Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Process for preparing fluticasone diproprionate superfine particles and product thereof

A technology of fluticasone propionate and fine particles, which is applied in the production of products, bulk chemicals, steroids, etc., can solve the problems of low bioavailability of human body, long development cycle, and difficult research and development, so as to facilitate human body absorption and product High quality, enhanced solubility and efficacy

Inactive Publication Date: 2010-08-11
CHINA NAT ACAD NANOTECH & ENG
View PDF0 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since fluticasone propionate is a kind of white crystalline powder with a relative molecular mass of 500.6, the drug is difficult to dissolve

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Process for preparing fluticasone diproprionate superfine particles and product thereof
  • Process for preparing fluticasone diproprionate superfine particles and product thereof
  • Process for preparing fluticasone diproprionate superfine particles and product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0027] Embodiment: a kind of preparation technology of fluticasone propionate fine particle is characterized in that it comprises the following steps:

[0028] (1) configure fluticasone propionate solution: according to the ratio of organic solvent: fluticasone propionate 200:3, fluticasone propionate is fully dissolved in the organic solvent, so that the concentration of fluticasone propionate is: 1.5%; the dissolution temperature is controlled at 50 ℃;

[0029] (2) the fluticasone propionate solution 1 prepared in the step (1) is connected to the solution pump 2, and the working pressure is controlled to be 15MPa;

[0030] (3) Carbon dioxide feed: the CO in the cylinder 2 9. Enter the supercritical fluid anti-solvent equipment system through the booster pump 8, enter the crystallization kettle 4, control the flow rate at 10ml / min, control the starting temperature at 50°C, and the pressure at 15MPa;

[0031] (4) The fluticasone propionate solution configured in the above-me...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Effective particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a process for preparing fluticasone diproprionate superfine particles, which comprises the following steps of: (1) preparing solution of fluticasone diproprionate; (2) connecting the solution of fluticasone diproprionate prepared by the step (1) with a solution pump; (3) feeding carbon dioxide; (4) rapidly spraying the solution of fluticasone diproprionate prepared by the step (1) into a crystallization kettle from a nozzle in a supercritical fluid anti-solvent equipment system with the solution pump; and (5) performing crystallization to separate the fluticasone diproprionate out. The fluticasone diproprionate superfine particles prepared by the process is characterized in that: the particles are white loose amorphous superfine particles of which an effective grain size d (0.5) is equal to 8.055mu m. The invention has the advantages that: the process for preparing the fluticasone diproprionate superfine particles by applying supercritical fluid crystallization technology is provided, is suitable for the fluticasone diproprionate superfine particles and improves the solubility and curative effect of the medicament.

Description

(1) Technical field: [0001] The invention relates to a process for preparing fluticasone propionate fine particles, in particular to a process for preparing fluticasone propionate fine particles by applying supercritical fluid crystallization technology. (two) background technology: [0002] As far as drugs are concerned, the size of particles can directly affect the degree of absorption and efficacy of drugs. Generally speaking, the smaller the drug particle, the larger the specific surface area, the easier it is to dissolve in the body fluid of the human body, and it can be completely absorbed by the human body, thus playing a good curative effect. Slow, it is difficult to be fully absorbed and utilized to achieve the desired drug effect. [0003] In the prior art, the refinement of drug particles is usually achieved by crushing method, ball milling method, solution method and supercritical fluid crystallization technology. However, the particle size distribution obtaine...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07J3/00
CPCY02P20/141Y02P20/54
Inventor 魏海郑洪浩刘美
Owner CHINA NAT ACAD NANOTECH & ENG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com