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Usage of isothiocyanate in preparing medicine for preventing from tumor invasion and metastasis

A technology of isothiocyanate and benzyl isothiocyanate, which is applied in the field of preparation of isothiocyanate to prevent and treat tumor invasion drugs, and can solve problems such as unreported, tumor invasion, etc.

Active Publication Date: 2012-06-27
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a lot of research has been done on the anti-cancer effects of isothiocyanates, the effects of isothiocyanates on tumor invasion and metastasis have not been reported yet.

Method used

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  • Usage of isothiocyanate in preparing medicine for preventing from tumor invasion and metastasis
  • Usage of isothiocyanate in preparing medicine for preventing from tumor invasion and metastasis
  • Usage of isothiocyanate in preparing medicine for preventing from tumor invasion and metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The use of benzyl isothiocyanate in the preparation of drugs for preventing and treating tumor invasion and metastasis, the molecular formula of benzyl isothiocyanate is C 6 h 5 CH 2 NCS; the structural formula is:

[0034]

[0035] The tumors are lung cancer, liver cancer, esophageal cancer, gastric cancer, colon cancer, pancreatic cancer, breast cancer, cervical cancer, ovarian cancer, prostate cancer, penile cancer, melanoma, brain tumor, oral cavity tumor, ear cancer, nasopharyngeal cancer and / or tongue cancer.

Embodiment 2

[0037] The use of phenylethyl isothiocyanate in the preparation of drugs for the prevention and treatment of tumor invasion and metastasis, the molecular formula of phenylethyl isothiocyanate is C 6 h 5 CH 2 CH 2 NCS; the structural formula is:

[0038]

[0039] The tumors are lung cancer, liver cancer, esophageal cancer, gastric cancer, colon cancer, pancreatic cancer, breast cancer, cervical cancer, ovarian cancer, prostate cancer, penile cancer, melanoma, brain tumor, oral cavity tumor, ear cancer, nasopharyngeal cancer and / or tongue cancer.

[0040] Benzyl isothiocyanate and phenylethyl isothiocyanate are added with pharmaceutically acceptable excipients to make various dosage forms according to conventional methods, such as liquid injections of various specifications, powder injections, emulsions for injection, tablets, pills, Capsules, ointments, creams, patches, liniments, powders, sprays, implants, drops, suppositories, ointments, candies, etc.

[0041] The r...

Embodiment 3

[0043] Isothiocyanates inhibit the growth of various tumor cells

[0044]Through the MTT method, it was found that benzyl isothiocyanate and phenylethyl isothiocyanate can effectively inhibit the growth of various tumor cells such as lung cancer, breast cancer, and leukemia. In particular, by comparing the effects on the growth of human high-metastatic lung cancer cell L9981 and low-metastatic lung cancer cell NL9980, it is found that its inhibitory effect on high-metastatic lung cancer cell L9981 is stronger. 50% inhibitory concentration (IC) of benzyl isothiocyanate (BITC) on L9981 cells 50 ) is 5.0μM, while the IC acting on NL9980 cells 50 8.8μM; IC of phenylethyl isothiocyanate (PEITC) on L9981 cells 50 is 9.7μM, while the IC on NL9980 cells 50 is 12.2 μM. This result shows that it has a selective inhibitory effect on highly metastatic lung cancer cells. Dose growth curve see figure 1 with figure 2 , 50% growth inhibitory concentration (IC 50 ) see Table 1.

[00...

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PUM

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Abstract

The invention discloses the usage of isothiocyanate in preparing a medicine for preventing from tumor invasion and metastasis. The usage proves that the isothiocyanate can effectively preventing from tumor cells invasion and metastasis by means of cytobiology and molecular biology. The isothiocyanate effectively restrains the growth and the invasion of the tumor cells, induces the tumor cells to be apoptosis, adjusts and controls the correlative genes of the tumor metastasis, induces the period of the tumor cells to be arrested, and damages the tumor cells caused by oxidation. Therefore, the isothiocyanate can be taken as an effective component to prepare medicines, foods, health care products and cosmetics for preventing from the tumor invasion and metastasis.

Description

technical field [0001] The invention belongs to the field of medical applications, and relates to the use of isothiocyanate in preparing drugs for preventing and treating tumor invasion. Background technique [0002] The morbidity and mortality of cancer in my country are on the rise rapidly. Cancer has caused great suffering to patients and their families, and has taken up a lot of social resources and wealth. Cancer has become an increasingly serious public health problem facing mankind. Governments of various countries have invested a lot of human and material resources in order to make breakthroughs in the field of cancer research. [0003] At present, the main treatment methods for cancer are surgery, radiotherapy, chemotherapy and biological therapy. Surgical treatment is the most effective treatment. However, the vast majority of patients are already in the middle or late stage when they see a doctor, and they miss the opportunity for surgical treatment. Radiation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/26A61P35/00A61P35/02A61P35/04
Inventor 徐克周清华吴骧闫慧琴
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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