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American-cockroach-extract-containing gelatin sponge and preparation method thereof

The technology of Periplaneta americana and gelatin sponge is applied in the field of medicine, which can solve the problems of unsatisfactory hemostasis effect and excessive bleeding, and achieve the effects of simple preparation method, alleviation of pain and reduction of bleeding rate.

Inactive Publication Date: 2010-09-22
耿福能
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gelatin sponge is essential for the treatment of postoperative oral surgery, nasal septal erosion, epistaxis, nose (sinus), endoscopic surgery and other surgical cavity packing. As a new type of packing, gelatin sponge is highly hydrophilic and highly expansive. , easy to use and other features are widely used, but the common gelatin sponge is found to have unsatisfactory hemostatic effect in clinical treatment, especially when it is taken out, it bleeds more

Method used

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  • American-cockroach-extract-containing gelatin sponge and preparation method thereof
  • American-cockroach-extract-containing gelatin sponge and preparation method thereof

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preparation example Construction

[0025] The preparation method of the gelatin sponge containing Periplaneta americana extract, comprises the following steps:

[0026] 1. Preparation of Periplaneta americana extract:

[0027] a, coarse crushing: the dried Periplaneta americana is pulverized, and the Periplaneta americana coarse powder is prepared for subsequent use;

[0028] b. Soaking: add 3 to 5 times the amount of water for every 100kg of coarse powder, and soak for 0.5 to 2 hours at a temperature of 70 to 78°C to prepare a coarse powder mixture for later use; among them, the preferred solution is: add water The amount is 4 times the amount, the soaking time is 1 hour, and the soaking temperature is 74°C;

[0029] c, three extractions: the coarse powder mixed solution is extracted three times by decocting, and when the coarse powder mixed solution is extracted for the first time, the extraction time is 7 to 9 hours; After adding 2 to 4 times the amount of water of the remaining liquid, carry out the secon...

Embodiment 1

[0038]Carry out according to the above method, coarsely crush the dried Periplaneta americana, add 300Kg water for every 100Kg coarse powder, soak for 0.5 hours, the temperature is about 70°C, extract three times, the first time is 7 hours; add water 200Kg for the second time, extract 5 hours; add 200Kg of water for the third time, and extract for 3 hours; combine the three extracts, filter, and concentrate the filtrate to a relative density of 1.05-1.08 (70°C), add ethanol with a concentration of 93% w / w to make an alcohol-containing The volume is 40%, 70 ℃ heat preservation and stirring for 20 minutes, let stand for 10 hours, discard the upper layer of grease, filter the lower layer of liquid medicine, the filtrate recovers ethanol, concentrates under reduced pressure to a relative density of 1.15 ~ 1.18 (70 ℃), and concentrates at normal pressure to Moisture ≤ 25% ointment, add purified water and glycerin to the Periplaneta americana extract according to the weight ratio of ...

Embodiment 2

[0040] Carry out according to the above method, coarsely crush the dried Periplaneta americana, add 500Kg water for every 100Kg coarse powder, soak for 2 hours, the temperature is about 78°C, extract three times, the first time is 9 hours; add water 400Kg for the second time, extract 7 hours; add 400Kg of water for the third time, and extract for 5 hours; combine the three extracts, filter, and concentrate the filtrate to a relative density of 1.22 to 1.25 (90°C), add ethanol with a concentration of 97% w / w to make alcohol-containing The amount is 55%, 90 ℃ heat preservation and stirring for 40 minutes, stand still for 14 hours, discard the upper layer of grease, filter the lower layer of liquid medicine, the filtrate recovers ethanol, concentrates under reduced pressure to a relative density of 1.27 ~ 1.30 (90 ℃), and concentrates at normal pressure to Moisture ≤ 35% ointment, add purified water and glycerol to the Periplaneta americana extract according to the weight ratio of...

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Abstract

The present invention discloses American-cockroach-extract-containing gelatin sponge, which mainly comprises an American-cockroach-extract-containing mixture and gelatin sponge, wherein the gelatin sponge per 1 x 1 x 0. 5cm unit area contains 0.5-1g of American-cockroach-extract-containing mixture. The preparation method of the invention is simple, gives full play to American cockroach extract, effectively improves hemostatic effects after oral surgery, nasal septum erosion, epistaxis, nose (nasal sinuses) and endoscopy surgery and the like, reduces the rate of bleeding, alleviates the pain of patients, and effectively shortens the course of the disease of the patients.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a gelatin sponge containing an extract of Periplaneta americana and a preparation method thereof. Background technique [0002] According to literature records, Periplaneta americana is the largest insect in the cockroach family. It is native to South America. Periplaneta americana is a traditional Chinese medicinal material. It is used as medicine with dried and fresh adults. Its nature is salty, poisonous and pungent. , has the functions of dispelling blood stasis, eliminating stagnation, detoxification, diuresis, and detumescence; it is mainly used to treat children with malnutrition, tonsillitis, body mass, carbuncle sores, and centipede and snake bites. [0003] In recent years, with the continuous development of science and technology, after years of research, it has been found that the epidermis of Periplaneta americana contains sclera and chitin, bromine, zinc, nickel, m...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/44A61K35/64A61P7/04
Inventor 耿福能刘彬黄婉怡胡若瑛杜江
Owner 耿福能
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