Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized 129Xe

A polarized gas and signal technology, applied in the evaluation of respiratory organs, application, diagnostic recording/measurement, etc., can solve problems such as early diagnosis problems

Inactive Publication Date: 2010-10-20
MEDI PHYSICS IN
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Early diagnosis of heart failure in which the ejection fraction may be normal, especially in heart failure due to diastolic dysfunction remains a problem

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  • Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized 129Xe
  • Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized 129Xe
  • Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized 129Xe

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Embodiment Construction

[0043] The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which embodiments of the invention are shown. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Like numbers refer to like elements throughout. In the drawings, layers, regions or features may be exaggerated for clarity. Dashed lines in the figures indicate optional features or operations unless otherwise specified.

[0044] Polarized gases can be collected, frozen, thawed, and used in MRI and NMR spectroscopy applications, as known to those skilled in the art. Frozen collection and thawing may not be required in certain embodiments. To simplify the description, the term "frozen polarized gas" refers to a polarized gas that has been frozen into a solid state. The term "liquid polarized gas" refers to a polarized gas that has been liquefied into a liquid state, or ...

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Abstract

Methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and / or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and / or diagnosing a respiratory, cardiapulmonary disorder or disease such as chronic heart failure, and / or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.

Description

[0001] This application is a branch of the application whose international filing date is January 30, 2004, the international application number is 200480003223.8, and the title of the invention is "Method for In vivo Evaluation of Lung Physiology and / or Function Using Polarized 129Xe NMR Signals" case application. technical field [0002] The present invention relates to magnetic resonance imaging ("MRI") and MR spectroscopy using hyperpolarized noble gases. More specifically, the present invention relates to techniques for estimating certain conditions in the body using polarized noble gases. Background technique [0003] Chronic heart failure (CHR) appears to affect a relatively large and possibly growing segment of the population. See, eg, The Task Force on Heart Failure of the European Society of Cardiology. Guidelines for the Diagnosis of Heart Failure, 16 Eur. Heart Jnl., p. 741-751 (1995). In addition, many elderly heart failure patients are women, and a more commo...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055A61B5/08G01R33/485
Inventor B·德里惠斯M·哈尔C·马雷利S·曼松J·沃尔伯
Owner MEDI PHYSICS IN
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