Preparation and application of ceftibuten dry suspension agent
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A technology of dry suspension and ceftibuten, which is applied in the new field of medicine, can solve problems such as inconvenience, and achieve the effects of high quality, simple method and good stability
Inactive Publication Date: 2009-07-01
BEIJING HOPE HUGE PHARM SCI
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[0039] Pass cefbutene, sucrose, mannitol, and sodium chloride through an 80-mesh sieve respectively, weigh them according to the recipe, mix them evenly, add 50% ethanol to make soft material, granulate, dry at 60°C (moisture <1.0%), and then make the whole product. granules, and then add the adjuvant carbomer, strawberry essence, aspartame, mix evenly, and divide the intermediate after passing various quality inspections.
Embodiment 2
[0040] Example 2: Specification 10000 bags
[0041] prescription:
[0042] Ceftibuten 2000g 4000g
[0043] Cane sugar 18000g 18000g
[0044] Mannitol 2500g 2500g
[0045] Sodium Chloride 100g 100g
[0046] Carbomer 16g 16g
[0047] Aspartame 10g 20g
[0048] Strawberry Flavor 4g 4g
[0049] 50% ethanol appropriate amount
[0050] Method:
[0051] Pass cefbutene, sucrose, mannitol, and sodium chloride through an 80-mesh sieve respectively, weigh them according to the recipe, mix them evenly, add 50% ethanol to make soft material, granulate, dry at 60°C (moisture <1.0%), and then make the whole product. granules, then add the adjuvant carbomer, strawberry essence, aspartame, mix evenly, and divide the intermediate after passing various quality inspections.
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Abstract
The invention belongs to the novel technology field of the medicines and relates to a preparation and use of a ceftibuten dry suspension. The ceftibuten dry suspension is characterized by comprising, but not being limited by following excipients available by pharmacy: sucrose, mannitol, etc. as the loading agent; sodium chloride, aspartame, strawberry essence, etc. as the flavoring agent; carbomer, sodium carboxymethyl cellulose, sodium carboxy nethyl, etc. as the suspending agent. The ceftibuten dry suspension is used for treating: upper respiratory tract infection such as pharyngitis, antiaditis, scarlet fever, paranasal sinusitis, and otitis medium; lower respiratory tract infection such as acute bronchitis, acute attack of chronic bronchitis and pneumonia; urinary tract infection; enteritis and gastroenteritis.
Description
technical field [0001] The invention belongs to the field of new pharmaceutical technology, and relates to a new dosage form of cefbutene, which is used for treating upper respiratory tract infections such as pharyngitis, tonsillitis, scarlet fever, paranasal sinusitis and otitis media; lower respiratory tract infections such as acute bronchitis, acute bronchitis and chronic bronchitis Attack, pneumonia; urinary tract infection; enteritis and gastroenteritis. Specifically, the preparation and application of a ceftibuten dry suspension. Background technique [0002] Cephalosporin antibiotics have the characteristics of broad antibacterial spectrum, strong antibacterial activity, high efficacy and low toxicity. Since the first-generation cephalosporin cefotaxime was successfully developed in China in the 1970s, cephalosporin antibiotics have developed rapidly in my country. In 2001, the national sales of cephalosporin antibiotics reached 16 billion yuan, and the annual rate o...
Claims
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Application Information
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