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In situ forming eye gel preparation for treating myopia and asthenopia and preparation method thereof

A technology for gel preparation and eye fatigue, which is applied in the field of ophthalmic ready-to-use gel preparation and its preparation with Zijinlong total alkaloids as the main drug, which can solve strong irritation, low bioavailability, and short residence time of drug ingredients And other issues

Inactive Publication Date: 2010-01-27
张达
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0021] In order to overcome the disadvantages of strong irritation, short residence time and low bioavailability of the drug ingredients in the actual use of the existing eye drops made of Zijinlong extract, the present invention aims to provide a quantitative and accurate New ophthalmic dosage form for treating eye fatigue and myopia with low irritation, long residence time in eyes and high bioavailability and preparation method thereof

Method used

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  • In situ forming eye gel preparation for treating myopia and asthenopia and preparation method thereof
  • In situ forming eye gel preparation for treating myopia and asthenopia and preparation method thereof

Examples

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preparation example Construction

[0041] The preparation method of the present invention comprises the following schemes:

[0042] ①Take the coarse powder of Zijinlong medicinal material, use 50%-100% ethanol as solvent, soak for 24 hours, carry out percolation or reflux extraction, concentrate the ethanol solution under reduced pressure to a thick paste, and refine it with chloroform-ethanol to obtain the total alkaloids of Zijinlong ;

[0043] ② Take the pH regulator, bacteriostatic agent, stabilizer, osmotic pressure regulator, thickener and the above extract, add an appropriate amount of water for injection, and stir to dissolve completely;

[0044] ③ Add poloxamer to the above solution, stir to disperse evenly, and place in a cold place to make a transparent solution;

[0045] ④ Add water for injection to 1000ml, filter it sterile.

Embodiment 1

[0048] Preparation: Zijinlong extract 200g, poloxamer 407180g, add water for injection to 1000ml.

[0049] Preparation:

[0050] ①Take the coarse powder of Zijinlong medicinal material, use 50%-100% ethanol as solvent, soak for 24 hours, carry out percolation or reflux extraction, concentrate the ethanol solution under reduced pressure to a thick paste, and refine it with chloroform-ethanol to obtain the total alkaloids of Zijinlong ;

[0051] ②Take sodium chloride and the above extract, add appropriate amount of water for injection, and stir to dissolve completely;

[0052] ③Take poloxamer in the above solution, stir to disperse evenly, and place in a cold place to make a transparent solution;

[0053] ④ Add water for injection to 1000ml, sterile filter, that is.

Embodiment 2

[0055] Preparation: Zijinlong 500g extract, Poloxamer 407 180g, add water for injection to 1000ml.

[0056] Preparation method: with reference to Example 1.

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Abstract

The invention relates to an in situ forming eye gel preparation for treating myopia and asthenopia. The preparation takes total alkaloid from dactylicapnos scandens hutch as an effective active ingredient and also contains auxiliary material acceptable in pharmacy and water; the preparation also contains poloxamer serving as matrix which causes solution to generate phase change; taking 1000 parts of in situ forming eye gel by weight, 200-800 parts of dactylicapnos scandens hutch medical drug by weight, 50-300 parts of poloxamer by weight and 900-1100 parts of water by weight are prepared into solution whose pH value is 4.0-6.0. The preparation of the invention has accurate preparation ration, small irritation, long retention time in eyes and high bioavailability.

Description

technical field [0001] The invention relates to an ophthalmic preparation for treating juvenile myopia, pseudomyopia and eye fatigue caused by continuous short-distance use of eyesight, in particular to an ophthalmic instant gel preparation with total alkaloids as the main drug and its Preparation. Background technique [0002] 1. Technical background of in Situ Forming Eye Gel formulations [0003] In-situ gel (in-situ-gel), also known as in-situ gel, refers to the polymer material that responds to external stimuli at the site of administration after it is administered in a solution or semi-solid state, and undergoes a reversible dispersion state or conformation. Transformation to form semi-solid or liquid formulations. In recent years, with the rapid development of some "smart" polymers, especially some environment-sensitive polymer materials, the emergence and further development of in-situ gels, a new type of drug delivery system, have been promoted. Compared with tra...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/00A61K47/34A61P27/02A61P27/10
Inventor 张娜
Owner 张达
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