Method for extracting flavonoid compound from bracken

A technology of Pteris flavonoids and extraction methods, which is applied in the fields of medical raw materials derived from ferns/filamentous plants, digestive system, organic chemistry, etc., and can solve the problems of loss of flavonoid aglycon components and large waste of medicinal material resources, etc.

Active Publication Date: 2009-09-16
BEIJING SUNHO PHARMA
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  • Application Information

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Problems solved by technology

The Chinese patent application with the authorized notification number CN100355428C discloses a method for preparing flavonol glycosides from Pteris vulgaris and its application in medicines for inflammatory diseases. Enrichment, but the loss of flavonoid aglycon components that also have antibacterial effects, a large waste of medicinal resources

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  • Method for extracting flavonoid compound from bracken

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Embodiment 1

[0010] 1000g of dried medicinal materials of Pteris vulgaris, crushed into coarse powder, add 10 times the amount of 60% ethanol to reflux extraction for 3 times, each time for 1.5 hours, filter, combine the filtrate, concentrate the filtrate under reduced pressure to form an extract, use 3 times the amount of the extract The water dispersion of petroleum ether is used to extract the dispersion liquid, and the amount of petroleum ether is 1-1.5 times of the volume of the dispersion liquid each time. When the color of the petroleum ether layer becomes lighter, the residual petroleum ether in the dispersion liquid is evaporated under reduced pressure, and then 1: 1 water-saturated ethyl acetate-n-butanol mixed solvent system to extract the dispersion, until the color of the upper layer extract becomes lighter, combine the ethyl acetate-n-butanol mixed solvent system extract, and concentrate under reduced pressure to form an extract. Organic solvent, add 0.3% NaOH solution of 20 t...

Embodiment 2

[0014] 1000g of dried medicinal materials of Pteris vulgaris, crushed into coarse powder, add 10 times the amount of 40% ethanol to reflux extraction for 3 times, each time for 1.5 hours, filter, combine the filtrate, concentrate the filtrate under reduced pressure to form an extract, use 3 times the amount of the extract disperse in water, use petroleum ether to extract the dispersion liquid, the amount of petroleum ether is 1-1.5 times the volume of the dispersion liquid each time, until the color of the petroleum ether layer becomes lighter, evaporate the residual petroleum ether in the dispersion liquid under reduced pressure, and then water-saturated Extract the dispersion liquid with ethyl acetate solvent until the color of the upper layer extract becomes light, combine the ethyl acetate solvent extract, concentrate under reduced pressure to form an extract, without the smell of ethyl acetate, add 0.15 % NaOH solution, stirring to dissolve, standing for 24 hours, filterin...

Embodiment 3

[0016] 1000g of dried Pteris vulgaris, crushed into coarse powder, add 10 times the amount of 70% ethanol to reflux extraction for 3 times, each time for 1.5 hours, filter, combine the filtrate, concentrate the filtrate under reduced pressure to form an extract, use 3 times the amount of the extract disperse in water, use petroleum ether to extract the dispersion liquid, the amount of petroleum ether is 1-1.5 times the volume of the dispersion liquid each time, until the color of the petroleum ether layer becomes lighter, evaporate the residual petroleum ether in the dispersion liquid under reduced pressure, and then water-saturated Extract the dispersion liquid with n-butanol solvent until the color of the upper layer extract becomes lighter, combine the n-butanol solvent extract, concentrate under reduced pressure to form an extract, without n-butanol smell, add 0.60 % NaOH solution, stirring to dissolve, standing for 24 hours, filtering, taking the filtrate, adjusting the pH...

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Abstract

The invention relates to a method for extracting flavonoid compound from bracken crude drug. After the bracken crude drug is extracted by ethanol and degreased by ligarine, ethyl acetate-normal butanol mixed solvent system is used for extracting and enriching flavonoid compound, and the flavonoid compound is prepared by the alkali dissolution and acid precipitation of the obtained extract paste. The method is convenient and easy for operation and suitable for industrialized preparation and has little energy consumption. In addition, the extract flavonoid compound has high purity which can reach more than 60 percent.

Description

technical field [0001] The invention belongs to the field of preparation of active ingredients of traditional Chinese medicines, and in particular relates to a method for extracting flavonoids from Pteris flavonoids. Background technique [0002] Pteris multifida Poir. is the dry whole herb of the fern family Pteris multifida Poir. It grows on walls, wells and limestone crevices or under bushes, and is distributed all over the country. Pteris vulgaris is cold and bitter in taste, enters the large intestine, kidney, stomach and liver meridians, has the effects of clearing away heat and dampness, reducing swelling and detoxification, cooling blood and stopping bleeding, and is mainly used for gonorrhea, dysentery, enteritis, hepatitis, pharyngitis, urinary tract inflammation, tonsils Rheumatism and other diseases. [0003] Ferntail grass contains a variety of active ingredients, including flavonoids, terpenoids, sterols, phenylpropanoids, and volatile oils, among which flavo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61P1/00A61P11/04A61P13/00A61P29/00C07D311/30
Inventor 张树祥熊国裕
Owner BEIJING SUNHO PHARMA
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