Method for establishing chronic obstructive pulmonary disease superposition asthma model

Abstract

The invention belongs to the field of biomedicine, relating to a method for establishing a chronic obstructive pulmonary disease superposition asthma model. By adopting a combined method of Drip endotoxin and smoke in trachea and egg albumin sensitization inspiration, the invention has reliable evaluation on aspects of lung tissue pathology, bronchial reactivity, serum cytokine, hypothalamus-hypophysis-adrenal axis and the like. The result of comparison with the pure chronic obstructive pulmonary disease or asthma model shows that the chronic obstructive pulmonary disease superposition asthma model has the characteristic change of the chronic obstructive pulmonary disease or asthma and weakens or intensifies the charateristic pathologic physiological changes. The invention has the advantages of simple preparation and good reliability and repetitiveness, and meets the disease pathologic physiological characteristics of the chronic obstructive pulmonary disease merger asthma, and can be used for the research of pathogenic mechanisms, prevention and treatment, and the like of the chronic obstructive pulmonary disease merger asthma.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to an experimental model of respiratory diseases, in particular to a method for establishing a chronic obstructive pulmonary disease (COPD) superimposed asthma model Background technique [0002] In clinical medicine, bronchial asthma and chronic obstructive pulmonary disease (COPD) are divided into common diseases of the respiratory system, both of which have the characteristics of airway inflammation, but sometimes the boundary between the two is not very clear, especially in smoking asthma Patients with severe exacerbation of COPD have pathophysiological characteristics of both asthma and COPD, and their pathogenesis and pathophysiology become more complicated, which brings challenges to clinical prevention and treatment. Other studies have shown that asthma and COPD and other airway Inflammatory diseases all have changes in the body's stress system such as the HPA axis, but the conclusio...

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Problems solved by technology

[0002] In clinical medicine, bronchial asthma and chronic obstructive pulmonary disease (COPD) are divided into common diseases of the respiratory system, both of which have the characteristics of airway inflammation, but sometimes the boundary between the two is not very clear, especially in smoking asthma Patients with severe exacerbation of COPD have pathophysiological characteristics of both asthma and COPD, and their pathogenesis and pathophysiology become more complicated, which brings challenges to clinical prevention and treatment. Other studies have shown that airway diseases such as asthma and COPD Inflammatory diseases all have changes in the body's stress system such as the HPA axis, but the conclusions are often inconsistent or contradictory. Therefore, establishing relevant animal models and exploring their pathogenesis is of great significance for the prevention and treatment of clinical COPD combined with asthma

So far, there are no corresponding animal model establishment methods and related research reports at home and abroad.

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