Plant soft capsule material and preparation method thereof

A soft capsule, plant-based technology, applied in the field of plant-based soft capsule material and its preparation, can solve the problems of lack, prolonged dissolution time, changes in effective drug components, etc., to ensure stability, avoid insufficient toughness, and improve performance. Effect

A soft capsule, plant-based technology, applied in the field of plant-based soft capsule material and its preparation, can solve the problems of lack, prolonged dissolution time, changes in effective drug components, etc., to ensure stability, avoid insufficient toughness, and improve performance. Effect

CN101961495BInactive Publication Date: 2012-10-31北京盈康宝科技发展有限公司 +1
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  • Plant soft capsule material and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] First, add 9988g of water into the container, weigh 1g of linseed gum, add it into the water, and stir for 10-20 minutes until the linseed gum and water are completely dissolved. Then, add thickener pullulan 2g, film-forming agent carboxymethylcellulose sodium 2g and binder maltose 2g respectively, stir constantly, wait for linseed gum and pullulan, carboxymethylcellulose sodium, Stir the maltose evenly and let it stand for 1 hour to defoam. Next, 5 g of plasticizer glycerin was added, heated to 40° C., and stirred. After stirring evenly, the temperature was kept, and after defoaming at rest for 5 hours, a glue solution was obtained. Finally, the solution was pressed into a film with a thickness of 3 mm, and placed in an environment of 30° C. for 10 hours to dry to obtain the soft capsule material.

Embodiment 2

[0038] First, add 40g of water to the container, weigh 20g of linseed gum, add it to the water, wait until the linseed gum and water are completely dissolved, and let stand for 2 hours to defoam. Then, 10 g of thickener guar gum and 10 g of film-forming agent gum arabic were added respectively, and stirred continuously. After the linseed gum, guar gum, and gum arabic were completely stirred evenly, they were allowed to stand for 1 hour for defoaming. Next, 10 g of plasticizer glycerin and 10 g of polyethylene glycol were added and stirred. After stirring evenly, the mixture was heated to 100° C., kept at the temperature, and left to stand for 5 hours to defoam to obtain a glue solution. Finally, the solution was pressed into a film with a thickness of 3 mm, and dried at 40° C. for 10 hours to obtain the soft capsule material.

Embodiment 3

[0040] First, add 4900g of water to the container, weigh 5g of linseed gum, add it to the water, wait until the linseed gum and water are completely dissolved, and let stand for 2 hours to defoam. Then, add 10g of thickener guar gum, 10g of film-forming agent gum arabic, and 25g of binder starch respectively, and keep stirring until the linseed gum, guar gum, gum arabic, and starch are completely stirred evenly and then stand for 1h Perform defoaming. Next, add 30 g of plasticizer glycerin and 20 g of polyethylene glycol, stir, and after stirring evenly, heat to 100° C., keep the temperature, and stand for 5 hours to defoam to obtain a glue solution. Finally, the solution was pressed into a film with a thickness of 3 mm, and dried at 40° C. for 10 hours to obtain the soft capsule material.

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Abstract

The invention provides a plant soft capsule material. The capsule material is at least prepared from the following raw materials in percentage by weight: 0.01 to 20 percent of flaxseed gum, 0.02 to 20 percent of thickening agent, 0.02 to 20 percent of film forming agent, 0.05 to 20 percent of plasticizer and the balance of water. The invention also provides a method for preparing the plant soft capsule material. A soft capsule prepared from the plant soft capsule material has the advantages of high medicament stability, high elasticity, high toughness, long shelf life and the like, is not limited by religion and taboo and can be popularized and applied all over the world.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a vegetable soft capsule material and a preparation method thereof. Background technique [0002] At present, gelatin is generally used as the main raw material for the production of soft capsule shells. It is mainly derived from animal skin, tendons, bones, etc., and is a protein that is partially hydrolyzed from the collagen in the connective tissue or epidermal tissue of animals; the reason for choosing Gelatin is used as the capsule material because it has good thermal reversibility and improves the disintegration rate and dissolution rate of the drug to a certain extent compared with traditional capsules. However, through long-term clinical application, it has been found that the soft capsule material made of gelatin as the main raw material still has the following problems: [0003] First, because gelatin is a proteinaceous substance, it contains a large amount of amino gr...

Claims

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Application Information

Patent Timeline
31 Oct 2012
Publication
CN101961495B
IPC
A61K47/36; A61K47/38; A61K9/48
Inventors
周洋; 路静