55results about How to "Strong inhibition rate" patented technology

The invention discloses a D-type amino acid containing antimicrobial peptide analog. The D-type amino acid containing antimicrobial peptide analog is obtained through separately introducing D-type amino acids to a hydrophilic surface and a hydrophobic surface of a natural antimicrobial peptide Anoplin and modifying the hydrophilic surface and the hydrophobic surface. Shown by determination on minimal inhibitory concentration to common standard bacteria, biomembrane formation inhibiting tests and enzymolysis stability tests, synthesized hydrophilic-surface D-type peptide analogs all reserve the antimicrobial activity of the original stock peptide and meanwhile represent relatively high bacterial biomembrane formation inhibiting capability. The chymotrypsin tolerance is enhanced by 10 times compared with that of the stock peptide Anoplin. Although the antimicrobial activity of synthesized hydrophobic-surface D-type substituted analogs is lowered to some extent compared with that of the stock peptide, the stability of the synthesized hydrophobic-surface D-type substituted analogs is improved remarkably; and compared with the stock peptide, the trypsin tolerance is improved by 10<4> to 10<5> times, and the chymotrypsin tolerance is improved by 10<2> times. Therefore, the synthesized D-type amino acid containing analog has a very good application prospect in the aspect of preparation of long-acting clinical antibacterials.

The invention belongs to the technical field of drugs for resisting malignant tumor and provides nitrogen-containing heterocyclic thienopyridine compounds with the structure shown as a general formula I and salts thereof, wherein R1 is hydrogen, and C1-C4 are alkanoyloxy substituted by alkyl; and R2 is nitrogen-containing six-membered heterocycle, i.e. benzoazo six-membered heterocycle. The invention further relates to a method for preparing the compounds, and also discloses drug compositions taking the compounds or the salts thereof as the active effective components and application thereof as drugs for resisting malignant tumor.

The invention relates to an alpha-glucosidase inhibitor and a preparation method thereof. The preparation method comprises the following steps: culturing and activating a strain; culturing seeds; inoculating the stain into a shake flask for fermentation culture; collecting fermentation liquor; and performing separation and purification to obtain the alpha-glucosidase inhibitor. In the invention, the alpha-glucosidase inhibitor is obtained by microbial fermentation and can be used for developing hypoglycemic medicaments and provide a new tool for further research on active site of enzymes such as the alpha-glucosidase.

The invention belongs to the field of microbial herbicides and particularly relates to weed suppression fungus screened from passion fruit rhizosphere soil. Lettuce (compositae), barnyard grass (gramineae) and lysimachia barystachys (gramineae) are taken as receptors separately, biological test is carried out on the weed suppression ability of a fungus strain fermentation liquid, and the condition that the weed suppression fungus has a very high inhibition rate on root length and plant height of two receptors is found out. The condition that protocatechuic acid, p-hydroxybenzoic acid, vanillic acid, salicylic acid and cinnamic acid contain phenolic acid with a weed suppression effect is detected in the fermentation liquid. The strain is named FJ-01-BXG-08. The analysis and identification results on the morphology and ITS sequence of the strain show that the strain is one of Aspergillus sydowii (aspergillus sydowii), and strong weed suppression fungus aspergillus sydowii (Aspergillus sydowii) is screened from eucalyptus soil for the first time.

A spot-removing ointment is prepared from 15 Chinese medicinal materials including Dragon's blood, notoginsent, peach kernel, Chinese angelica root, etc through pulverizing part of them ready for use, extracting volatile oil from another part of them ready for use, recovering alcohol, filtrate of others and ready for use, mixing the rest ingredients with the decoction dregs after extracting volatile oil, decocting ready for use, and adding the above-mentioned extracted substance to the extract matrix. Its advantages are high curative effect (especially for chloasma) and no irritation to skin.

The invention discloses an anti-spot beautifying composition comprising the raw materials of skin whitening and moisturizing components of: golden thread, ethanol, lightyellow sophora root, rhubarb, cape jasmine, ligusticum, Szechwan lovage rhizome, largehead atractylodes rhizome, redroot gromwell, ginseng, common bletilla tuber, and the like. A preparation method of the composition comprises the steps that: the materials are sieved and placed in a soaking tank; the materials are mixed with ethanol, and the mixture is stirred; heating and continuous soaking are carried out; the obtained material is filtered; the filtrate is subjected to heating and reflux extraction, and an obtained filtrate is preserved for later use; ligusticum and Szechwan lovage rhizome are soaked by using water, and volatile oil is collected by distillation; the volatile oil is preserved for later use; and the filtrate, the volatile oil, auxiliary materials, arbutin, panthenol, and water are blended, such that a finished product is obtained. The composition provided by the invention causes no irritation to skins, and assists in improving skin capillary permeability and promoting skin blood circulation. The composition has a substantial inhibiting effect against intracellular tyrosinase activity, and assists in substantially reducing intracellular melanin content. With the composition, epidermal cell regeneration capacity development can be accelerated, and skin aging can be retarded. For malar rash, chloasma, dark spots, acne scars, and the like, functions of whitening and spot removing can be achieved rapidly.

