Method for improving volume of production of griseoviridin with accelerant addition

A technique of griseogreenin and an accelerator, which is applied in the field of increasing the yield of griseogreenin A and increasing the yield of griseocyanin A, and can solve the problems of low fermentative yield of griseogreenin A and the like
CN101402980AInactive Publication Date: 2009-04-08EAST CHINA UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
EAST CHINA UNIV OF SCI & TECH
Publication Date
2009-04-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

A method for improving the yield of viridogrisein A by adding a promoter belongs to the technology field of the metabolism regulation optimized fermentation process. The method utilizes marine filamentous fungus Aspergillus glaucus HB1-19 of CCTCC M 206022 as a production strain, simvastatin, phthalic acid, citric acid or short-chain fatty acid, such as acetic acid, propionic acid, malonic acid are independently added in a fermentation culture medium as the promoter, or the promoters are mixedly added for promoting the synthesis efficiency for producing the viridogrisein A. The final yield can achieve 36.2mg / l which is 2.84 times of the original level. The method has important significance for researching the pharmacology and pharmacodynamics of the viridogrisein A.
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Description

technical field

[0001] The invention relates to a method for increasing the yield of griseovirmycin A, in particular to a method for increasing the yield of griseoviridin A by adding accelerators alone or in combination. It belongs to the technical field of metabolic regulation and optimization of fermentation process. Background technique

[0002] Giseoviridin A is a kind of independently isolated marine fungus Aspergillus glaucus (Aspergillus glaucus) HB1-19 (preservation date 2006.3.20, China Center for Type Culture Collection, preservation number CCTCCM 206022) by Ocean University of China. Anthrone lactone compound with intellectual property rights and brand-new structure with anticancer activity. Giseoviridin A uses 9-anthrone as the core, and C-10 and C-4 in the molecule form a six-membered lactone ring. As evaluated by the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, it has a strong inhibitory effect on the proliferation of human lung cancer A5...

Claims

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