Mitotic progression genes and methods of modulating mitosis
A compound and biologically active technology, applied in the field of mitosis process genes and regulation of mitosis, can solve problems such as adverse side effects
Inactive Publication Date: 2009-08-26
PRESIDENT & FELLOWS OF HARVARD COLLEGE +1
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[0001] Taxotere and some other important anti-mitotic cancer drugs target tubulin, but since tubulin is contained not only in dividing cells but also in non-dividing cells, such drugs have many adverse side effects
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[0158] Descriptions of specific embodiments of the invention are presented for purposes of illustration. It is not intended to be exhaustive or to limit the scope of the invention to the specific forms described herein. While the invention has been described in terms of several embodiments, it will be understood by those skilled in the art that various modifications may be made without departing from the spirit and scope of the invention as set forth in the claims. All patents, patent applications, and publications cited herein are hereby incorporated by reference.
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Abstract
The invention features methods of identifying candidate therapeutic compounds for the treatment of proliferative disorder. The invention also features methods for treating a proliferative disorder.
Description
Background of the invention [0001] Taxotere and some other important anti-mitotic cancer drugs target tubulin, but since tubulin is contained not only in dividing cells but also in non-dividing cells, such drugs have many Undesirable side effects. Specificity can be increased by targeting only those proteins that are required during mitosis and do not function in non-dividing cellular processes. Cell-based phenotypic screens at Harvard Medical School identified for the first time small antimitotic molecules (monostrins) that do not target tubulin but act by inhibiting the mitotic kinesin Eg5. Other small molecule inhibitors of Eg5 are currently in clinical trials for cancer therapy. [0002] High-throughput siRNA screens provide an alternative approach for the rapid identification of new therapeutic targets that, if inactivated, affect cellular processes of interest. Since taxanes and other microtubule inhibitors activate spindle checkpoints, identification of new component...
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IPC IPC(8): C12P19/34C12N5/00A01N43/04A61K31/70
CPCC12Y207/11001C12N9/1205G01N33/5011C12Y301/02015C12Q1/485C12Q1/37A61P35/00A61P43/00C12Q1/025C12Q1/6837C12Q1/6876C12Q2600/136G01N33/57407
Inventor R·W·金S·利曼E·钟S·纳特桑C·B·埃普斯泰恩
Owner PRESIDENT & FELLOWS OF HARVARD COLLEGE