The invention discloses a whey protein antihypertensive peptide prepared by utilizing a continuous enzyme membrane reactor and a special device thereof. The continuous enzyme membrane reactor provided by the invention comprises a reactive tank (4), an ultrafiltration membrane assembly (5), a circulating system (7), a collecting tank (9) and a feed tank (6), wherein the reactive tank (4) is connected with the ultrafiltration membrane assembly (5) through the circulating system (7), the feed tank (6) is connected with the reactive tank (4) through a pipeline, and a peristaltic pump (10) is arranged on the pipeline. After whey protein is preprocessed through dissolution, hydration and the like, the antihypertensive peptide is prepared in the continuous enzyme membrane reactor by adopting thetechnologies of proteolysis and membrane separation and coupling. The enzyme membrane reactor shows excellent stability in the operating process, and the ultrafiltration amount thereof always keeps more than 90 percent after the enzyme membrane reactor continuously works for 12 hours. The protein recovery rate reaches more than 78 percent, and the highest suppression ratio of an ACE can reach 90.11 percent.

The invention relates to the technical field of pharmaceutical materials, provides a method for synthesizing a chitosan oligosaccharide / indometacin graft and aims to solve the problems that many chemical antitumor drugs for clinical use are low in selectivity and are difficultly dissolved in water at present. Chitosan oligosaccharide of different molecular weights and indometacin with different grafting rates are selected, so that controlled / slow release of drugs can be realized. Meanwhile, the invention also provides application of the chitosan oligosaccharide / indometacin graft on a slightly soluble drug targeting vector, namely an alkaline adriamycin-loaded chitosan oligosaccharide / indometacin microparticle drug delivery system is provided. The drug delivery system has the characteristics of high drug loading capacity and encapsulation rate.

The invention relates to technical field of medicines, and provides a lycopene compound preparation for assisting in treating prostatic cancer and application thereof. The preparation is prepared fromthe following components in parts by weight: 1 to 20 parts of lycopene, 1 to 20 parts of phytosterol or phytosterol ester, 0.1 to 10 parts of selenium-containing compound and 0.1 to 10 parts of zinc-containing compound. The lycopene compound preparation has the effect of restraining tumor cells, can restrain the growth of prostate fibroblasts, restrain the propagation of tumor and vascular endothelial cells and regulate prostate immune cells, and has a propagating effect on intraprostatic immune cell T subgroups. The preparation can regulate the tumor microenvironment, and has the effect of assisting in treating prostate cancer.

The invention discloses a strain of bacillus amyloliquefaciens with an inhibiting effect on fusarium oxysporum and application of the bacillus amyloliquefaciens. The fusarium oxysporum (FON) is pathogenic bacteria of watermelon fusarium wilt, and biological control is a crucial method for controlling the watermelon fusarium wilt. A bacterial strain for inhibiting the FON is screened from wheat rhizosphere, and the bacterial strain is Bacillus amyloliquefaciens LZN01 through authentication. Experimental results show that the antibacterial rate of the Bacillus amyloliquefaciens LZN01 to the FONis 57.07%, and the spore germination inhibition ratio of the Bacillus amyloliquefaciens LZN01 to the FON is 86.21%. Under the conditions that the temperature is 20-60 DEG C and the pH value is 4-9, the antibacterial effect of a fermented supernatant fluid of the Bacillus amyloliquefaciens LZN01 is stable, and antibacterial substances of the supernatant fluid contain Myriocin, Sphingofungin E, Sphingofungin F, Sphingofungin C and Gabapentin. Therefore, the Bacillus amyloliquefaciens LZN01 has a better inhibiting ability to the FON, the antibacterial effect is stable, and the development and application value is larger in biological control of the watermelon fusarium wilt.

