Formulations of phospholipase enzyme inhibitors

A technology of active agent and solubilizer, applied in anti-inflammatory agents, non-central analgesics, non-active ingredients of oil/fat/wax, etc., can solve problems such as unpurified proteins
CN101573111AInactive Publication Date: 2009-11-04WYETH LLC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WYETH LLC
Publication Date
2009-11-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention refers to formulations of inhibitors of phospholipase enzymes, such as cytosolic PLA2, compositions containing the same and processes for manufacture thereof.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of US Provisional Patent Application No. 60 / 855,569, filed October 31, 2006, which is incorporated herein by reference in its entirety. field of invention

[0003] The present invention relates to phospholipases (e.g. cytosolic PLA 2 ) inhibitor formulations, compositions containing the same and methods for their preparation. Background of the invention

[0004] Leukotrienes and prostaglandins are important mediators of inflammation, and they participate in the establishment of inflammatory responses in different ways. Leukotrienes recruit inflammatory cells such as neutrophils to sites of inflammation, facilitate extravasation of these cells and stimulate the release of tissue-damaging superoxide and proteases. Leukotrienes also play a pathophysiological role in asthma-induced hypersensitivity [see, eg, B. Samuelson et al., Science, 237:1171-76 (1987)]. Prostaglandins enhance th...

Claims

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