Medicinal composition with function of protecting optic nerve and preparation method and application thereof

A protective effect and composition technology, which is applied in the field of pharmaceutical composition with optic nerve protection and its preparation and application, can solve the problems of not using wolfberry and breviscapine in combination, and achieve the effect of improving vision loss

Active Publication Date: 2012-07-25
成都中医大银海眼科医院股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, it is difficult for those skilled in the art to predict the effect of combining the two medicines.
At present, there is no relevant report on the combination of wolfberry and breviscapine

Method used

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  • Medicinal composition with function of protecting optic nerve and preparation method and application thereof
  • Medicinal composition with function of protecting optic nerve and preparation method and application thereof
  • Medicinal composition with function of protecting optic nerve and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation method of embodiment 1 medicine of the present invention

[0037] Take the wolfberry and scutellaria medicinal materials in the above parts by weight: 200g of wolfberry and 180g of scutellaria.

[0038]Add water to decoct wolfberry and scutellaria breviscapus and extract twice, each time with 8 times the amount of water, and extract for 2 hours. Filtrate, collect the filtrate, concentrate to an extract with a relative density of about 1.25 (60°C), add ethanol to a concentration of 80%, refrigerate for 24 hours, take the supernatant, recover ethanol, and concentrate to a relative density of about 1.25 (60°C) extract, add hydrochloric acid to adjust pH=2, keep warm at 50°C for 20 minutes, and let stand at room temperature. Among them, the acid water is collected from wolfberry to obtain wolfberry polysaccharide; the precipitate from scutellaria is obtained to obtain total flavonoids of scutellaria. Mix the two total flavonoids and dry under reduced pressu...

Embodiment 2

[0040] The preparation of embodiment 2 medicines of the present invention

[0041] Weigh the medicinal material (unit: g) according to the following table, and prepare according to the method of Example 1.

[0042] herbs

Embodiment 3

[0043] Embodiment 3 The preparation method of medicine of the present invention

[0044] Get the Lycium barbarum polysaccharide prepared in Example 1, the total flavonoids of scutellaria breviscapus (unit: g) according to the following weight ratio:

[0045] herbs

Party 14

Recipe 15

Party 16

Party 17

Party 18

Lycium barbarum polysaccharide

10

20

30

40

50

Total flavonoids of breviscapine

20

30

50

70

80

[0046] The polysaccharides of Lycium barbarum and the total flavonoids of breviscapus are mixed according to the conventional preparation method of traditional Chinese medicine to make various preparations, such as tablets, capsules, granules and the like.

[0047] Lycium barbarum polysaccharides and total flavonoids of scutellaria used in the present invention are not limited to those prepared by the method of Example 1, and can also be prepared according to other extr...

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PUM

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Abstract

The invention provides a medicinal composition with the function of protecting optic nerve, which is a preparation prepared by the following raw materials in part by weight: 40 to 400 parts of medlar and 45 to 480 parts of erigeron breviscapus. The medicament is used for treating optic neuropathy caused by liver and kidney deficiency and optic collateral stasis. The research shows that the medicinal composition has the function of protecting optic nerve. The invention is the optic nerve protection medicament for treating retinal diseases mainly comprising normal tension glaucoma, retinal vascular occlusion, diabetic retinopathy, ischemic optic neuropathy, macular degeneration, retinitis pigmentosa and Leber's disease.

Description

technical field [0001] The invention relates to a drug combination with optic nerve protection effect and a preparation method. Background technique [0002] The human optic nerve consists of approximately 1,000,000 optic nerve fibers. It is now believed that when 30% of the fibers are disordered, the static perimetry can detect abnormalities; when 50% of the fibers are disordered, it will affect the visual field and be detected by the dynamic perimetry. Optic nerve fibers are composed of axons of retinal ganglion cells extending to the lateral geniculate nucleus. Western medicine mostly divides optic atrophy into three types according to the location of optic nerve damage: 1. Descending optic atrophy (descending optic atrophy), which is caused by the orbital, intracanal, and intracranial optic nerve or optic chiasm, optic atrophy behind the cribriform plate. Atrophy of the optic nerve caused by damage to the bundle and the lateral geniculate body: also known as primary op...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61P9/10A61P27/06A61P27/02
Inventor 段俊国张艺苏国辉路雪婧张富文
Owner 成都中医大银海眼科医院股份有限公司
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