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Application of skeleton protein source polypeptide in preparing medicines for restraining invasion and transfer of colorectal cancer cells

A skeletal protein, cancer cell technology, applied in drug combinations, peptide/protein components, anti-tumor drugs, etc., can solve the problem of inseparable from cancer cell motility and other problems, and achieve the effect of invasion and metastasis inhibition and invasion and metastasis.

Inactive Publication Date: 2010-10-06
AFFILIATED HOSPITAL OF NANTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this complex series of steps is inseparable from the cancer cell's own motility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] An application of a skeleton protein-derived polypeptide in the preparation of a drug for inhibiting the invasion and metastasis of colorectal cancer cells, the skeleton protein-derived polypeptide is a V+Repeat fusion polypeptide of the following amino acid series:

[0017] NKAALL DQIREGAQLKKV GRDALLDQ IRQGIQLKSV

[0018] SHGYGGKFGV EQDRMDKSAV GHEYQSKLSK HCSQVDSVRG

[0019] FGGKFGVQMD RVDQSAVGFE YQGKTEKHAS QKDYSSGFGG

[0020] KYGVQADRVD KSAVGFDYQG KTEKHESQRD YSKGFGGKYG

[0021] IDKDKVDKSA VGFEYQGKTE KHESQKDYVKGFGGKFGVQT

[0022] DRQDKCALGW DHQEKLQLHE SQKDYKTGFG GKFGVQSERQ

[0023] DSAAVGFDYK EKLAKHESQQ DYSKGFGGKY GVQKDRMDKN

[0024] ASTF.

[0025] Experimental evidence:

[0026] 1. Peptide Design and Preparation

[0027] Human N-WASP consists of 505 amino acids, and the V region of N-WASP consists of 36 amino acids from 405th to 422nd and 433rd to 450th. The amino acid sequences are NKAALLDQIREGAQLKKV and GRDALLDQIRQGIQLKSV. Except for the V region, the carbox...

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PUM

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Abstract

The invention discloses an application of skeleton protein source polypeptide in preparing medicines for restraining the invasion and the transfer of colorectal cancer cells. The V+Repeat fused polypeptide has very obvious restraining action on the invasion and the transfer of the colorectal cancer.

Description

Technical field: [0001] The invention relates to the application of a skeleton protein-derived polypeptide in the preparation of a drug for inhibiting the invasion and metastasis of colorectal cancer cells. Background technique: [0002] The invasion and metastasis of malignant tumors such as colorectal cancer is a multi-step complex process, generally including the local proliferation and expansion of cancer cells, separation and shedding, neovascularization of tumor tissue, cancer cells entering the circulation, cancer cells degrading vascular basement membrane escape, etc. out cycle and subsequent positioning growth, etc. However, this complex series of steps is inseparable from the cancer cell's own motility. The movement of cancer cells, including pseudopodia-like stretching of cell membranes, changes in membrane fluidity and cell polarity, is the basic common feature of each step of cancer cell invasion and metastasis. The motility of cancer cells depends on the poly...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P1/00A61P35/00
Inventor 朱建伟马利林
Owner AFFILIATED HOSPITAL OF NANTONG UNIV
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