In situ forming eye gel preparation for treating myopia and asthenopia and preparation method thereof

A technology for gel preparation and eye fatigue, which is applied in the field of ophthalmic ready-to-use gel preparation and its preparation with Zijinlong total alkaloids as the main drug, which can solve strong irritation, low bioavailability, and short residence time of drug ingredients And other issues

Inactive Publication Date: 2010-01-27
张达
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] In order to overcome the disadvantages of strong irritation, short residence time and low bioavailability of the drug ingredients in the actual use of the existing eye drops made of Zijinlong extract, the present i

Method used

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  • In situ forming eye gel preparation for treating myopia and asthenopia and preparation method thereof
  • In situ forming eye gel preparation for treating myopia and asthenopia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0041] The preparation method of the present invention includes the following schemes:

[0042] ①Take the crude powder of Zijinlong medicinal material, use 50%-100% ethanol as solvent, immerse for 24 hours and then carry out percolation or reflux extraction. The ethanol solution is concentrated under reduced pressure to a thick paste and refined with chloroform-ethanol to obtain Zijinlong total alkaloids ;

[0043] ②Take pH adjuster, bacteriostatic agent, stabilizer, osmotic pressure adjuster and viscosity increasing agent and the above extract, add appropriate amount of water for injection, stir to completely dissolve;

[0044] ③Take poloxamer and add it to the above solution, stir to make the dispersion uniform, and place in a cold place to make a transparent solution;

[0045] ④ Add water for injection to 1000ml, and filter aseptically.

Example Embodiment

[0047] Example 1

[0048] Preparation: 200g of Zijinlong extract, 407180g of poloxamer, and water for injection to 1000ml.

[0049] Preparation:

[0050] ①Take the crude powder of Zijinlong medicinal material, use 50%-100% ethanol as solvent, immerse for 24 hours and then carry out percolation or reflux extraction. The ethanol solution is concentrated under reduced pressure to a thick paste and refined with chloroform-ethanol to obtain Zijinlong total alkaloids ;

[0051] ②Take sodium chloride and the above extract, add appropriate amount of water for injection, and stir to dissolve completely;

[0052] ③Take poloxamer in the above solution, stir to make the dispersion uniform, and place in a cold place to make a transparent solution;

[0053] ④ Add water for injection to 1000ml, filter aseptically, and get it.

Example Embodiment

[0054] Example 2

[0055] Preparation: 500g of Zijinlong extract, 180g of Poloxamer 407, and water for injection to 1000ml.

[0056] Preparation method: Refer to Example 1.

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Abstract

The invention relates to an in situ forming eye gel preparation for treating myopia and asthenopia. The preparation takes total alkaloid from dactylicapnos scandens hutch as an effective active ingredient and also contains auxiliary material acceptable in pharmacy and water; the preparation also contains poloxamer serving as matrix which causes solution to generate phase change; taking 1000 parts of in situ forming eye gel by weight, 200-800 parts of dactylicapnos scandens hutch medical drug by weight, 50-300 parts of poloxamer by weight and 900-1100 parts of water by weight are prepared into solution whose pH value is 4.0-6.0. The preparation of the invention has accurate preparation ration, small irritation, long retention time in eyes and high bioavailability.

Description

technical field [0001] The invention relates to an ophthalmic preparation for treating juvenile myopia, pseudomyopia and eye fatigue caused by continuous short-distance use of eyesight, in particular to an ophthalmic instant gel preparation with total alkaloids as the main drug and its Preparation. Background technique [0002] 1. Technical background of in Situ Forming Eye Gel formulations [0003] In-situ gel (in-situ-gel), also known as in-situ gel, refers to the polymer material that responds to external stimuli at the site of administration after it is administered in a solution or semi-solid state, and undergoes a reversible dispersion state or conformation. Transformation to form semi-solid or liquid formulations. In recent years, with the rapid development of some "smart" polymers, especially some environment-sensitive polymer materials, the emergence and further development of in-situ gels, a new type of drug delivery system, have been promoted. Compared with tra...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/00A61K47/34A61P27/02A61P27/10
Inventor 张娜
Owner 张达
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