Application of atractylon to preparation of anti-liver cancer molecular target medicine

Abstract

The invention discloses application of atractylon shown as a structural formula (I) to preparation of an anti-liver cancer molecular target medicine. Seen from results of cell experiments and animal experiments provided by the invention, the atractylon has the property and the effect of inhibiting invasion and metastasis of liver cancer cells, which are found by the invention for the first time; in addition, the animal experiments further prove that the atractylon has the function of inhibiting growth of liver tumors in a nude mouse, has a significant anti-tumor effect on the nude mouse, and reaches an unexpected technical effect in the field. These results indicate that the atractylon can be applied to preparation of the anti-liver cancer molecular target medicine and has good applicationprospect and good application value.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the new medical application of the traditional Chinese medicine monomer Atractylon, in particular to the application of Atractylon in the preparation of anti-liver cancer molecular target drugs. Background technique [0002] Primary liver cancer is one of the malignant tumors with the highest mortality rate, which brings great harm to the health of people all over the world. According to the statistics of the World Health Organization in 2013, the number of deaths caused by primary liver cancer was 775,517, and the death toll in my country accounted for more than 50%, which is the hardest hit area of ​​primary liver cancer. [0003] At present, there is no specific drug for the treatment of liver cancer, and a comprehensive treatment plan is basically adopted, such as the use of the targeted drug Sorafenib, chemotherapy, and comprehensive symptomatic treatment, so as to control ...

AI Technical Summary

Problems solved by technology

However, this study is a bit simple and not rigorous enough, and the mechanism of action has not been studied in depth. The specific defects are mainly reflected in the following two aspects: First, the study only targets liver cancer cells HepG2

There is no research on other liver cancer cells (such as MHCC97H, SMCC7721, etc.), and it cannot prove that it is necessarily effective on other liver cancer cells, so the results are somewhat accidental and not convincing.

Second, no animal experiments were conducted

[0010] Since there is currently no specific drug for liver cancer, it is necessary to find new potential molecular target drugs through basic research. Traditional Chinese medicine provides an important reference for finding molecular target drugs

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