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Medicine or health-care food composition for treating atherosclerosis

A technology for atherosclerosis and health food, which is applied in the directions of drug combination, food preparation, and medical preparations containing active ingredients, etc.

Inactive Publication Date: 2013-07-17
CHENGDU HUAXI NATURAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is generally believed that non-genuine rhubarb should not be used as genuine rhubarb for medicinal purposes
At present, there is no report on the treatment of atherosclerosis with Tibetan rhubarb, nor the use of its active ingredient 3,5,3',4'-tetrahydroxystilbene-4'-O-β-D-glucoside Reports on the treatment of atherosclerosis

Method used

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  • Medicine or health-care food composition for treating atherosclerosis
  • Medicine or health-care food composition for treating atherosclerosis
  • Medicine or health-care food composition for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 The extraction method of Tibetan border rhubarb extract of the present invention

[0027] The preparation process of the rhubarb extract is as follows: take a certain amount of rhubarb medicinal material and crush it through a 20-mesh sieve, add an appropriate amount of 70% ethanol to soak for 24 hours, and elute with 5 times the column volume of 70% ethanol at a flow rate of 10ml min -1 , collect the eluate, and concentrate it to dryness under reduced pressure to obtain the rhubarb extract.

Embodiment 2

[0028] Embodiment 2 monomer compound 3,5,3', the preparation of 4'-tetrahydroxystilbene-4'-O-β-D-glucoside (PDG)

[0029] The separation and purification process of 3,5,3′,4′-tetrahydroxystilbene-4′-O-β-D-glucoside (PDG) in Rhubarb Zangbian is as follows: Rhubarb Zangbian is crushed and passed through 20 mesh Sieve, add 70% ethanol to soak for 24h, then add 10ml·min -1 Extract by percolation at a flow rate of 4 times the column volume and elute with 70% ethanol, collect the eluate, and concentrate it to an appropriate amount under reduced pressure. The concentrated solution was extracted 3 times with 5 times the volume of petroleum ether (boiling range 60-90°C), the residue in the water layer was collected, and then extracted 5 times with 1.5 times the volume of ethyl acetate to obtain ethyl acetate extract and water layer residue. Dissolve part of the ethyl acetate extract in a small amount of distilled water, weigh 100-200 mesh polyamide about 30 times the sample weight, a...

Embodiment 3

[0034] Example 3 Determination of content of the monomer compound 3,5,3',4'-tetrahydroxystilbene-4'-O-β-D-glucoside (PDG) in the rhubarb extract of the present invention

[0035] Preparation of Reference Substance Solution Accurately weigh an appropriate amount of pure 3,5,3′,4′-tetrahydroxystilbene-4′-O-β-D-glucoside, add methanol to prepare a solution containing about 0.4mg per 1ml solution as the reference solution.

[0036] Preparation of the test solution Take an appropriate amount of dry rhubarb extract, accurately weigh it, put it in a stoppered Erlenmeyer flask, add 25ml of methanol precisely, weigh it, ultrasonically treat it (150W, 40kHz) for 40min, let it cool, and then Weigh the weight, make up the lost weight with methanol, shake well, filter, and take the filtrate to obtain the test solution.

[0037] Chromatographic conditions and system adaptability conditions Octadecylsilane bonded silica gel is used as filler, the detection wavelength is 320nm, the mobile ph...

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PUM

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Abstract

The invention provides new application of rheum australe or extract thereof, in particular to application of the rheum australe or extract thereof in the preparation of medicine or health-care food for preventing or / and treating atherosclerosis. The invention also provides the new application of 3,5,3'4'-tetrahydroxy toluylene-4'-O-beta-D-glucoside which is a component of the rheum australe. The invention also provides a medicament or health-care food composition for treating atherosclerosis. By improving the endothelial function, inhibiting the aggregation of blood platelet, smooth muscle cell proliferation of blood vessels and the expression of adhesion molecules and blocking off the adhesive function between endothelial cells and mononuclear cell, the medicament or the health-care food composition for treating atherosclerosis has the function of reducing blood fat and preventing and treating the atherosclerosis.

Description

technical field [0001] The invention relates to a new application of Zangbian rhubarb or its extract, in particular, the application in the preparation of medicines for preventing and / or treating atherosclerosis. Background technique [0002] Rheum emodi Wall. is the root and rhizome of Rhubarb in the Polygonaceae family. It tastes sour, bitter, and cold in nature. It is mainly distributed in Tibet, Qinghai, Sichuan, and Yunnan, all of which are wild. Tibetan medicine is called Quza (Quza), which is used internally to treat gastroenteritis, and externally used to stop bleeding, treat sores, reduce inflammation, and heal wounds (Liu Bing, et al., Research on the Chemical Composition of Rhubarb from the Tibetan Border, "West China Pharmaceutical Journal", 22 in 2007 Volume 1 Issue). In recent years, it has been found that it has a good effect of lowering blood fat and blood sugar (Li Junlin, Wang Zhibin, Li Jiashi, Research on the hypoglycemic effect of Tibetan rhubarb. Chine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61K36/708A61P9/10A61P3/06A23L1/29A23L33/00
Inventor 王曙叶本贵冯莉王仁杰
Owner CHENGDU HUAXI NATURAL MEDICINE
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