The invention provides a litchi rind total-phenol extract mainly comprising polymer polyphenol and an application of the extract, and belongs to the field of natural-occurring substance extraction. Apreparation method of the litchi rind total-phenol extract includes the steps: soaking litchi rinds in ethanol aqueous solution with the volume concentration of 80% at the temperature of 23-27 DEG C,and performing solid-liquid separation on acquired soak solution to obtain liquid medicines; purifying the liquid medicines by a column chromatography, adsorbing extracted polar active substances on achromatographic column, eluting the polar active substances by the aid of ethanol aqueous solution with the volume concentration of 60%, enabling parts of polar active substances to be eluted, and concentrating and spray-drying acquired eluting liquid to prepare the litchi rind total-phenol extract mainly comprising the polymer polyphenol. The litchi rind total-phenol extract mainly comprising the polymer polyphenol has a strong inhibition effect on tyrosinase and is applied to whitening cosmetics or preservation of fruits and vegetables.

The invention relates to the field of medicinal chemistry, and specifically relates 3-hydroxy-3-[2,3-dihydroquinoline-4-keto-3-yl]indole-2-ketone compounds (I) and pharmaceutically acceptable salts thereof or pharmaceutically acceptable solvent mixtures thereof, a preparation method thereof, and uses of the compounds in preparing medicaments for preventing or treating diseases related to abnormal cell proliferation, morphologic change and the like, in particular medicaments for preventing or treating tumor growth and transfer.

The invention relates to application of a natural monotepene compound sabinene in preparing a herbicide. As is shown through research tests, when the compound is applied with the low concentration of5 micrometers / milliliter, monocotyledons setaria viridis can be killed, and the compound has an obvious inhibition effect on dicotyledons amaranthus retroflexus and alfalfa. The compound contains plant volatile oil components and has fragrance, herbicidal activity and a certain pest repelling effect; the compound is prepared to different concentrations, and separately used or mixed with other pesticides for use before the seedling stage or in the seedling stage, can be naturally degraded, does not pollute the environment, can be used as a herbicide, and has huge potential commercial value.

The invention discloses a p-aminosalicylic acid fluoroquinolone derivative and an intermediate, a preparation method and application thereof, and belongs to the technical field of drug synthesis. Thestructural formula of the p-aminosalicylic acid fluoroquinolone derivative is shown in the specification. In-vitro activity determination results show that part of fluoroquinolone aminosalicylate derivatives (compounds for short) and intermediates have inhibition effects on mycobacterium smegmatis; the compounds and intermediates have good inhibition activity on common pathogenic bacteria as a whole; most compounds and intermediates have better antibacterial activity on pichia pastoris as a whole; part of the compounds have good inhibitory activity on citrus canker pathogens. The p-aminosalicylic acid fluoroquinolone derivative and the intermediate thereof have potential application prospects in the fields of tuberculosis resistance, bacteria resistance, fungus resistance and citrus pathogen resistance.

The invention belongs to the technical field of antineoplastic medicines and provides thieno pyridinone derivative with the structure of the general formula I and salt thereof which are acceptable in pharmacy, wherein n, R1 and R2 are defined in the specification. The invention also relates to a preparation method of the compound, and discloses pharmaceutical composites using the compound or the salt thereof which are acceptable in pharmacy as active ingredient and the applications of the pharmaceutical composites used as the antineoplastic medicines.

The present invention provides a novel 4'-demethyl-4'-O-substituted-1-deoxypodophyllotoxin derivative, a geometric isomer thereof, a process for the preparation thereof, and an anticancer composition comprising the same.

The invention discloses a novel microbial organic fertilizer for preventing and treating perennial root dwarf disease of Saccharum officinarum. The novel microbial organic fertilizer is prepared through the following steps: mixing animal wastes and straw powder, inoculating well-composted mixed bacteria to the mixture, and carrying out compost fermentation, so as to obtain a well-composted material; carrying out amplification culture on bacillus thuringiensis so as to obtain a culture solution for pathogen inhibiting bacteria for perennial root dwarf disease of Saccharum officinarum; carrying out amplification culture on streptomyces globisporus and bacillus megaterium, and carrying out proportioning mixing, so as to obtain an effect promoting bacterium mixed solution; proportionally mixing bamboo charcoal, diatomite and zeolite powder, so as to obtain a soil amendment; and uniformly mixing the well-composted material, the culture solution for the pathogen inhibiting bacteria for the perennial root dwarf disease of the Saccharum officinarum, the effect promoting bacterium mixed solution and the soil amendment proportionally, and carrying out drying, crushing, sieving and granulating, thereby obtaining the microbial organic fertilizer. The microbial organic fertilizer provided by the invention is high in fertility, can be used for truly effectively inhibiting the incidence of the perennial root dwarf disease of the Saccharum officinarum and can also be used for amending soil, improving the activity of the soil, increasing the yield of the Saccharum officinarum and shortening the ripening period of the Saccharum officinarum, thereby having very high economic and social benefits.

