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Medicament compound for treating cancer bone metastasis and purposes thereof

A technology of bone metastasis and composition, which is applied in the field of medicine and can solve the problems that the inhibition and repair effects of cancer and bone metastasis are not very obvious.

Active Publication Date: 2012-05-23
魏华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there are still many defects in the above-mentioned prior art, and the inhibitory and repairing effects on various cancers and bone metastasis are not very obvious, and the improvement of the quality of life and the prolongation of the survival period of tumor patients need to be further improved. Therefore, it is urgent to continue to study , to overcome these defects

Method used

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  • Medicament compound for treating cancer bone metastasis and purposes thereof
  • Medicament compound for treating cancer bone metastasis and purposes thereof
  • Medicament compound for treating cancer bone metastasis and purposes thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Embodiment 1: preparation of pharmaceutical composition of the present invention

[0093] First, take 30ml 9% sodium chloride saline injection;

[0094] Then, 100 μg interleukin 2, 30 mg methotrexate injection, 2 μg gentamicin sulfate injection, 1 mg dexamethasone sodium phosphate injection and 20 μg scorpion venom injection were taken in terms of active ingredients. Then they are mixed and dissolved, and then injected locally on bone metastases and tumor sites, once every 5-7 days.

[0095] A 52-year-old female patient suffered from breast cancer (invasive ductal carcinoma of the right breast). In February 2007, the patient found an egg-sized mass on the outer upper limit of the right breast. In June 2007, the condition worsened and the mass ruptured. The patient refused Western medicine and continued to take traditional Chinese medicine. Afterwards, the ulceration area increased and there was a yellow discharge. out. In May 2008, numbness in the back, multiple pain...

Embodiment 2

[0097] Embodiment 2: preparation of pharmaceutical composition of the present invention

[0098] Take 30ml of 9% sodium chloride saline injection.

[0099] Take 120 μg of interleukin 2, 35 mg of methotrexate injection, 3 μg of gentamicin sulfate injection, 1.2 mg of dexamethasone sodium phosphate injection and 40 μg of scorpion venom injection based on active ingredients, mix and dissolve them, and then inject locally For bone metastases and tumor sites, once every 5-7 days.

[0100] A male patient, 43 years old, suffered from lung cancer (poorly differentiated adenosquamous carcinoma). In November 2003, a mass in the right lower lung was found in the physical examination, and the right lower lung was resected. After the postoperative course of the disease, he was diagnosed as "low-to-moderately differentiated adenosquamous carcinoma". After 6 weeks of routine chemotherapy, a re-examination of the head CT 4 months later found new metastases on the head, and he underwent whol...

Embodiment 3

[0118] Embodiment 3: preparation of pharmaceutical composition of the present invention

[0119] Take 30ml of 9% sodium chloride saline injection.

[0120] Take 80 μg of interleukin 2, 25 mg of methotrexate injection, 5 μg of gentamicin sulfate injection, 1.6 mg of dexamethasone sodium phosphate injection and 80 μg of scorpion venom injection in terms of active ingredients, mix and dissolve them, and then inject locally For bone metastases and tumor sites, once every 5-7 days.

[0121] A female patient, 54 years old, had paroxysmal dull pain or persistent soreness in the waist without obvious inducement in November 2005. In March 2006, the CT diagnosis was lung cancer, and the pathology showed "small cell adenocarcinoma" on March 15. Due to the side effects of multiple large doses of radiotherapy, chemotherapy, surgery, and regular oral painkillers, the patient is already very weak, with poor mental status, dyscrasia, painful expression, slightly pale complexion, forced post...

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Abstract

The invention relates to a medicament compound for treating cancer bone metastasis. The medicament compound comprises scorpion venom, interleukin 2, methotrexate, gentamycin sulfate, dexamethasone sodium phosphate and auxiliary medicines. The treatment by using the medicament compound is obviously superior to the treatment by using the traditional radiotherapy, chemotherapy and pamidronate disodium for injection. The medicament compound has remarkable restraining and repairing function for various cancers, metastatic tumors, cancer hydrothorax and ascites and bone metastasis, and the tumor resisting mode of the medicament compound has beneficial effects for improving the survival quality and prolonging the life time of tumor patients.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine. More specifically, the present invention relates to a pharmaceutical composition for treating cancer bone metastasis, and also relates to the use of the pharmaceutical composition. 【Background technique】 [0002] According to literature reports, nearly half of the newly diagnosed cancer patients will eventually develop bone metastases, most of which occur in the axial bone and lower limbs, especially in the hip joint area. Primary cancers prone to bone metastases are breast cancer, lung cancer, kidney cancer, rectal cancer, pancreatic cancer, gastric cancer, colon cancer, ovarian cancer, and prostate cancer. [0003] The formation of bone metastases is the result of the interaction between tumor cells and the host. It is generally believed that the way of metastasis can be: 1. Primary tumor cells infiltrate the surrounding tissues and enter the vasculature (blood and lymph); 2. Tumor cells f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/20A61K45/00A61P35/00A61P35/04A61K31/519A61K31/661A61K31/7036A61K35/64A61K35/646
Inventor 魏华
Owner 魏华
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