Sensor

一种感测装置、测定部的技术,应用在利用物质吸收称量等方向,能够解决无法充分发挥优点等问题,达到抑制振荡频率的变动、抑制自发热的效果

Inactive Publication Date: 2009-10-28
NIHON DEMPA KOGYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Therefore, there is a problem that even if the frequency is detected by a high-precision method intentionally, its advantages cannot be fully utilized.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Various changes were made to the drive current to conduct experiments to obtain the frequency-temperature characteristics of the crystal resonator 24 , and the case where the drive current was 10 mA among the data was studied. Figure 9 Indicates the difference between the frequency-temperature characteristics at a driving current of 10 mA and the frequency-temperature characteristics at a driving current of 0.1 mA as a reference. Figure 10 The frequency-temperature characteristics when the drive current is 0.1 mA and the frequency-temperature characteristics when the drive current is 10 mA are shown. Such as Figure 10 As shown, when setting the frequency at 0.1mA driving current at 85°C as f1, according to Figure 9 It can be seen that the frequency at 10mA driving current at 85°C is f1+0.7×10 -6 . The f1+0.7×10 -6 When the driving current is 0.1 mA, the frequency of is detected at a temperature of (85+Δt)°C, whereas when the driving current is 10 mA, it is detec...

Embodiment 1-1

[0054] In the measurement of the sensing object using the above-mentioned sensing device, a predetermined amount of pure water was supplied into the quartz sensor 1, and an oscillation driving power was applied so that the driving current of the quartz plate 20 was 0.2 mA. Next, with a driving current of 0.2 mA applied to the quartz plate 20 , a predetermined amount of a PBS solution (phosphate buffer) containing 100 μg / ml of CRP antibody was injected into the pure water in the quartz sensor 1 . Then, the state of the oscillation frequency of the quartz vibrator 24 before and after the antigen-antibody reaction was observed. its status as Figure 11 shown. In addition, a quartz vibrator 24 with an oscillation frequency of 9.176 MHz was used in this measurement.

Embodiment 2-1

[0058] Except that a predetermined amount of PBS solution containing 10 μg / ml of the CRP antibody was injected into the pure water in the quartz sensor 1, the amount of supply of pure water and the driving current were the same as those in Example 1-1. Determination. Then, the state of the oscillation frequency of the quartz vibrator 24 before and after the antigen-antibody reaction was observed. its status as Figure 12 shown.

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Abstract

It is an object of the present invention to provide a sensing instrument using a piezoelectric resonator such as a quartz resonator which changes in natural frequency when coming into contact with a liquid to adsorb a substance to be sensed in the liquid, the sensing instrument having a reduced adverse effect accompanying improvement in detection sensitivity precision of a frequency change. The sensing instrument of the present invention includes: an oscillator circuit supplying a piezoelectric resonator with oscillation driving power for oscillating the piezoelectric resonator so as to set a driving current to 0.3 mA or less; and a measuring unit measuring a concentration of the substance to be sensed based on an oscillation output of the oscillator circuit. This structure can suppress self-heating of the piezoelectric resonator. Consequently, a change of the oscillation frequency of the piezoelectric oscillator is suppressed, which as a result enables accurate detection of a variation of the frequency due to the adsorption of the substance to be sensed.

Description

technical field [0001] The present invention relates to a sensing device for sensing a sensing object in a liquid by detecting a change in the natural frequency of the piezoelectric vibrator, such as a quartz vibrator. The adsorption layer of the sensing object is in contact with the liquid, and its natural oscillation frequency changes due to the adsorption of the sensing object in the liquid. Background technique [0002] As a method of sensing trace substances, a sensing device using a quartz vibrator is known. In this sensing device, a quartz sensor is formed by forming an adsorption layer for absorbing the sensing object on the surface of the quartz vibrator. When the sensing object is adsorbed on the quartz vibrator, specifically, on the adsorption layer, its inherent The oscillation frequency changes according to the adsorption amount, and the presence or absence or the concentration of the sensing object is determined by using this point. This sensing device has a w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N5/02
CPCG01N5/02
Inventor 小山光明
Owner NIHON DEMPA KOGYO CO LTD
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