Application of silicone oil in preparing allergen retarder

A technology of allergens and blockers, applied in the field of silicone oil, can solve problems such as no patent reports, achieve good economic and social benefits, reduce occurrence and severity, and reduce exposure

Active Publication Date: 2010-12-08
张罗
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no research reports on the use of its adhesive properties to prevent and alleviate allergic rhinitis, and no foreign patent reports on this aspect

Method used

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  • Application of silicone oil in preparing allergen retarder
  • Application of silicone oil in preparing allergen retarder
  • Application of silicone oil in preparing allergen retarder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1. The silicone oil in the present embodiment is the compound with following structure:

[0064]

[0065] n=300-500, the relative molecular mass is about 20000-40000, and the average viscosity is about 600-1000cSt;

[0066] Select 10 patients with a history of seasonal allergic rhinitis for several years, and use this product one to two weeks before the onset of seasonal allergic rhinitis until one week after the onset of the onset.

[0067] How to use: Apply 0.2cm of this product every day 3 Apply it to the nasal vestibule, check before using this product and one week after the onset period, and compare according to the following two aspects:

[0068] VAS score: visual analog scale (visual analogue scale, VAS) score and standardized questionnaire survey, nasal itching, left nasal congestion, right nasal congestion, sneezing, clear water nasal discharge were scored separately, on a 10cm visual analog scale (visual analog scale) , VAS) self-assessment of ...

Embodiment 2

[0073] Embodiment 2. The silicone oil in the present embodiment is the compound with following structure:

[0074]

[0075] n=1000-1300, the relative molecular mass is about 60000-100000, and the average viscosity is about 10000-40000cSt.

[0076] Select 10 patients who are in the attack period of seasonal allergic rhinitis and have not used any drugs or anti-allergic treatments within two weeks, and this product was used.

[0077] How to use: Apply 0.2cm of this product every day 3 Apply it to the nasal vestibule, and perform nasal symptom VAS score and nasal acoustic reflex examination before and after using this product for 2 weeks.

[0078] The data of the experimental results are similar to the data in Table 3 and Table 4 above, so they are omitted here.

[0079] Seasonal allergic rhinitis is caused by pollen and other allergens with seasonal appearance characteristics. During the attack period of seasonal allergic rhinitis patients, apply this product on the nasal v...

Embodiment 3

[0082] Embodiment 3. the silicone oil in the present embodiment is the compound with following structure:

[0083]

[0084] n=3000-5000, relative molecular mass 200000-400000, average viscosity 300000-1000000cSt;

[0085] 1. Materials and Methods

[0086] Select 10 patients with perennial allergic rhinitis who are completely voluntary and have not used any drugs or anti-allergic treatments within two weeks, and applied this product.

[0087] How to use: Apply 0.2cm of this product every day 3 (Soybean size) smeared on the nasal vestibule, before using this product and after using this product for 2 weeks, perform nasal symptom VAS score and nasal acoustic reflex examination.

[0088] The data of the experimental results are similar to the data in Table 5 and Table 6 above, so they are omitted here.

[0089] Perennial allergic rhinitis is caused by a variety of allergens. Applying this product on the nasal vestibule can effectively adhere to inhaled allergens and reduce t...

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PUM

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Abstract

The invention relates to an application of silicone oil in preparing an allergen retarder. Silicone oil can be smeared on the inner wall of the nasal cavity to stick allergens in the air to inhibit the allergic reaction, thereby performing the functions of preventing and relieving the allergic rhinitis. The inventor discovers that when the silicone oil is used before the stage of attack of the seasonal allergic rhinitis, the attack of the seasonal allergic rhinitis can be effectively prevented; after the attack of the seasonal allergic rhinitis, a patient continuously uses the silicone oil for two weeks, and then, the attack degree of the seasonal allergic rhinitis can be effectively relieved; and for perennial allergic rhinitis, the patient continuously uses the silicone oil for two weeks, and then, the attack degree of the perennial allergic rhinitis can also be effectively relieved.

Description

technical field [0001] The invention relates to a new medical application of silicone oil. Silicone oil (English Silicones) can significantly prevent and reduce the occurrence of allergic rhinitis by sticking to inhaled allergens. Background technique [0002] Allergic rhinitis (Allergic Rhinitis, AR) is a nasal inflammatory disease triggered by allergens and mediated by IgE, including seasonal allergic rhinitis and perennial allergic rhinitis. The global prevalence of allergic rhinitis has shown a clear upward trend in the past 30 years. It is of great clinical significance to develop allergen blockers that can prevent and control the occurrence and onset of allergic rhinitis. One of the most important external causes of allergic rhinitis is allergens. Allergens are water-soluble proteins or glycoproteins that can combine with IgE and have sensitizing or potential sensitizing activities. The molecular weight is 5-70Kda. Animal fur, fungus and food, etc. Allergens that ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/80A61P37/08A61P11/02A23L1/30A23L33/10
Inventor 张罗周芸
Owner 张罗
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