Streptomycete and application thereof in reduction of aromatic ketone

Abstract

The invention relates to the field of biocatalysis, and in particular relates to a streptomyces (Streptomyces sp.DUT003 with the preserving number of CGMCC2518) and application thereof in the reduction of rigid macrocyclic aromatic ketone such as substituted fluorenone. With the streptomyces, aromatic ketone, in particular the rigid macrocyclic aromatic ketone such as the substituted fluorenone can be reduced with high efficiency; products are aromatic alcohol and the aromatic alcohol with optical activity, the problems of synthesizing the aromatic alcohol and the aromatic alcohol with optical activity chemically and industrially are solved, the conversion rate can reach between 89 and 98 percent, the products have high stereoselectivity, and the ee value is between 83 and 100 percent. The streptomyces has the advantages of easy culture, mild reduction and reaction condition, simple operation steps, less environmental pollution, and good prospect of industrial application and development.

Description

A kind of streptomyces and its application in reducing aromatic ketones technical field The invention relates to the field of biocatalysis, in particular to a streptomycete and its application in reducing macrocyclic rigid aromatic ketones, such as substituted fluorenones. technical background Aromatic alcohols or optically active aromatic alcohols are important structural units of many pharmaceutical intermediates, catalysts, analytical reagents, food additives, and advanced photoconductive materials. At present, it is mainly obtained chemically through the reduction of aromatic ketones. However, its synthetic method has problems such as cumbersome steps, low yield, high cost, and serious environmental pollution in chemistry. The reason is that the rigid structure of aromatic ketones creates high steric hindrance, which prevents the access of the catalyst. Especially, the reduction or stereoselective reduction of some rigid macrocyclic aromatic ketones such as substitut...

AI Technical Summary

Problems solved by technology

The object of the present invention is to aim at the characteristics of aromatic ketones, especially rigid macrocyclic aromatic ketones, which are difficult to reduce, and the chemical method conditions are harsh, difficult to control, low yield and stereoselectivity, and environmental pollution. Aromatic ketone strains to solve the problems of chemical synthesis and industrial preparation of aromatic alcohols and optically active aromatic alcohols, and at the same time solve problems such as environmental pollution

Images