxiety disorder, eating disorders such as bulimia, anorexia and obesity, phobias, dysthymia, premenstrual syndrome, cognitive disorders, impulse control disorders, attention deficit hyperactivity disorder, drug abuse or any other disorder responsive to serotonin reuptake inhibitors.

Description

[0001] This application is a Chinese patent application (National Application No. 03814438.7, International Application No. PCT / DK2003) filed on June 19, 2003 for an invention titled "Combined Therapy Using 5-HT Reuptake Inhibitors" / 000412) divisional application. technical field [0002] The present invention relates to serotonin reuptake inhibitors and GABA B Combinations of receptor antagonists. Accordingly, the present invention relates to certain compounds and to compounds having serotonin reuptake inhibitory activity and GABA for use in the treatment of depression and other affective disorders. B Compositions of compounds with antagonistic, partial agonistic or inverse agonistic activity. Combined serotonin reuptake inhibition and GABA B Antagonism, partial agonism or inverse agonism can exist in the same chemical entity or in two separate chemical entities. Background technique [0003] Selective serotonin reuptake inhibitors (hereafter referred to as SSRIs) have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C40B30/04A61K31/662A61K31/343G01N33/15
Inventor A·莫尔克T·I·F·H·克雷默斯S·维利格尔斯
Owner H LUNDBECK AS
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