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Application of pharmaceutical composition containing tacrolimus in treating dry eye syndrome

A technology for tacrolimus and dry eye syndrome, which is applied in the application field of tacrolimus in the preparation of drugs for the treatment of dry eye syndrome and ocular surface immune-related diseases, and can solve the problem of large local side effects and ineffective treatment for the cause. and other problems, to achieve the effect of fast onset, avoiding first-pass effect and convenient use

Inactive Publication Date: 2010-07-21
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Aiming at the shortcomings of the current dry eye and ocular surface immune-related disease treatment drugs that have large local side effects or mainly rely on the systemic pharmacological effects of the drug and cannot effectively treat the etiology, provide a therapeutic effect, small side effects, mainly in the local area It is a pharmaceutical preparation that solves problems in the pathogenesis, physiology and pathology of dry eye disease, causes fundamental changes in the treatment of dry eye disease, and effectively treats ocular surface immune-related diseases.

Method used

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  • Application of pharmaceutical composition containing tacrolimus in treating dry eye syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 Formulation embodiment

[0020] Eye drops are prepared according to methods known in the art, containing the following ingredients;

[0021] tacrolimus eye drops

[0022] Tacrolimus 50mg

[0023] Hydroxypropyl methylcellulose 0.3g

[0024] Artificial tears 100ml

[0025] Simultaneously prepare cyclosporine A eye drops as contrast medicine by methods known in the art, contain following composition:

[0026] Cyclosporin A 50mg

[0027] Hydroxypropyl methylcellulose 0.3g

[0028] Artificial tears 100ml

Embodiment 2

[0029] Example 2 Therapeutic Effect of Tacrolimus Eye Drops on New Zealand Rabbits Suffering from Dry Eye Syndrome

[0030] 1. Preparation of dry eye model

[0031] Production of the dry eye model Healthy New Zealand white rabbits, half male and half male, weighing 2.0-2.5 kg. , with 3% pentobarbital sodium 1.5mL / kg intraperitoneal injection, general anesthesia. Under the operating microscope, the meibomian gland openings were directly cauterized with a fine electric knife, each for about 1 second, and then the nictitating membrane was surgically removed. After 5 weeks of modeling, observe the establishment of the model.

[0032] 2. Methods and Administration

[0033] The successfully modeled rabbit eyes (60 eyes), male and female, were randomly divided into tacrolimus treatment group, cyclosporine A treatment group, and control group, with 20 eyes in each group. The 0.05% tacrolimus eye drops (taerolimus FK506) prepared in Example 1 was used for internal drops, 2 times a ...

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Abstract

The invention belongs to a new application of a medicine, in particular relating to an application of immunosuppressive agent tacrolimus in medicine and preparation thereof for treating dry eye syndrome. Research shows that the tacrolimus eye drops have obvious effect in a model of animal dry eye syndrome, can relieve symptom of the patient such as sears optical, inflammation, itch, photophoby, foreign body sensation, asthenopia and the like, can improve vision of the patient, effectively improve the eye comfort level of the dry eye syndrome patient, and relieve the terrible emotion caused by discomfort eye part. The mechanism of action of the invention needs to be studied further.

Description

technical field [0001] The invention belongs to the new application of medicine, specifically, includes the application of tacrolimus in the preparation of medicines for treating dry eye and ocular surface immune-related diseases. Background technique [0002] There is a tear layer between the upper and lower eyelids of people, which contains substances that protect the eyes from infection. When people blink, the tears are evenly distributed on the surface of the eyeball, and the dust on the conjunctiva is cleaned to keep the eyes bright. Generally, the tear secretion of people decreases with age, so the incidence of dry eye disease is higher among the elderly. There are many factors that can cause dry eye syndrome, including: decreased tear secretion after middle-aged and old age, diseases of the eye itself, such as corneal degeneration, blepharitis, trachoma, etc.; various immune diseases and connective tissue diseases, such as rheumatoid arthritis , lupus erythematosus, ...

Claims

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Application Information

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IPC IPC(8): A61K31/436A61K9/08A61P27/02
Inventor 赵志全闫莹
Owner LUNAN PHARMA GROUP CORPORATION
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