The invention belongs to the technical field of medicines for resisting malignant tumors and discloses an oleanolic acid derivative with a structure shown as formula I, wherein R1 stands for a hydrogen; C1-C4 stands for a straight-chain or a branch-chain alkyl; R2 is an ethyl which is substituted by a halogen, a hydroxyl, a C1-C4 straight-chain or a branch-chain alkyl or a C1-C4 straight-chain or a branch-chain alkoxy. Furthermore, the invention relates to a method for preparing the compound, as well as pharmaceutical compositions taking the compound as an active and effective ingredient and applications of the pharmaceutical compositions as medicines for resisting the malignant tumors.

The invention discloses a functional milk vinegar health drink made of cassia seed and other Chinese herbal medicines and milk. It is not only a health vinegar drink with milk flavor, but also a milk product with acetic acid taste, which can satisfy people's desire for beverage flavor and health care effect. , nutrition and other multi-level needs. The invention adopts a three-stage fermentation process of alcohol fermentation, acetic acid fermentation and lactic acid fermentation. The Chinese herbal medicine adopts a two-stage extraction process of first leaching and then synchronous microbial fermentation extraction with the three-stage fermentation. The alcohol fermentation adopts the coexistence fermentation process of solid state and liquid state fermentation . The product is reddish-brown in color, sweet and sour, soft, cool and smooth, with a mellow taste, clear and bright juice, and no impurities; it not only retains the compound aroma of cassia seeds and milk, but also has the sourness and esters and other flavor substances produced by microbial fermentation. It has the effects of promoting body fluid to quench thirst, enhancing immunity, and anti-fatigue. It has the advantages of high extraction rate of active ingredients of Chinese herbal medicine, good flavor, short production cycle, low labor intensity, and good product hygiene.

The invention, belonging to the technical field of anti-malignant tumor medicines, provides a thienopyridone derivative having the structure shown as formula I and pharmaceutically acceptable salts thereof, wherein R1 and R2 are defined as specification. The invention further relates a preparation method of the compound, and simultaneously discloses pharmaceutical compositions with the compound or pharmaceutically acceptable salts thereof as effective active ingredient as well as uses of the pharmaceutical compositions as anti-malignant tumor medicines,.

A spot-removing ointment is prepared from 13 Chinese medicinal materials including notoginseng, apricot kernel, peach kernel, Chinese angelica root, coix seed, etc. through extracting volatile oil from part of them for ready use, recovering the alcohol filtrate from other part of them for ready use, mixing the rest ingredients with the decoction dregs after extracting volatile oil, decocting for ready use, and adding the above-mentioned extracted substances to the extract matrix. Its advantages are high curative effect (especially for chloasma), and no irritation to skin.

The invention relates to an arginase inhibitor as well as a pharmaceutical composition and application thereof. The arginase inhibitor provided by the invention is selected from any one or more compounds of vanillic acid, eriodictyol, salidroside, roseldine, rhodiolaromone, p-coumaric acid and ethyl gallate, or pharmaceutically acceptable salts, stereoisomers, tautomers, isotopes or prodrugs of the compounds, or pharmaceutically acceptable salts, stereoisomers, tautomers, isotopes or prodrugs of the compounds, or pharmaceutically acceptable salts, stereoisomers, tautomers, isotopes or prodrugs of the compounds. The arginase I, the arginase II and pharmaceutically acceptable auxiliary materials can form a pharmaceutical composition, and the arginase I, the arginase II and pharmaceutically acceptable auxiliary materials can be used for preparing drugs for treating or preventing diseases, symptoms or symptoms related to expression or activity of the arginase I, the arginase II or a combination of the arginase I and the arginase II in individuals. The arginase inhibitor disclosed by the invention has a relatively high inhibition rate on arginase I and arginase II, and is used as a potent and selective arginase inhibitor to reverse immunosuppression and reactivate the anti-cancer immunity of a patient through a single medicament or in a manner of being combined with a therapy for reversing other immunosuppression mechanisms.

