Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hyperbranched polymer and preparation method and application thereof

A technology of hyperbranched polymers and hyperbranched polyurethanes, applied in the field of nanomaterials, can solve problems such as narrow molecular weight distribution of hyperbranched polyurethanes, inability to use as drug carriers, and inability to form micelles, etc., to improve bioavailability and biological activity, Wide applicability, improving the effect of drug loading

Inactive Publication Date: 2010-01-20
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

GPC measurement shows that the molecular weight distribution of the synthesized hyperbranched polyurethane is narrow and has monodispersity; the viscosity is lower than that of linear molecules with the

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hyperbranched polymer and preparation method and application thereof
  • Hyperbranched polymer and preparation method and application thereof
  • Hyperbranched polymer and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1. Preparation of hyperbranched polyurethane

[0046] A. Preparation of N, N-dihydroxyethyl-3-aminomethyl acrylate monomer

[0047] Add 8.609g methyl acrylate, 10.514g diethanolamine and 10ml methanol mixture in the there-necked flask, at room temperature and logical N 2 Stir for 30 minutes under normal conditions, then heat up to 40 ° C for 4 hours, and then remove excess methyl acrylate and methanol through vacuum distillation to obtain a colorless and transparent oily liquid, namely, N, N-dihydroxyethyl-3-amino Methyl acrylate monomer.

[0048] B. Preparation of the second generation hyperbranched polyurethane polymer

[0049] Add 1.342g 1,1,1-trimethylolpropane, 5.93g N,N-dihydroxyethyl-3-aminomethyl acrylate monomer and 0.017g tetraisobutoxytitanium in the there-necked flask as catalyst , the reaction system at N 2 Under protection, the reaction was carried out at a constant temperature of 120°C for 12 hours to obtain a yellow viscous liquid. Dissolve the crud...

Embodiment 2

[0058] 1. Preparation of hyperbranched polyurethane

[0059] A. Preparation of N, N-dihydroxyethyl-3-aminomethyl acrylate monomer

[0060] In the there-necked flask, add 8.609g methyl acrylate, 10.514g diethanolamine and 10ml methanol, the mixture is at room temperature and logical N 2 Under normal circumstances, stir for 30 minutes, then heat up to 40 ° C for 4 hours, and then remove excess methyl acrylate and methanol through vacuum distillation to obtain a colorless and transparent oily liquid N, N-dihydroxyethyl-3-aminomethacrylate ester monomer.

[0061] B. Preparation of the second generation hyperbranched polyurethane

[0062] Add 1.342g 1,1,1-trimethylolpropane, 15.93g N,N-dihydroxyethyl-3-aminomethyl acrylate monomer and 0.017g tetraisobutoxytitanium in the three-necked flask as catalyst , the reaction system at N 2 Under protection, the reaction was carried out at a constant temperature of 120°C for 12 hours to obtain a yellow viscous liquid. Dissolve the crude ...

Embodiment 3

[0068] 1. Preparation of hyperbranched polyurethane

[0069] A. Preparation of N, N-dihydroxyethyl-3-aminomethyl acrylate monomer

[0070] Add 8.609g methyl acrylate, 10.514g diethanolamine and 10ml methanol mixture in the there-necked flask, at room temperature and logical N 2 Under normal circumstances, stir for 30 minutes, then raise the temperature to 40 ° C for 4 hours, and then remove excess methyl acrylate and methanol through vacuum distillation to obtain a colorless and transparent oily liquid N, N-dihydroxyethyl-3-aminoacrylic acid Methyl ester monomer.

[0071] B. Preparation of the second generation hyperbranched polyurethane polymer

[0072] Add 1.342g 1,1,1-trimethylolpropane, 15.93g N,N-dihydroxyethyl-3-aminomethyl acrylate monomer and 0.017g tetraisobutoxytitanium in the three-necked flask as catalyst , should be system in N 2 Under protection, the reaction was carried out at a constant temperature of 120°C for 12 hours to obtain a yellow viscous liquid. D...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Critical micelle concentrationaaaaaaaaaa
Login to View More

Abstract

The invention provides a hyperbranched polymer and a preparation method and application thereof. The polymer has a structure shown as the following formula (I), wherein n is a positive integer from 1 to 5; B is aliphatic polyester; and the molecular weight of the polymer is between 4,000 kDa and 7,000 kDa. The invention also provides the method for preparing the polymer and a micelle formed by the polymer and a method for preparing the micelle. The micelle prepared by the polymer can be used for a medicament carrier material and has good biocompatibility; as the critical micelle concentration CMC is quite low and the formed micelle is stable and has small particle diameter and long circulation, the polymer micelle can be used for coating various hydrophilic and hydrophobic medicaments and is a medicament carrier with development prospect.

Description

technical field [0001] The invention relates to a hyperbranched polymer, a preparation method thereof, a micelle formed by the polymer, a preparation method and an application of the micelle. Specifically, the invention relates to a hyperbranched polyurethane-aliphatic polyester capable of forming micelles, which belongs to the technical field of nanomaterials. Background technique [0002] Dendritic macromolecules are a kind of dendritic macromolecules with high regularity and three-dimensional structure. Drugs and targeting groups, by modifying the surface of different polymers with different functional groups, can make the surface hydrophilic and increase biocompatibility. Through the construction reaction, a huge hydrophobic space can be formed inside the dendrimer. Due to the hydrophilic surface structure of dendrimers, the internal cavity and binding points can carry drugs, so this provides unique conditions for dendrimers as drug carriers, which can realize the true...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08G63/685C08G73/02C08G63/91C08J3/03A61K47/34
Inventor 吴雁蒋明
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com