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Preparation method of biodegradable wound dressing

A wound dressing and biodegradable technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of moisture permeability, porosity decrease, and affecting the overall performance of materials, etc., achieve good anti-inflammatory and bactericidal effects, and strong bacterial inhibition rate , good antibacterial activity

Inactive Publication Date: 2019-01-25
HEFEI HUAGAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is based on a degradable natural polymer, and antibacterial drugs and halloysite nanotubes loaded with antibacterial drugs are added to prepare elastomeric biofilms with different biological activities through hot melt blending. The halloysite added to this material Although stone nanotubes can improve the therapeutic effect of drugs, the addition of halloysite nanotubes will lead to a decrease in moisture permeability and porosity, which in turn will affect the overall performance of the material

Method used

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  • Preparation method of biodegradable wound dressing

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Effect test

Embodiment 1

[0023] A kind of preparation method of biodegradable wound dressing of the present embodiment, comprises the following steps:

[0024] Step 1: Acidify 30 parts of chitosan with 1% hydrochloric acid for 1 h, then wash with water twice until the washing solution is neutral, then add it into deionized water for ultrasonic dispersion, disperse for 20 min, and then add ice Adjust the pH to 4.0 with acetic acid, then add rare earth salts with 15% of the total mass of chitosan, and stir for 2 hours at 65°C. After the reaction is completed, wash with water, centrifuge, and dry to obtain the product to be prepared for use;

[0025] Step 2, mix the standby product and modified bacterial cellulose in step 1 according to a weight ratio of 1:1.2, then add a composite cross-linking agent of 4% of the total mass of the standby product and modified bacterial cellulose, and then add the composite cross-linking agent MES buffer solution 7 times the total mass of the agent, react for 1 hour, the...

Embodiment 2

[0033] A kind of preparation method of biodegradable wound dressing of the present embodiment, comprises the following steps:

[0034] Step 1: Acidify 40 parts of chitosan with 3% hydrochloric acid for 2 hours, then wash with water 3 times until the washing liquid is neutral, then add it into deionized water for ultrasonic dispersion, disperse for 30 minutes, and then add ice Adjust the pH to 5.0 with acetic acid, then add rare earth salts with 25% of the total mass of chitosan, and stir for 5 hours at 75°C. After the reaction is completed, wash with water, centrifuge, and dry to obtain the product to be prepared for use;

[0035] Step 2, mix the standby product and modified bacterial cellulose in step 1 according to a weight ratio of 1:1.8, then add a composite cross-linking agent of 10% of the total mass of the standby product and modified bacterial cellulose, and then add the composite cross-linking agent MES buffer solution 9 times the total mass of the agent, react for 2 ...

Embodiment 3

[0043] A kind of preparation method of biodegradable wound dressing of the present embodiment, comprises the following steps:

[0044] Step 1: Acidify 35 parts of chitosan with hydrochloric acid with a mass concentration of 2% for 1.5 hours, then wash with water for 3 times until the washing solution is neutral, then add it to deionized water for ultrasonic dispersion, disperse for 25 minutes, and then add Adjust the pH to 4.5 with glacial acetic acid, then add rare earth salts with 20% of the total mass of chitosan, and stir for 3.5 hours at 70°C. After the reaction is completed, wash with water, centrifuge, and dry to obtain the product to be prepared for use;

[0045] Step 2, mix the standby product and modified bacterial cellulose in step 1 according to a weight ratio of 1:1.5, then add a composite cross-linking agent of 7% of the total mass of the standby product and modified bacterial cellulose, and then add the composite cross-linking agent MES buffer with 8 times the t...

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Abstract

The invention discloses a preparation method of a biodegradable wound dressing, comprising the following steps: step 1, adding 30-40 part of chitosan with a mass concentration of 1-3% hydrochloric acid to carry out acidification for 1-2 hours, and then washed with water for 2-3 time until the washing solution is neutral, then adding into deionized water for ultrasonic dispersion, and dispersing 20-30 min, and then adding glacial acetic acid to adjust the pH to 4.0-5.0. The rare earth salt of the invention has good anti-inflammatory and bactericidal effect, and has good antibacterial activity,as the chitosan is modify, for enhancing the antimicrobial activity of chitosan, the introduction of nano-montmorillonite into modified bacterial cellulose can enhance the antimicrobial activity of bacterial cellulose itself, and the coordination of rare earth salts with nano-montmorillonite in the crosslinking process of chitosan and bacterial cellulose can further combine in the crosslinking network structure to improve the stability of the material system.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a preparation method of a biodegradable wound dressing. Background technique [0002] The skin is an important part of the human body. When the skin is damaged, it will cause different degrees of systemic reactions. Therefore, it has always been people's pursuit to seek efficient wound treatment methods. Wound healing is a complex biological process, including hemostasis, inflammation, Cell proliferation, scar formation and regeneration of epidermis and other tissues. Dressing is an important means of treating skin wounds. Traditional wound dressings use gauze and artificial synthetic fibers. This type of wound dressing is easy to make and low in cost, but it is easily infected by bacteria. Bio-based dressings are biocompatible and have no side effects, and can provide environmental protection to avoid bacterial invasion and infection. Compared with traditional wound dres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44A61L15/46
CPCA61L15/28A61L15/44A61L15/46A61L2300/102A61L2300/404A61L2300/604C08L5/08C08L1/02
Inventor 张安育
Owner HEFEI HUAGAI BIOTECH CO LTD
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