Process for preparing fluticasone diproprionate superfine particles and product thereof

A technology of fluticasone propionate and fine particles, which is applied in the production of products, bulk chemicals, steroids, etc., can solve the problems of low bioavailability of human body, long development cycle, and difficult research and development, so as to facilitate human body absorption and product High quality, enhanced solubility and efficacy

Inactive Publication Date: 2010-08-11
CHINA NAT ACAD NANOTECH & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since fluticasone propionate is a kind of white crystalline powder with a relative molecular mass of 500.6, the drug is difficult to dissolve

Method used

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  • Process for preparing fluticasone diproprionate superfine particles and product thereof
  • Process for preparing fluticasone diproprionate superfine particles and product thereof
  • Process for preparing fluticasone diproprionate superfine particles and product thereof

Examples

Experimental program
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Embodiment

[0027] Embodiment: a kind of preparation technology of fluticasone propionate fine particle is characterized in that it comprises the following steps:

[0028] (1) configure fluticasone propionate solution: according to the ratio of organic solvent: fluticasone propionate 200:3, fluticasone propionate is fully dissolved in the organic solvent, so that the concentration of fluticasone propionate is: 1.5%; the dissolution temperature is controlled at 50 ℃;

[0029] (2) the fluticasone propionate solution 1 prepared in the step (1) is connected to the solution pump 2, and the working pressure is controlled to be 15MPa;

[0030] (3) Carbon dioxide feed: the CO in the cylinder 2 9. Enter the supercritical fluid anti-solvent equipment system through the booster pump 8, enter the crystallization kettle 4, control the flow rate at 10ml / min, control the starting temperature at 50°C, and the pressure at 15MPa;

[0031] (4) The fluticasone propionate solution configured in the above-me...

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Abstract

The invention discloses a process for preparing fluticasone diproprionate superfine particles, which comprises the following steps of: (1) preparing solution of fluticasone diproprionate; (2) connecting the solution of fluticasone diproprionate prepared by the step (1) with a solution pump; (3) feeding carbon dioxide; (4) rapidly spraying the solution of fluticasone diproprionate prepared by the step (1) into a crystallization kettle from a nozzle in a supercritical fluid anti-solvent equipment system with the solution pump; and (5) performing crystallization to separate the fluticasone diproprionate out. The fluticasone diproprionate superfine particles prepared by the process is characterized in that: the particles are white loose amorphous superfine particles of which an effective grain size d (0.5) is equal to 8.055mu m. The invention has the advantages that: the process for preparing the fluticasone diproprionate superfine particles by applying supercritical fluid crystallization technology is provided, is suitable for the fluticasone diproprionate superfine particles and improves the solubility and curative effect of the medicament.

Description

(1) Technical field: [0001] The invention relates to a process for preparing fluticasone propionate fine particles, in particular to a process for preparing fluticasone propionate fine particles by applying supercritical fluid crystallization technology. (two) background technology: [0002] As far as drugs are concerned, the size of particles can directly affect the degree of absorption and efficacy of drugs. Generally speaking, the smaller the drug particle, the larger the specific surface area, the easier it is to dissolve in the body fluid of the human body, and it can be completely absorbed by the human body, thus playing a good curative effect. Slow, it is difficult to be fully absorbed and utilized to achieve the desired drug effect. [0003] In the prior art, the refinement of drug particles is usually achieved by crushing method, ball milling method, solution method and supercritical fluid crystallization technology. However, the particle size distribution obtaine...

Claims

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Application Information

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IPC IPC(8): C07J3/00
CPCY02P20/141Y02P20/54
Inventor 魏海郑洪浩刘美
Owner CHINA NAT ACAD NANOTECH & ENG
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