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Thieno pyridinone derivative containing piperazidine and preparation method and applications thereof

A technology of pyridine and piperazine, applied in the field of medicine, can solve the problems of poor selectivity, toxic and side effects, low specificity and the like

Inactive Publication Date: 2010-10-20
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Traditional chemotherapeutic drugs have obvious clinical therapeutic effects, but their disadvantages are: low specificity and poor selectivity, leading to obvious toxic and side effects, and prone to serious tumor multi-drug resistance, which limits clinical application. Looking for safe and effective anti-tumor drugs Drugs have always been the pursuit of the pharmaceutical industry

Method used

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  • Thieno pyridinone derivative containing piperazidine and preparation method and applications thereof
  • Thieno pyridinone derivative containing piperazidine and preparation method and applications thereof
  • Thieno pyridinone derivative containing piperazidine and preparation method and applications thereof

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Abstract

The invention belongs to the technical field of antineoplastic medicines and provides thieno pyridinone derivative with the structure of the general formula I and salt thereof which are acceptable in pharmacy, wherein n, R1 and R2 are defined in the specification. The invention also relates to a preparation method of the compound, and discloses pharmaceutical composites using the compound or the salt thereof which are acceptable in pharmacy as active ingredient and the applications of the pharmaceutical composites used as the antineoplastic medicines.

Description

technical field The invention belongs to the technical field of medicine, more specifically, relates to a class of compounds with anti-malignant tumor effects and a preparation method thereof. Background technique Tumor is a common disease that threatens human life. According to statistics, the total number of cancer deaths in the world reaches 7 million people every year. In my country, more than 1 million people die from cancer every year, and gradually increase. It has become the first cause of death in urban population. Traditional chemotherapeutic drugs have obvious clinical therapeutic effects, but their disadvantages are: low specificity and poor selectivity, leading to obvious toxic and side effects, and prone to serious tumor multi-drug resistance, which limits clinical application. Looking for safe and effective anti-tumor drugs Drugs have always been the pursuit of the pharmaceutical industry. Contents of the invention One object of the present invention is to...

Claims

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Application Information

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IPC IPC(8): C07D495/04A61K31/496A61P35/00A61P35/02
Inventor 刘颖刘默刘冰妮刘登科周云松白玫王景阳
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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