Anti-tumor traditional Chinese medicine composition and preparation method and application thereof

A technology of anti-tumor effect and tumor drug, applied in the field of medicine, can solve the problems of limited curative effect and adverse reactions, and achieve the effect of strong operability, good analgesic effect, and scientific and reasonable proportioning

CN101850032AActive Publication Date: 2010-10-06雷允上药业集团有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2010-10-06

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Abstract

The invention discloses an anti-tumor Chinese medicine composition and a preparation method and application thereof. The Chinese medicine composition is prepared with the following raw materials in parts by weight: 10-100 parts of ligusticum wallichii, 10-200 parts of corydalis amabilis, 1-50 part(s) of prepared monkshood, 10-300 parts of daphne giraldii nitsche, 10-100 parts of gentiana macrophylla and 1-50 part(s) of venenum bufonis. The traditional Chinese medicine composition provided by the invention is prepared according to the formula of the traditional Chinese medicine based on the theory of the traditional Chinese medicine and the theory of syndrome differentiation and treatment, and the results of in vivo and in vitro experiments show that the traditional Chinese medicine composition provided by the invention has the functions of inhibiting the growth of the tumor cell and promoting the apoptosis of the tumor cell, and has a strong function of killing a variety of tumor cells. Therefore, the scope of application of the traditional Chinese medicine composition is wide. Moreover, the extract of the traditional Chinese medicine composition provided by the invention can be prepared as various preparations, can be taken conveniently in clinical treatment and has no toxic and side effect in the long-term use.
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Description

technical field

[0001] The invention relates to a medicine, in particular to a traditional Chinese medicine composition, its preparation method and its application in the preparation of medicines for treating tumor diseases. Background technique

[0002] Malignant tumors have become a common and major disease that seriously threatens human life and quality of life. According to the "World Cancer Report" published by the World Health Organization in April 2004, the next few years will be the year of high incidence of global tumors, and the incidence rate will increase by 50%.

[0003] The causes of malignant tumors mainly include: environmental pollution of the body, chemical pollution, such as chemical toxins, ionizing radiation, free radical toxins, microorganisms, such as bacteria, fungi, viruses, etc. and their metabolic toxins, genetic characteristics, endocrine imbalance, immune dysfunction, etc. Various carcinogens and carcinogenic factors lead to cancerous changes in...

Examples

Embodiment 1

[0037] 1. Composition of raw materials of traditional Chinese medicine compound composition:

[0038] 50 grams of Chuanxiong, 100 grams of Xiawu, 20 grams of Zhichuanwu, 120 grams of Zushima, 50 grams of Gentiana chinensis, and 10 grams of toads.

[0039] 2. Preparation method of Chinese medicine compound composition preparation:

[0040] (1) Take 100 grams of Xiawu, 20 grams of Zhichuanwu, 10 grams of Chansu, and 120 grams of Zushima in parts by weight, and use 8 times the concentration of 80% ethanol to reflux extract twice for 2 hours each time, and the extract Recover ethanol to obtain a thick paste, dry, pulverize, and set aside;

[0041] (2) Take 50 grams of Rhizoma Chuanxiong and 50 grams of Gentiana chinensis in parts by weight, add 8 times the amount of water to reflux and extract twice, the first time is 3 hours, and the second time is 2 hours, the combined extracts are concentrated to obtain a thick paste and dried , pulverized, spare;

[0042] (3) Take the extract...

Embodiment 2

[0044] 1. Composition of raw materials of traditional Chinese medicine compound composition:

[0045] Chuanxiong 100g, Xiawu 200g, Zhichuanwu 30g, Zushima 280g, Gentiana 100g, and Toad Su 40g.

[0046] 2. Preparation method of Chinese medicine compound composition preparation:

[0047] (1) Get 200 grams of Xia Wu, 30 grams of Zhichuan Aconitum, 40 grams of Chansu, and 280 grams of Zushima in parts by weight, and use 8 times the concentration of 80% ethanol to reflux extract twice for 2 hours each time, and extract Recover ethanol to obtain a thick paste, dry, pulverize, and set aside;

[0048] (2) Take 100 grams of Rhizoma Chuanxiong and 100 grams of Gentiana quinquefolium in parts by weight, add 8 times the amount of water to reflux and extract twice, the first time for 3 hours, and the second time for 2 hours, combine the extracts, concentrate, get a thick paste, and dry , pulverized, spare;

[0049] (3) Take the extract powder diluent lactose or corn starch obtained in s...

Embodiment 3

[0051] 1. Composition of raw materials of traditional Chinese medicine compound composition:

[0052] 20 grams of Chuanxiong, 20 grams of Xiawu, 5 grams of Zhichuanwu, 20 grams of Zushima, 10 grams of Gentiana chinensis, and 5 grams of toads.

[0053] 2. Preparation method of Chinese medicine compound composition preparation:

[0054] (1) Get 20 grams of Xiawu, 5 grams of Zhichuanwu, 5 grams of Toad, and 20 grams of Zushima in parts by weight, and use 6 times the concentration of 85% ethanol to reflux extract twice for 2 hours each time, and the extract Recover ethanol to obtain a thick paste, dry, pulverize, and set aside;

[0055] (2) Take 20 grams of Rhizoma Chuanxiong and 10 grams of Gentiana chinensis in parts by weight, add 6 times the amount of water to reflux and extract twice, the first time is 3 hours, and the second time is 2 hours, the combined extracts are concentrated to obtain a thick paste and dried , pulverized, spare;

[0056] (3) The extract obtained in s...