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Medicament for treating diabetic peripheral neuropathy and preparation method thereof

A technology for peripheral neuropathy and diabetes, applied in nervous system diseases, drug combinations, medical formulas, etc., can solve problems such as unsatisfactory effects, and achieve mild drug properties, long-lasting effects, and less toxic and side effects

Active Publication Date: 2012-08-22
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since the pathogenesis and pathological mechanism of diabetic peripheral neuropathy have not been fully elucidated, there is no specific treatment at home and abroad. Western medicine treats diabetic peripheral neuropathy in addition to controlling blood sugar, and often uses B vitamins, vasodilators, and analgesics. Drugs and anti-oxidation, supplementing neurotrophic factors and other symptomatic treatment, but the effect is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] 1) Weigh 15g of kudzu root, 6g of bellflower and 15g of yam and add water for reflux extraction. The amount of water added is 8 times the weight of kudzu root, bellflower and yam, and reflux extraction is performed twice. The first reflux extraction is 2 hours, and the second reflux extraction After 1.5 hours, the obtained extract was added with 90% ethanol for alcohol precipitation, and the ethanol was recovered to reach the clear paste 1;

[0053] 2) Weigh 18g of Atractylodes atractylodis, 15g of coix seed and 12g of Rhodiola rosea, crush them, pass through a 10-mesh sieve, soak them overnight with 70% ethanol, add 8 times the weight of the soaking solution in 70% ethanol for percolation extraction, and collect the percolation The liquid is centrifuged at a high speed at 5000 rpm to obtain the clear paste 2;

[0054] 3) Weigh 9 g of kelp, add water to carry out reflux extraction, the amount of water added is 20 times the weight of kelp, reflux extraction 2 times, each...

Embodiment 2

[0057] 1) Weigh 12g of kudzu root, 3g of bellflower and 12g of Chinese yam and add water to carry out reflux extraction. The amount of water added is 10 times the weight of kudzu root, bellflower and yam. Reflux extraction 3 times, each time for 1.5 hours, and add 95% ethanol to the obtained extract Carry out alcohol precipitation, reclaim ethanol, reach clear ointment 1;

[0058] 2) Weigh 15g of Atractylodes atractylodis, 12g of coix seed and 9g of Rhodiola rosea, crush them, pass through a 10-mesh sieve, soak them overnight with 50% ethanol, add 60% ethanol of 6 times the weight of the above soaking solution for percolation extraction, and collect the percolation After the liquid is centrifuged at 4000 rpm, the clear paste 2 is obtained;

[0059] 3) Weigh 6 g of kelp, add water to carry out reflux extraction, the amount of water added is 15 times the weight of kelp, reflux extraction 3 times, each time for 1.5 hours, add 95% ethanol to the obtained extract for alcohol precip...

Embodiment 3

[0062] 1) Weigh 18g of kudzu root, 6g of bellflower and 15g of Chinese yam and add water to carry out reflux extraction. The amount of water added is 12 times of the weight of kudzu root, bellflower and yam. Reflux extraction 4 times, 2 hours each time, add 95% ethanol to the obtained extract Carry out alcohol precipitation, reclaim ethanol, reach clear ointment 1;

[0063] 2) Weigh 18g of Atractylodes atractylodis, 15g of coix seed and 15g of Rhodiola rosea, crush them, pass through a 10-mesh sieve, soak them with 90% ethanol overnight, add 90% ethanol 10 times the weight of the above soaking solution for percolation extraction, and collect the percolation After the liquid is centrifuged at a high speed at 6000 rpm, the clear paste 2 is obtained;

[0064] 3) Weigh 12 g of kelp, add water to carry out reflux extraction, the amount of water added is 25 times the weight of kelp, reflux extraction 4 times, each time 2 hours, add 95% ethanol to the obtained extract for alcohol pre...

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Abstract

The invention relates to a medicament for treating diabetic peripheral neuropathy and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The medicament for treating diabetic peripheral neuropathy is mainly prepared from rhizome of Chinese atractylode, semen coicis, Chinese yam, roots of kudzu vine, Rhodiola rosea, kelp and platycodon Roots in certain weight proportions. As a traditional Chinese medicine composition, the medicament has the effects of supplementing qi and activating spleens, eliminating phlegm, resolving stases and activating collaterals, has a favorable effect on preventing and treating diabetic peripheral neuropathy, can obviously lighten the degrees of the diabetic peripheral neuropathy and has the functions of improving microcirculation and blood rheology, relieving symptom comprising pains, numbness, regulating immunities of organisms and the like and the advantages of safety and no toxic or side effect; the preparationmethod has the advantages of simple process and easy industrial generalization; granules, tablets or capsule prepared by the medicament not only keep some features of a decoction, but also have the advantages of convenient carrying and administration, stable quality, difficult deterioration and the like.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a medicine for treating diabetic peripheral neuropathy and a preparation method thereof. Background technique [0002] Diabetes is a common endocrine and metabolic disease. With the development of society and economy, changes in people's lifestyles and population aging, the incidence of diabetes is increasing year by year worldwide. It has become a disease after cardiovascular and tumors. , the third disease that threatens people's health and life. Diabetic Peripheral Neuropathy (DPN) is one of the most serious and common chronic complications of diabetes and one of the main causes of disability. According to statistics, the incidence of diabetic peripheral neuropathy in diabetic patients is 60% to 90%. Diabetic patients account for 40% to 60% of all non-traumatic low amputations, and the disease is protracted and difficult to heal, with high d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61P3/10A61P25/02
Inventor 柴可夫杨苏蓓王溶溶杨明华钱俊文
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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