Sample preparation system for processing of clinical specimens
A processing system, microprocessor technology, used in the processing of clinical samples or specimens, to solve problems such as increased time to provide diagnostic results, increased likelihood, and reduced sample or specimen consistency
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example 1
[0044] An exemplary sample preparation system includes an input platform for holding multiple vials. The shape of the import platform is such that a plurality of individual removable segments can be received, wherein vials can be loaded prior to placement of the import rack segments into the processing device. Up to 88 20ml vials containing specimens collected in collection medium or up to 176 10ml vials containing specimens collected in transport medium can be loaded into input racks and placed into the Input on the platform, including transport to the appropriate target board. The sample or specimen medium can be PRESERVCYT or SPECIMEN TRANSPORTMEDIUM. Depending on the amount of specimen, the target plate can be a 96-well microplate or a 96-deep-well filter plate. Typically, samples from 20ml vials can be applied to the deep well filter plate, while samples from 10ml vials are applied to the microwell plate. Neither the input platform nor the input platform rack are requi...
example 2
[0063] In order to increase the throughput of processed samples, the SPS can remove caps during vial transfer from the input platform to the vortex mixer, or during transfer from the vortex mixer to the work platform. Read the barcode and other identification information on the vial during the process. In an exemplary SPS, while the vial is held by the vial handling arm 4 and moved towards the work platform, the vial passes a barcode reader which reads the vial's barcode. Reading the barcode in this manner can be facilitated by orienting the barcode in the input platform rack during loading of the vial by the operator. Markers are positioned on the input platform rack to help orient the vial barcode so that it can be easily read by a barcode reader. If the barcode of the sample vial is not read before the sample vial arrives at the work platform, after the sample vial has been placed in the well of the work platform, the cap manipulator arm 5 will pick up the sample vial and ...
example 3
[0064] In one sample handling operation of an exemplary SPS, there may be a need to further disperse the specimen before removing it from the decapped vial. To aid in this process, several different methods may be required to ensure adequate specimen dispersion and distribution.
[0065] Reagents to aid in the dispersion of specimens may be added to the vial contents. This reagent will ensure that a sufficient amount of sample is resuspended and aliquoted. After the vial is uncapped, a precise amount of dispersion reagent is drawn from the reagent bottle 13, added to the vial, and the vial is recapped. During the addition of the dispersing agent, the sample is hydrodynamically mixed by repeatedly aspirating and draining the suspension. After the hydrodynamic mixing, an aliquot can be removed and transferred to the destination container. If further mixing is required, the recapped vial is placed in the vortex mixer and shaken. The cap of the vial can then be removed and the...
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