DNA array analysis as a diagnostic for current and emerging strains of influenza

Abstract

Embodiments herein provide for methods, compositions and apparati for detection and/or diagnosis of virus types, subtypes and/or strains. In particular embodiments, the virus is an influenza virus. The apparatus may include a microarray with attached capture probes, designed to bind to oligonucleotides capable of binding at least a portion of a nucleic acid sequence of one or more target genes in a broad array of influenza types, subtypes or strains. The compositions may include isolated nucleic acids as capture probes, target sequences and/or tagged label probes, of use for diagnosis and/or detection of influenza virus.

Description

[0001] Pursuant to 35 U.S.C. §119(e), this application claims U.S. Provisional Patent Application Serial No. 60 / 759,670 filed January 18, 2006 and U.S. Provisional Patent Application Serial No. 60 / 784,751 filed March 21, 2006 Both of these two U.S. Provisional Patent Applications are hereby incorporated by reference in their entirety. technical field [0002] Embodiments herein relate to compositions, methods and devices for influenza virus detection and differential diagnosis. In some embodiments, influenza virus types A (A), B (B) and C (C) can be distinguished from each other. In certain embodiments, influenza A virus subtypes can be distinguished from each other. In a specific embodiment, various strains of influenza A virus can be distinguished from each other. technical background [0003] Influenza viruses are orthomyxoviruses with three types: A (A), B (B) and C (C). Each type can be distinguished by nucleoprotein antigenicity. Types A and B are the most clinical...

AI Technical Summary

Problems solved by technology

It is of great concern that the natural and engineered genetic changes experienced by influenza A viruses could lead to the emergence of viruses that can spread rapidly and lethally in populations

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