Gargle tablet composition and preparation method thereof

A mouthwash tablet and mixture technology, which is applied in the field of oral rapid disintegration mouthwash composition and preparation, can solve the problems of oral stimulation, harsh production conditions, high packaging cost, etc., and achieve long shelf life, good stability, The effect of low packaging cost

Inactive Publication Date: 2009-06-17
王惠明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there are also effervescent tablet dosage forms of mouthwash, but effervescent tablets require harsh production conditions, high packaging costs, and are limited in use because they contain acid-base pairs, which can cause irritation to the oral cavity.

Method used

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  • Gargle tablet composition and preparation method thereof
  • Gargle tablet composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Preparation of Sodium Fluoride-containing Mouthwash Tablets

[0058] Composition 1:

[0059] sodium fluoride 5mg Mannitol 378mg Povidone K30 4.5mg PROSOLV SMCC 50 75mg Crospovidone XL-10 25mg stevia 2.5mg Menthol 10mg total 500mg

[0060] Weigh sodium fluoride and mannitol respectively according to the prescription, mix well, add povidone K30 solution, stir, pass through a 40-mesh sieve to granulate, and dry. The above-mentioned granules are mixed with other raw and auxiliary materials, and the tablet is punched with a shallow arc of 13mm, and the hardness of the tablet is controlled at 4kgf. The disintegration time in the oral cavity is 20 seconds.

[0061] Composition 2:

[0062] sodium fluoride 5mg Xylitol 358mg hypromellose 4.5mg PROSOLV SMCC 50 75mg Crospovidone XL-10 25mg aspartame 2.5mg Refreshing alcohol 20mg Vanillin 10mg ...

Embodiment 2

[0067] Example 2 Preparation of Mouthwash Tablets Containing Sodium Fluoride and Cetylpyridinium Chloride

[0068] Composition 1:

[0069] sodium fluoride 5mg cetylpyridinium chloride 2mg

[0070] Mannitol 340mg Povidone K30 5.6mg PROSOLV SMCC 50 44mg Crospovidone XL-10 22mg stevia 2.2mg Menthol 17.5mg total 438.3 mg

[0071] Weigh sodium fluoride, cetylpyridinium chloride, and mannitol respectively according to the prescription, mix well, add povidone K30 solution, stir, pass through a 40-mesh sieve to granulate, and dry. Disperse other materials in PROSOLV SMCC 50 and mix with the above granules. The tablet is punched with a shallow arc of 13mm, and the hardness of the tablet is controlled at 4kgf. The disintegration time in the oral cavity is 20 seconds.

[0072] Composition 2:

[0073] sodium fluoride 5mg cetylpyridinium chloride 5mg Mannitol 385mg Povidon...

Embodiment 3

[0084] Example 3 Preparation of mouthwash tablets containing sodium fluoride, cetylpyridinium chloride and carbamide peroxide

[0085] Composition 1:

[0086] sodium fluoride 5mg cetylpyridinium chloride 5mg Carbamide peroxide 50mg Mannitol 380mg Povidone K30 5.7mg PROSOLV SMCC 50 100mg Crospovidone XL-10 25mg stevia 5mg Menthol 20mg Sodium stearate fumarate 5mg total 600.7mg

[0087] Weigh sodium fluoride, cetylpyridinium chloride, and mannitol respectively according to the prescription, mix well, add povidone K30 solution, stir, pass through a 40-mesh sieve to granulate, and dry. Disperse other materials in PROSOLV SMCC 50 and mix with the above granules. The tablet is punched with a shallow arc of 13mm, and the hardness of the tablet is controlled at 4kgf. The disintegration time in the oral cavity is 20 seconds.

[0088] Composition 2:

[0089] sodium fluoride 5mg c...

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Abstract

The present invention belongs to the field of oral cleaning health-caring object, and especially to a gargle tablet composition and a preparing method thereof. The present invention adopts a quick oral disintegrating technique to cause that a tablet with a certain size is disintegrated in oral cavity in scores of seconds. The active component is disintegrated quickly. The dissolved amount in 30 seconds can be higher than 75%. The functions of dental-cavity prevention and / or bacterium restriction and / or whitening are exerted. The efficacy of one tablet is same to the efficacy of 10-20ml of gargle water. The quick oral disintegrating gargle table related by the invention is a non-effervescence system rapid oral disintegrating tablet and has the advantages of no high requirement for producing condition and packaging material, and low cost. The producing condition and packaging material of common tablet can be adopted. The quick oral disintegrating gargle table related by the invention also has the advantages of easy carrying, simple using method and innovation to a novel oral cleaning health-caring concept. The quick oral disintegrating gargle table related by the invention satisfies the requirement of people in modern life, especially the office worker and the person who often go on errand or visit or in long-time outdoor action to the oral cleaning health-caring.

Description

technical field [0001] The invention belongs to the field of oral hygiene and health care products, and relates to a composition and a preparation method of an oral quick-disintegrating mouthwash tablet. Background technique [0002] Oral health is a mirror of human health. At present, most people's concept of oral care only stays in the understanding of "brushing teeth in the morning and evening". In fact, brushing can only remove 50% of dental plaque. "A comprehensive oral health regimen goes beyond brushing alone". A complete oral care regimen is essential for healthy teeth. For places that are hard to reach with a toothbrush, the mouthwash with antiseptic function can penetrate deeply and clean the mouth thoroughly. Targeted application of mouthwash can not only ensure a healthy oral environment, but also enhance one's public image and enhance self-confidence in social activities. Mouthwashes with certain functions are increasingly important in people's daily oral c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/20A61K8/22A61K8/24A61K8/38A61K8/49A61Q11/00
CPCA61K9/0063A61Q17/005A61K8/731A61K8/22A61K8/38A61K9/0095A61K8/4926A61Q11/00A61K8/20A61K9/0056A61K8/0216A61K8/347
Inventor 王惠明
Owner 王惠明
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