Method for improving bioactivity of exendin fusion protein

A fusion protein and insulin-stimulating technology, which is applied in the field of biomedicine, can solve problems such as prolongation, and achieve the effect of prolonging half-life, good application prospects, and high biological activity
CN101875700AActive Publication Date: 2010-11-03无锡和邦生物科技有限公司 +1
3 Cites 9 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
无锡和邦生物科技有限公司
Publication Date
2010-11-03

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a method for improving the bioactivity of an exendin fusion protein, which belongs to the technical field of biopharmaceuticals. In the method, an Exendin-4 and GLP-1 are connected in series first and then are connected with human serum albumin HSA or human immunoglobulin Fc to form the fusion protein, so as to increase the bioactivity of the exendin fusion protein. The fusion protein is expressed as: (Exendin-4-GLP-1)n-HSA, (GLP-1-Exendin-4)n-HSA, (Exendin-4-GLP-1)n-Fc or (GLP-1-Exendin-1)n-Fc, wherein the value of n ranges from 1 to 5. The fusion protein prepared by the method has higher bioactivity than a fusion protein Exendin-4-HSA or a GLP-1-HSA protein. The fusion protein of the invention can be used for preparing medicaments for treating non-insulin-dependent diabetes, various symptoms of the non-insulin-dependent diabetes and obesity.
Need to check novelty before this filing date? Find Prior Art

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More