The invention discloses a preparation method of a biodegradable wound dressing, comprising the following steps: step 1, adding 30-40 part of chitosan with a mass concentration of 1-3% hydrochloric acid to carry out acidification for 1-2 hours, and then washed with water for 2-3 time until the washing solution is neutral, then adding into deionized water for ultrasonic dispersion, and dispersing 20-30 min, and then adding glacial acetic acid to adjust the pH to 4.0-5.0. The rare earth salt of the invention has good anti-inflammatory and bactericidal effect, and has good antibacterial activity,as the chitosan is modify, for enhancing the antimicrobial activity of chitosan, the introduction of nano-montmorillonite into modified bacterial cellulose can enhance the antimicrobial activity of bacterial cellulose itself, and the coordination of rare earth salts with nano-montmorillonite in the crosslinking process of chitosan and bacterial cellulose can further combine in the crosslinking network structure to improve the stability of the material system.

The invention provides Ocotillol type esterification derivatives represented by formula (I-R) or formula (I-S) and Ocotillol type esterified derivatives represented by formula (II-R) or formula (II-S). The compounds represented by the formula (II-R) or the formula (II-S) are prepared from the compounds represented by the formula (I-R) or the formula (I-S) through deprotection. The invention further provides a preparation method of the compounds represented by the formula (I-R), the formula (I-S), the formula (II-R) or the formula (II-S) and pharmaceutically acceptable salts of the compounds, and application of the compounds in preparation of anti-inflammatory drugs or anti-inflammatory drug compositions. The Ocotillol type esterified derivatives provided by the invention are obviously superior to the existing clinical drug hydrocortisone sodium succinate in the aspect of inhibiting the generation of an inflammatory signal molecule NO. Moreover, the Ocotillol type esterification derivatives are high in biological friendliness and good in drug safety, show a longer half-life period in in-vitro metabolic stability evaluation, and can improve the safety and stability of the patent drug.

The invention discloses a functional milk vinegar health drink taking Chinese herbal medicines such as semen cassiae and milk as raw materials. The functional milk vinegar health drink is a health vinegar drink with milk taste and is a dairy product with acetic acid taste, so that the multi-level requirements on drink flavor, health care effect and nutrition of people can be met. With the adoption of three-section fermentation process such as alcoholic fermentation, acetic fermentation and lactic acid fermentation, the Chinese herbal medicines are leached and subjected to a two-section extraction process for three-section fermented synchronous microbial fermentation and extraction, and the alcoholic fermentation adopts solid-state and liquid-state fermentation coexistence fermentation process. The product is red brown in color, sour and sweet in taste, soft, cool and smooth, mellow in taste, clear and transparent in juice and impurity-free. The composite aroma of the semen cassiae and milk is remained, and the health drink has sour feel and flavor substances such as esters generated by microbial fermentation, has the effects of helping produce saliva and slaking thirst, enhancing the immunity and resisting fatigue, and has the advantages that the Chinese herbal medicine active ingredients are high in leaching rate and the health drink is good in flavor, short in production cycle, low in labor intensity and good in sanitation.

The invention relates to the technical field of food microorganisms, and particularly discloses Lactobacillus reuteri ZJUIDS09, the preservation number of which is CGMCC NO. 22843. The invention also provides application of the Lactobacillus reuteri ZJUIDS09 in preparing a product with a function of reducing blood pressure.

The invention discloses an anti-spot beautifying composition comprising the raw materials of skin whitening and moisturizing components of: golden thread, ethanol, lightyellow sophora root, rhubarb, cape jasmine, ligusticum, Szechwan lovage rhizome, largehead atractylodes rhizome, redroot gromwell, ginseng, common bletilla tuber, and the like. A preparation method of the composition comprises the steps that: the materials are sieved and placed in a soaking tank; the materials are mixed with ethanol, and the mixture is stirred; heating and continuous soaking are carried out; the obtained material is filtered; the filtrate is subjected to heating and reflux extraction, and an obtained filtrate is preserved for later use; ligusticum and Szechwan lovage rhizome are soaked by using water, and volatile oil is collected by distillation; the volatile oil is preserved for later use; and the filtrate, the volatile oil, auxiliary materials, arbutin, panthenol, and water are blended, such that a finished product is obtained. The composition provided by the invention causes no irritation to skins, and assists in improving skin capillary permeability and promoting skin blood circulation. The composition has a substantial inhibiting effect against intracellular tyrosinase activity, and assists in substantially reducing intracellular melanin content. With the composition, epidermal cell regeneration capacity development can be accelerated, and skin aging can be retarded. For malar rash, chloasma, dark spots, acne scars, and the like, functions of whitening and spot removing can be achieved rapidly.