Breast perfusion preparation for treating mammitis of milk cow in lactation period and preparation method thereof

Abstract

The invention provides a breast perfusion preparation for treating mammitis of milk cow in lactation period, which belongs to the field of medical preparation for veterinary use; every 3g of the perfusion preparation contains 150-250 mg of amoxicillin, 50-125 mg of sulbactam, 5-15 mg of prednisolone and the rest of substrate; the substrate contains 0.1-12% of suspending aid, 0.1-2% of wetting agent, 0.01-1% of antioxidant, 0.05-1% of preservative and the rest of dispersion medium; the invention can be obtained via the following steps: firstly, dissolving or dispersing suspending aid, antioxidant, wetting agent and preservative into proper amount of dispersion medium, then slowly adding the rest of the dispersion medium into a colloid mill to obtain the substrate, adding medicine into the substrate, grinding via the alternating method of circularly grinding and non-circularly grinding. The preparation of the invention is simple in preparation technique, easy to realize industrialization, low in production cost, low in expenditure for treatment, low in toxicity, wide to use and high in efficiency; the invention can be clinically used for treating mammitis in lactation period caused by Gram positive bacterium and Gram negative bacterium.

Description

technical field [0001] The invention relates to veterinary medicine, in particular to a udder perfusion agent for treating mastitis of lactating cows. Background technique [0002] Cow mastitis is a common disease. About 50% of the world's dairy cows suffer from various types of mastitis. Mastitis is one of the most expensive diseases of dairy cows, and the treatment of sick cows is very expensive. Udder health problems are a major cause of cow culling. For example, the culling rates of dairy cows in Finland, Norway, and Sweden due to udder health problems are 35%, 19%, and 22%, respectively. The direct economic loss caused by cow mastitis in the United States reaches 2 billion U.S. dollars every year. The annual loss caused by recessive mastitis in our country is about 135 million yuan. [0003] Cow mastitis is divided into clinical mastitis and recessive mastitis. The pathogens are diverse, such as bacteria, mycoplasma, fungi, viruses, etc. can cause mastitis. Among ...

AI Technical Summary

Problems solved by technology

Among them, the compound amoxicillin breast injection with amoxicillin, clavulanic acid, and prednisolone as the main ingredients developed by Pfizer in the United States has a better clinical effect in veterinary medicine, but the drug still contains clavula Acid is expensive, unstable, easy to decompose and other defects

Images