Common lamiophlomis root chewable tablet and preparation thereof

A unique and chewable tablet technology, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of slow onset of action and small disintegration, and achieve the effect of definite curative effect and low price

Active Publication Date: 2009-10-28
KANGYA OF NINGXIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] However, capsules generally have a sense of fear for those patients who are inconvenient to swallow, such as the elderly and children, and the degree of disintegration is small, and the onset of action is slow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Unique Flavor 1000g

[0039] Mannitol 100g

[0040] Starch 220g

[0041] Sucrose 380g

[0042] Sodium saccharin 6g

[0043] Magnesium stearate 8g

[0044] Appropriate amount of starch slurry (5%)

[0045]

[0046] Makes 1000 pieces

[0047] (1) Take 1000g of Duyiwei, grind it, add water and decoct three times (10, 8, 6 times the water volume), each time for 1 hour, combine the decoction, filter, and concentrate the filtrate into a clear paste with a relative density of 1.3, at 75°C Spray-dried, pulverized, and passed through a 100-mesh sieve for later use.

[0048] (2) Grind mannitol, starch, sucrose and sodium saccharin respectively, and pass through a 100-mesh sieve for later use.

[0049] (3) Take the prescribed amount of sodium saccharin, mix it with the prescribed amount of starch in an equal amount, and then add the prescribed amount of Duyiwei extract powder, mannitol and sucrose in turn and mix evenly; use 5% starch slurry to pr...

Embodiment 2

[0051] Unique Flavor 800g

[0052] Mannitol 350g

[0053] Sucrose 380g

[0054] Aspartame 5g

[0055] Magnesium stearate 8g

[0056] Appropriate amount of starch slurry (5%)

[0057]

[0058] Makes 1000 pieces

[0059] (1) Take 800g of Duyiwei, grind it, add water to decoct three times (10, 8, 6 times the water volume), each time for 1 hour, combine the decoction, filter, and concentrate the filtrate into a clear paste with a relative density of 1.3. Spray-dried, pulverized, and passed through a 100-mesh sieve for later use.

[0060] (2) Grinding the mannitol, sucrose and aspartame respectively, passing through a 100-mesh sieve for later use.

[0061] (3) Get the aspartame of the prescription quantity, adopt the method of increasing in equal amounts to mix evenly with the mannitol of the prescription quantity, then add the Duyiwei extract powder of the prescription quantity and mix uniformly with sucrose; use 5% starch slurry Make soft materia...

Embodiment 3

[0063] Unique Flavor 1200g

[0064] Microcrystalline Cellulose 100g

[0065] Lactose 200g

[0066] Sucrose 300g

[0067] Aspartame 5g

[0068] Disodium Glycyrrhizinate 20g

[0069] Magnesium stearate 8g

[0070] Appropriate amount of starch slurry (5%)

[0071]

[0072] Makes 1000 pieces

[0073] (1) Take 1200g of Duyiwei, grind it, add water to decoct three times (10, 8, 6 times the water volume), each time for 1 hour, combine the decoction, filter, and concentrate the filtrate into a clear paste with a relative density of 1.3. Spray-dried, pulverized, and passed through a 100-mesh sieve for later use.

[0074] (2) Separately pulverize microcrystalline cellulose, lactose, sucrose, aspartame and disodium glycyrrhizinate, pass through a 100-mesh sieve for later use.

[0075] (3) Mix evenly the aspartame and disodium glycyrrhizinate of the prescribed amount, then add the Duyiwei extract powder, lactose, microcrystalline cellulose, and sucrose...

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PUM

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Abstract

The invention relates to a common lamiophlomis root chewable tablet and preparation thereof. The chewable tablet is a novel dosage form of common lamiophlomis root prepared from a common lamiophlomis root, a filler, a corrigent, a lubricant, and a binder. It is proposed that the medicament is made into chewable tablets with consideration on inconvenience in taking the medicament by patient and fear of medicament admission of the aged and the children. Comparing with the ordinary tablets and capsules, the chewable tablet can be chewed and swallowed, having great disintegrating degree. The chewable tablet is not only beneficial to absorption of effective ingredients, shortening affecting time, but also better in mouth feeling comparing with ordinary tablet and capsule, making the aged and the children eager to take, thus adaptability of patient in taking the medicament is enhanced. And the chewable tablet is suitable for large scale production because of no special requirement for the apparatus.

Description

technical field [0001] The invention belongs to the technical field of medicine and pharmacy, and in particular relates to a unique chewable tablet and a preparation method thereof. Background technique [0002] Duyiwei is the dry root, stem or whole herb of Lamiophlomis rotate (Benth.) Kudo, a plant of the genus Lamiophlomis in the family Lamiaceae. It is distributed in Qinghai, Tibet, Sichuan, Gansu and other Tibetan areas of China, and often grows at altitudes of 3900-5100 meters. Alpine gravel beaches, river beaches or stony meadows are common folk medicines of Tibetan, Mongolian, Naxi and other ethnic groups. As early as the Tang Dynasty, it has been recorded in the famous Tibetan medical works "Four Medical Codes" and "Yuewang Medicine Diagnosis". Tibetan medicine uses it for the treatment of osteomyelitis, joint jaundice, fractures, bruises, gunshot wounds and other diseases. [0003] Studies have shown that Duyiwei has a wide range of pharmacological activities: ...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/20A61P7/04A61P29/00A61K125/00
Inventor 杨亚军刘向红
Owner KANGYA OF NINGXIA PHARMA
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