Method for establishing chronic obstructive pulmonary disease superposition asthma model

A technology for chronic obstructive pulmonary disease and asthma, applied in the field of biomedicine, can solve problems such as unclear boundaries, inconsistent conclusions, and self-contradictions

Inactive Publication Date: 2011-03-30
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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Problems solved by technology

[0002] In clinical medicine, bronchial asthma and chronic obstructive pulmonary disease (COPD) are divided into common diseases of the respiratory system, both of which have the characteristics of airway inflammation, but sometimes the boundary between the two is not very clear, especially in smoking asthma Patients with severe exacerbation of COPD have pathophysiological characteristics of both asthma and COPD, and their pathogenesis and pathophysiology become more complicated, which brings challenges to clinical preventio

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  • Method for establishing chronic obstructive pulmonary disease superposition asthma model
  • Method for establishing chronic obstructive pulmonary disease superposition asthma model
  • Method for establishing chronic obstructive pulmonary disease superposition asthma model

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Embodiment 1

[0024] Experimental animals: healthy and clean male BN rats, weighing 180-220 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Company. The animals were kept in the Experimental Animal Center of Fudan University in Shanghai, and the feeding conditions were clean, with fixed light time and free intake of water and food.

[0025] Main reagents and instruments: egg protein (Shanghai Livzon Dongfeng Biotechnology Co., Ltd.); aluminum hydroxide gel (Sigma.Co.); 5, 6, 8 kits, IFN-γ kit, TNF-α kit (Biosource imported packaging); corticosterone kit (R&D company); ACTH radioimmunoassay kit (Institute of Neurobiology, Second Military Medical University) ; SN-695B intelligent radio-immunity gamma measuring instrument (Shanghai Nuclear Research Institute Langrihuan Instrument Factory 1); DL-8R refrigerated centrifuge (Shanghai Centrifugal Machinery Research Institute); FeroTec GradienPCR gene amplification instrument (Hangzhou Dahe Thermomagnetic Electronics Co....

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Abstract

The invention belongs to the field of biomedicine, relating to a method for establishing a chronic obstructive pulmonary disease superposition asthma model. By adopting a combined method of Drip endotoxin and smoke in trachea and egg albumin sensitization inspiration, the invention has reliable evaluation on aspects of lung tissue pathology, bronchial reactivity, serum cytokine, hypothalamus-hypophysis-adrenal axis and the like. The result of comparison with the pure chronic obstructive pulmonary disease or asthma model shows that the chronic obstructive pulmonary disease superposition asthma model has the characteristic change of the chronic obstructive pulmonary disease or asthma and weakens or intensifies the charateristic pathologic physiological changes. The invention has the advantages of simple preparation and good reliability and repetitiveness, and meets the disease pathologic physiological characteristics of the chronic obstructive pulmonary disease merger asthma, and can be used for the research of pathogenic mechanisms, prevention and treatment, and the like of the chronic obstructive pulmonary disease merger asthma.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to an experimental model of respiratory diseases, in particular to a method for establishing a chronic obstructive pulmonary disease (COPD) superimposed asthma model Background technique [0002] In clinical medicine, bronchial asthma and chronic obstructive pulmonary disease (COPD) are divided into common diseases of the respiratory system, both of which have the characteristics of airway inflammation, but sometimes the boundary between the two is not very clear, especially in smoking asthma Patients with severe exacerbation of COPD have pathophysiological characteristics of both asthma and COPD, and their pathogenesis and pathophysiology become more complicated, which brings challenges to clinical prevention and treatment. Other studies have shown that asthma and COPD and other airway Inflammatory diseases all have changes in the body's stress system such as the HPA axis, but the conclusio...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K31/739A61P11/00A61P11/06A61K33/06
Inventor 董竞成崔焱刘宝君吴金峰徐长青曹玉雪蔡萃
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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