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Dehumidifying itching-relieving gels and preparation method thereof

A technology of gel and cnidium, which is applied in the field of antibacterial external medicine and its preparation, can solve problems such as inconvenient use, loss of market competitiveness, and unreasonable selection of substrates

Active Publication Date: 2010-10-20
SICHUAN DEFENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional Chinese medicine has a concept of "treating internal diseases externally". The traditional treatment methods include plaster, fumigation, moxibustion, foot bath, etc.: plaster is the basic therapy, and the ancients called it thin paste. Unreasonable, inconvenient to use, often cause skin allergies, and gradually lose market competitiveness: gel is a kind of semi-solid jelly containing liquid and its drying system (dry glue) containing two or more components. General term for molecular network system

Method used

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  • Dehumidifying itching-relieving gels and preparation method thereof
  • Dehumidifying itching-relieving gels and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] ① Add 167g Cnidium Fructus Cnidii, 19g Zanthoxylum bungeanum and 37g Atractylodes atractylodes with 16 times the amount of water, distill and extract for 6 hours, collect the volatile oil, filter the medicinal liquid and store it in another container; Ginseng, 74g Polygonum cuspidatum, 74g Viola chinensis, 93g Kochia scoparia, 56g sage and 56g capillary, add water and decoct twice, one hour each time, add 12 times the amount of water for the first time, add 8 times the amount of water for the second time , merge the decoction and merge with the medicinal liquid after distillation, concentrate to a relative density of 1.2 to 1.3, and this density is measured at 60°C to obtain (I);

[0089] ② Grind 15g borneol, 1g ethylparaben, 100g glycerin, 95% ethanol (the density of this ethanol is 0.79g / ml at normal temperature) 50ml, and add the volatile oil extracted in step ① and mix well to obtain (II);

[0090]③Take 20g of Carbomer-940 powder, sprinkle it on the surface of disti...

Embodiment 2

[0093] ① Add 167g Cnidium Fructus Cnidii, 19g Zanthoxylum bungeanum and 37g Atractylodes atractylodes with 16 times the amount of water, distill and extract for 6 hours, collect the volatile oil, filter the medicinal liquid and store it in another container; Ginseng, 74g Polygonum cuspidatum, 74g Viola chinensis, 93g Kochia scoparia, 56g sage and 56g capillary, add water and decoct twice, one hour each time, add 12 times the amount of water for the first time, add 8 times the amount of water for the second time , combine the decoction and combine with the distilled medicinal liquid, add 95% ethanol to make the alcohol content reach 70%, let it stand for 20 hours, filter, recover the ethanol, concentrate to a relative density of 1.2-1.3, and the density is 60°C Measure, get (I);

[0094] ② Grind 15g borneol, 1g ethylparaben, 100g glycerin, 95% ethanol (the density of this ethanol is 0.79g / ml at normal temperature) 50ml, and add the volatile oil extracted in step ① and mix well ...

Embodiment 3

[0098] ① Add 167g Cnidium Fructus Cnidii, 19g Zanthoxylum bungeanum and 37g Atractylodes atractylodes with 16 times the amount of water, distill and extract for 6 hours, collect the volatile oil, filter the medicinal liquid and store it in another container; Ginseng, 74g Polygonum cuspidatum, 74g Viola chinensis, 93g Kochia scoparia, 56g sage and 56g capillary, add water and decoct twice, one hour each time, add 12 times the amount of water for the first time, add 8 times the amount of water for the second time , combined the decoction and combined with the distilled medicinal liquid, put it on the treated macroporous adsorption resin column, after the medicinal liquid was absorbed, add 70% ethanol to elute, collect the eluate, recover ethanol, concentrate to a relative density of 1.2 ~1.3, the density is measured at 60°C to obtain (I);

[0099] ② Grind 15g borneol, 1g ethylparaben, 100g glycerin, 95% ethanol (the density of this ethanol is 0.79g / ml at normal temperature) 50ml...

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Abstract

The invention relates to dehumidifying itching-relieving gels and a preparation method thereof, wherein the preparation method is characterized by comprising the following steps of: extracting volatile oil from common cnidium fruit, pricklyash peel and rhizoma atractylodis, boiling medicine dregs and other Chinese traditional medicines (except borneol) for two times in total, filtering, merging medicine liquids, and concentrating into thick paste, or removing partial impurities of the concentrated medicine liquid by using a water ethanol method, and concentrating the medicine liquid into the thick paste, or purifying the medicine liquid through macroporous adsorption resin, eluting through dilute ethanol, and concentrating an eluent into the thick paste; grinding the borneol into fine powder, grinding with an antiseptic, such as ethylparaben, a humectant, such as one or more of glycerin, polyethylene glycol, sorbitol and glycerol as well as a cosolvent, such as ethanol, and adding the volatile oil for uniformly grinding; preparing a gel matrix, such as Carbomer, tragacanth, pectin, gelatin, hydroxypropyl methyl cellulose and hydroxymethyl cellulose into certain concentration by using water; and uniformly mixing the three parts, and regulating the pH to a proper range by using a pH regulator, such as triethanolamine and the like to obtain the dehumidifying itching-relieving gel. The invention enriches drug administration preparation forms and satisfies the dosage requirement of vast patients.

Description

technical field [0001] The invention mainly relates to an antibacterial external medicine and a preparation method thereof, and mainly relates to a dehumidification and antipruritic gel and a preparation method thereof. Background technique [0002] Chushi Zhiitch ointment has been listed, but its disclosed invention patent (patent number: ZL200510022093.9) is mainly an ointment with a single dosage form, which makes the medication single and cannot meet the medication requirements of the majority of patients. Simultaneously, through searching, do not find any report about dehumidification and antipruritic gel of the present invention. [0003] Traditional Chinese medicine gel is a new type of pharmaceutical dosage form. The Chinese Pharmacopoeia 2010 Edition defines gel as "gel refers to the semi-solid or thick liquid preparation with gel properties made from extracts and suitable substrates." . Traditional Chinese medicine gel is suitable for drug administration on the s...

Claims

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Application Information

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IPC IPC(8): A61K36/86A61K9/00A61P17/00A61P17/04A61K31/045
Inventor 王俊贤唐萍
Owner SICHUAN DEFENG PHARMA CO LTD
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