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Preparation method of kalopanax septemlobus leaf total effective part and medical application thereof

A technology of effective parts and catalpa leaves is applied in the application field of prevention and treatment of rheumatic bone pain diseases, can solve the problems that the extraction and purification of effective parts and the application of medicines are rarely involved, etc., and achieves good product stability and uniformity. The effect of international market competitiveness and ease of industrial production

Inactive Publication Date: 2010-12-29
王隶书
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although scholars at home and abroad have conducted in-depth studies on the chemical constituents and pharmacological activities of the plants of the genus Erythronia, but little has been done on the extraction and purification of their effective parts and their medicinal applications.

Method used

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  • Preparation method of kalopanax septemlobus leaf total effective part and medical application thereof
  • Preparation method of kalopanax septemlobus leaf total effective part and medical application thereof
  • Preparation method of kalopanax septemlobus leaf total effective part and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 3kg of Cinnamon chinensis leaves, crush them as appropriate, extract twice with 30kg of 70% ethanol under reflux, each time for 1.5 hours, filter, combine the filtrate, recover the ethanol, concentrate to a volume of 1L, add water to 3L, centrifuge, and take the supernatant Pass the solution through a D101 macroporous adsorption resin column with a column bed volume of 1L, wash with 8L of water, discard the water, and then elute with 7.5L of 70% ethanol, collect the eluate, recover the ethanol, concentrate, refine, and dry to obtain The total effective parts of the leaves of Cinnamon chinensis. The content of total saponin in the total effective parts of the leaves of Erythrina chinensis is 62%.

Embodiment 2

[0019] Take 3kg of Cinnamon chinensis leaves, crush them as appropriate, extract twice with 12kg of 95% ethanol under reflux, each time for 1.5 hours, filter, combine the filtrate, recover the ethanol, concentrate to a volume of 1L, add water to 3L, centrifuge, and take the supernatant The solution was passed through an AB8 macroporous adsorption resin column with a column bed volume of 1 L, washed with 5 L of water, discarded the water, and then eluted with 10 L of 95% ethanol, collected the eluate, recovered the ethanol, concentrated, refined, and dried to obtain the thorn The total effective parts of catalpa leaf. The content of total saponin in the total effective parts of the leaves of Erythrina chinensis is 71%.

Embodiment 3

[0021] Take 3 kg of leaves of Catalpa chinensis, crush them as appropriate, extract twice with 24 kg of water for 1.5 hours each time, filter, combine the filtrates, concentrate to a volume of 1 L, and pass through NKA-9 macroporous adsorption resin column with a column bed volume of 1 L. First wash with 10L of water, discard the water, then elute with 5L of 50% ethanol, collect the eluent, recover the ethanol, concentrate, refine, and dry to obtain the total effective parts of the leaves of Echinacea. The content of total saponin in the total effective parts of the leaves of Erythrina chinensis is 53%.

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Abstract

The invention provides a preparation method of a kalopanax septemlobus leaf total effective part and medical application thereof, belonging to the field of traditional Chinese medicines. The preparation method of the kalopanax septemlobus leaf total effective part comprises the following steps of: carrying out reflux extraction by taking kalopanax septemlobus leaves or velamina as raw materials and using a 0%-95% aqueous ethanol solution; properly processing a concentrated extracting solution, and sequentially eluting by using water and 50%-95% ethanol through a macroporous adsorbent resin column; collecting an ethanol eluent, concentrating, refining, and drying so as to obtain the kalopanax septemlobus leaf total effective part, wherein total saponin content is more than or equal to 50 percent. In the method, the extraction is carried out by only taking the ethanol and the water as solvents, and the separation and the purification can be carried out by adopting a macroporous resin adsorption technology, and the kalopanax septemlobus leaf total effective part as the finished product has the advantages of high purity, good stability and uniformity of products; and the method of the invention has the advantages of reasonable design, low cost, easy operation, good stability, stricter quality control and easy industrialized production.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a preparation method of the total effective part of the leaves of Chinese catalpa chinensis, a new medicine prepared from the same as a raw material, and an application thereof in preventing and treating rheumatism and bone pain. Background technique [0002] The thorny catalpa is Kalopanax septemlobus (Thunb.) Koidz., a plant of the genus Kalopanax septemlobus (Thunb.) Koidz., which has the effects of expelling wind, dehumidification, dredging collaterals, relieving pain, and killing insects. It is clinically used to treat rheumatoid arthritis, waist and knee pain, and is used externally Bruises. It has been reported that the main active ingredient of Echinopsis is saponins, and its biological activities are mainly manifested in anti-tumor, anti-inflammatory, analgesic, anti-rheumatoid, anti-fungal and anti-diabetic. At present, 45 kinds of pentacyclic triterpenoid sa...

Claims

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Application Information

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IPC IPC(8): A61K36/25A61P29/00A61P19/08A61K127/00
Inventor 王隶书刘永宏程东岩邸琳
Owner 王隶书
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