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Medicament for treating coronary heart disease and extraction thereof

A coronary heart disease and drug technology, applied in the field of drugs for the treatment of coronary heart disease, can solve the problems of no quality control indicators, backward production technology, slow absorption, etc.

Active Publication Date: 2011-04-27
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are ordinary compound Danshen tablets and capsules on the market, but the production technology of ordinary tablets and capsules is backward, the content of active ingredients is low, and there is no quality control index. It needs to be taken orally and absorbed through the gastrointestinal tract, and absorbed after the first-pass effect in the liver. Into the blood, low bioavailability, slow absorption. It is not suitable for the first aid needs of patients with angina pectoris

Method used

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  • Medicament for treating coronary heart disease and extraction thereof
  • Medicament for treating coronary heart disease and extraction thereof
  • Medicament for treating coronary heart disease and extraction thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Embodiment 1 The preparation of the drug drop pill for the treatment of coronary heart disease, each component is made up of the weight percent of active ingredient of medicine in terms of crude drug: Salvia miltiorrhiza 82.87%, Radix Notoginseng 16.21%, Borneol 0.92%;

[0067] Step 1: Extract 3 times the amount of Danshen with 95% ethanol under reflux for 2 hours, filter; add 2 times the amount of 95% ethanol to the dregs, extract under reflux for 1 hour, filter, concentrate the extract under reduced pressure, and dry to obtain 95% alcohol extraction of Salvia miltiorrhiza thing;

[0068] Step 2, adding Radix Notoginseng to the medicinal residues of Danshen obtained after alcohol extraction in step 1, adding 5 times the amount of 40% ethanol to reflux extraction for 1.5 hr, and filtering; adding 4 times the amount of 50% ethanol to the remaining medicinal residues to reflux extraction for 1 hr, filtering, The extract is concentrated under reduced pressure and dried. Ad...

Embodiment 2

[0071] Embodiment 2 The preparation of the medicine dripping pill for the treatment of coronary heart disease, each component is made up of the weight percentage of active ingredient of medicine in terms of crude drug: Salvia miltiorrhiza 19.8%, Radix Notoginseng 78.2%, Borneol 2%;

[0072] Step 1, 85% ethanol with 2 times the amount of Danshen, reflux extraction once, 1 hour each time, filter, concentrate the extract under reduced pressure, and dry to obtain 85% ethanol extract of Danshen;

[0073] Step 2, adding Radix Notoginseng to the medicinal residues of Danshen obtained after alcohol extraction in step 1, adding 5 times the amount of 40% ethanol to reflux extraction for 1.5 hr, and filtering; adding 4 times the amount of 50% ethanol to the remaining medicinal residues to reflux extraction for 1 hr, filtering, The extract is concentrated under reduced pressure and dried. Add water to dissolve until the sugar content is 48-52%, add ethanol to make the alcohol content reach...

Embodiment 3

[0076] Embodiment 3 The preparation of the drug drop pill for the treatment of coronary heart disease, each component is composed of the weight percentage of active ingredient of medicine in terms of crude drug: Salvia miltiorrhiza 97%, Panax notoginseng 2%, Borneol 1%;

[0077] Step 1, 5 times the amount of Danshen root in 95% ethanol, reflux extraction 3 times, each time for 3 hours, filter, the extract was concentrated under reduced pressure and dried to obtain 95% alcohol extract of Danshen;

[0078] Step 2, the medicinal residues of Danshen obtained after alcohol extraction in step 1, add notoginseng, add 5 times the amount of 40% ethanol for reflux extraction for 1.5 hours, filter; add 4 times the amount of 50% ethanol for the remaining medicinal residues, add 4 times the amount of 50% ethanol for reflux extraction for 1 hour, and filter , the extract is concentrated under reduced pressure and dried. Add water to dissolve until the sugar content is 48-52%, add ethanol to ...

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Abstract

The invention relates to a medicament for treating a coronary heart disease and extraction thereof. An extraction method comprises alcohol extraction of root of red-rooted salvia and notoginseng root, water extraction of the decoction dregs of the root of red-rooted salvia and notoginseng root, and other steps. The medicament has the advantages that: the process can realize industrialization, andthe quality is stable and controllable. Relevant tests prove that compared with the prior art, the medicament has good treatment effect, high purity and stable quality, can be absorbed well, and is novel in application; meanwhile, the preparation method of the medicament is simple, is convenient to operate, and is low in cost and suitable for industrial production.

Description

technical field [0001] The invention relates to a medicine for treating coronary heart disease, which belongs to the field of traditional Chinese medicine. Background technique [0002] With the improvement of living standards, the aging of the world's population and the rejuvenation of the disease population, cardiovascular and cerebrovascular patients are increasing year by year, and have become the second largest disease that endangers human health. Angina pectoris is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Coronary heart disease angina pectoris refers to angina pectoris caused by myocardial ischemia and hypoxia due to coronary artery sclerosis or spasm, accounting for about 90% of angina pectoris patients. [0003] The current methods of treating angina pectoris mainly focus on dilating blood vessels, reducing blood viscosity, anti-platelet aggregation, and anti-coag...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61P9/10A61K31/045
Inventor 刘顺航徐波戚可人刘岩陈红丛德刚赵国辉
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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