The invention discloses an agastache rugosus plant fermentation solution and a preparation method thereof and relates to the technical field of fermentation solutions. The agastache rugosus plant fermentation solution comprises the following components: 5-7 parts of dry agastache rugosus, 5-7 parts of dry fructus amomi rotundus, 5-7 parts of dry fructus crataegi, 0.5-1 part of honey, 0.5-1 part of oligosaccharide, 0.5-1 part of glucose powder, 0.02-0.04 part of dry yeast and 50 parts of water. The preparation method of the agastache rugosus plant fermentation solution comprises the following steps: crushing the dry agastache rugosus, the dry fructus amomi rotundus and the dry fructus crataegi, then blending crushed dry agastache rugosus, dry fructus amomi rotundus and dry fructus crataegi with the honey, the oligosaccharide, the glucose powder and the dry yeast according to a ratio by using the water, adding the materials into a tank, sealing and fermenting until vinegar flavor is emitted, then processing, extracting and purifying a fermentation solution by using a supercritical fluid extraction separation technology to obtain the agastache rugosus plant fermentation solution. The fermentation solution is formed by fermenting pure traditional Chinese medicines, has vinegar flavor, is delicious with slight sweetness and sour, is good in taste, is popular to children, and is free of side effects after being taken. Clinical test shows that the fermentation solution is used for treating anorexia; the curative effect is obvious; the total effective rate is 95%.