Preparation method of traditional Chinese medicine ultrafine formula particles

A technology of formula granules and traditional Chinese medicine, which is applied to pharmaceutical formulas, medical preparations containing active ingredients, and medical raw materials derived from ferns/filamentous plants, etc. Complex ingredients, etc., to achieve the effect of shortening extraction time, high technology content of products, and advanced production technology

Inactive Publication Date: 2010-09-08
湖南省中医药研究院
View PDF0 Cites 29 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emergence of single-flavored traditional Chinese medicine water has opened up a new path for the reform of traditional Chinese medicine decoctions. However, due to the neglect of the influence of co-decoction of traditional Chinese medicine decoctions on the dissolution of some medicinal ingredients and the addition of preservatives, As a result, the app cannot be promoted
From the 1970s to the 1980s, some domestic decoction pieces factories researched and produced Chinese medicine granular decoction pieces similar to decoction pieces in order to solve the problems of decoction in decoction pieces and low utilization rate of medicinal materials.
However, its price is relatively expensive. Some scholars believe that if the single-flavored Chinese medicine is extracted separately, taken together, and decocted together with several flavors of the traditional decoction piece decoction, whether the curative effect is consistent, and the ingredients of traditional Chinese medicine are complex, so it is difficult to extract all the ingredients. The representativeness of medicinal taste and the controllability of standardized quality standards need to be further studied

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of traditional Chinese medicine ultrafine formula particles
  • Preparation method of traditional Chinese medicine ultrafine formula particles
  • Preparation method of traditional Chinese medicine ultrafine formula particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Get 3950kg of dog ridge medicinal material, first process it into decoction pieces, then crush it into coarse powder, and sterilize it for subsequent use. Take 100g of coarse powder, adopt the superfine pulverization method, pulverize for 25 minutes to obtain dog spine superfine powder, and add water to the remaining 3850g of coarse powder for dynamic extraction twice, add water for the first extraction for 2 hours, add water for the second extraction for 1.5 hours, and extract the temperature Both are 80°C. The extract is sucked into the external circulation decompression concentrator, the vacuum degree is controlled between -0.06~-0.08MPa, the temperature is controlled at 70~80°C and concentrated under reduced pressure to a clear paste with a relative density of about 1.15 (measured at 60°C). Turn on the air inlet heater until the air inlet temperature reaches 160-180°C and the outlet temperature is 80-100°C, open the feed valve to feed the material, and spray dry to ...

Embodiment 2

[0034] Take 4160g of amomum medicinal material, first process it into decoction pieces, crush it into the coarsest powder, and sterilize it for later use. Take 100g of the coarse powder and adopt the superfine pulverization method to obtain superfine powder of amomum, add water to distill and extract the remaining 4060g for 6 hours, collect volatile oil, medicine liquid separately. Add β-cyclodextrin to the volatile oil, and adopt the saturated aqueous solution method for clathration. The specific operation steps are: take 4 times the amount of β-cyclodextrin, add water, heat to dissolve, and place it on a magnetic stirrer after cooling, at a constant temperature of 50°C. Add volatile oil (the volatile oil is formulated with ethanol in advance as an ethanol solution containing 50% volatile oil), stir for 3 hours, cool, refrigerate at 2-10°C for 24 hours, dry at 50°C, pass through 80 mesh, and set aside. Add water to the dregs after extracting volatile oil, extract dynamically ...

Embodiment 3

[0045] In order to prove the advantages of the present invention, a preliminary observation and study on the clinical curative effect of Kaiwei Jinshifang composed of 15 single-flavor ultrafine formula granules such as Ming Codonopsis, Atractylodes macrocephala, Poria cocos, and Fa Pinellia on the syndrome of fullness due to weakness of the spleen and stomach was carried out. The above 15 Chinese herbal medicines are separately prepared into ultrafine particles through the steps of ultrafine and extraction, and then the dosage is proportioned according to the traditional prescription.

[0046] To preliminarily observe the clinical curative effect and clinical safety of Kaiwei Jinshi Decoction Superfine Formula Granules on spleen and stomach weakness type fullness syndrome, and understand its curative effect on chronic superficial gastritis, functional dyspepsia and bile reflux esophagitis, etc. Effects on gastrointestinal motility.

[0047] Randomized, single-blind controlled ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a preparation method of traditional Chinese medicine ultrafine formula particles. The preparation method comprises the following steps that: single Chinese medicinal material or traditional Chinese medicine decoction pieces are partially ultrafine-crushed into ultrafine powder, the other parts are coarse-crushed, extracted, concentrated, dried and crushed to obtain dry extract powder, the ultrafine powder and auxiliary materials are added to obtain mixture, and the obtained mixture is mixed uniformly, palletized, granulated and subpackaged. The traditional Chinese medicine ultrafine formula particles is characterized in that the characteristics of the traditional Chinese medicine ultrafine decoction pieces of saving medicine materials and being controllable in quality and convenient in administration. Compared with the traditional Chinese medicine formula particles, the preparation method better preserves the medicinal properties of the traditional Chinese medicines, has the advantages of little used amount of auxiliary materials, convenient identification, benefit to measuring the content of index ingredients, preserves the advantages that the traditional Chinese medicine decoction piece can be added and reduced according to the disease and the traditional decoction has unique curative effect, also overcomes the defects of troublesome decoction and inconvenient administration, and has advanced technique and controllable quality. The invention also discloses a processing method of the Chinese medicinal material, which extracts the raw medicinal materials partially, carries out ultrafining treatment partially and then carries out mixing. The method can obvious improve the utilization ratio and leachability of the Chinese medicinal materials.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a preparation method of traditional Chinese medicine ultrafine formula granules. Background technique [0002] Chinese herbal decoction pieces are the material basis for decoction and syndrome differentiation and treatment. In clinical application, traditional Chinese medicine decoction pieces can be treated according to syndrome differentiation and treatment according to factors such as changes in the patient's condition, and the taste and dosage of the medicine can be flexibly tailored, thus showing strong vitality. With the development of the times and the advancement of science and technology, the disadvantages of decoction pieces of traditional Chinese medicine, inconvenience in taking, unstable quality, and poor sanitation have become increasingly prominent, which seriously restricts the development of clinical science of traditional Chin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K9/16A61K36/11A61K36/9064
Inventor 蔡光先张水寒唐正平杨瑛李跃辉杨永华黄江波丁志平罗新建蔡萍肖娟
Owner 湖南省中医药研究院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap