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Cardiac or vascular patch with anticoagulant effect

An anti-coagulation and patch technology, applied in the field of medical material heart or blood vessel patch, can solve the problems of anti-coagulation modification, decreased mechanical properties of woven materials, and difficult to weave materials, and achieves the effect of excellent mechanical properties.

Active Publication Date: 2011-05-25
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a heart or blood vessel patch with an anticoagulant effect, which overcomes the defect that the existing polymer material anticoagulant modification method causes a substantial decrease in the mechanical properties of the heart or blood vessel patch braided material, It solves the technical problem that it is difficult to carry out anticoagulant modification on braided materials by grafting and blending methods. The method of the present invention carries out anticoagulant modification on braided materials for artificial blood vessels, while maintaining its excellent mechanical properties, softness and Obtain anti-coagulant effect at the same time of bending performance

Method used

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  • Cardiac or vascular patch with anticoagulant effect
  • Cardiac or vascular patch with anticoagulant effect
  • Cardiac or vascular patch with anticoagulant effect

Examples

Experimental program
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Effect test

Embodiment 1

[0032] A heart or blood vessel patch with an anticoagulant effect. The braided PA for artificial blood vessels is used as the base material, and phosphorylated modified nano-PU microspheres with a diameter of 100nm are embedded on the surface. The nano-PU microspheres are placed on the patch base. The concentration on the material is about 0.4mg / cm 2 .

[0033] The heart or blood vessel patch with anticoagulant effect is prepared as follows: 1 g of nano-PU microspheres with a diameter of 100 nm is placed in 200 mL of phosphate buffer solution with an ionic strength of 0.1 M and a pH value of 7 for 24 hours to achieve Its surface was phosphorylated; then 5 mg of nano-PU microspheres modified by surface phosphorylation were placed in 50 mL, and 0.1 mg / mL of PU ethanol solution was ultrasonically dispersed for 20 min to prepare surface phosphorylated modified nano-PU microspheres in PU ethanol. Suspension in the solution; finally, pour the suspension into a large centrifuge tube...

Embodiment 2

[0035] A heart or blood vessel patch with an anticoagulant effect, which uses braided PA for artificial blood vessels as the base material, and phosphorylated and modified nano-PU microspheres with a diameter of 300nm are embedded on the surface, and the nano-PU microspheres are placed on the base of the patch The concentration on the material is about 0.96mg / cm 2 .

[0036] The heart or blood vessel patch with anticoagulant effect is prepared by the following method: 1 g of nano-PU microspheres with a diameter of 300 nm is placed in 200 mL of phosphate buffer solution with an ionic strength of 0.1 M and a pH value of 7 for 24 hours to achieve Its surface was phosphorylated; then 12 mg of nano-PU microspheres modified by surface phosphorylation were placed in 50 mL, and 0.1 mg / mL of PU ethanol solution was ultrasonically dispersed for 20 min to prepare surface phosphorylated modified nano-PU microspheres in PU ethanol. Suspension in the solution; finally, pour the suspension ...

Embodiment 3

[0038] A heart or blood vessel patch with an anticoagulant effect. The braided PA for artificial blood vessels is used as the base material, and phosphorylated and modified nano-PU microspheres with a diameter of 200nm are embedded on the surface. The nano-PU microspheres are placed on the patch base The concentration on the material is about 0.48mg / cm 2 .

[0039]The heart or blood vessel patch with anticoagulant effect is prepared as follows: 1 g of nano-PU microspheres with a diameter of 200 nm is placed in 200 mL of phosphate buffer solution with an ionic strength of 0.1 M and a pH value of 7 for 24 hours to achieve Its surface was phosphorylated; then 6 mg of nano PU microspheres modified by surface phosphorylation were placed in 50 mL, and 0.1 mg / mL of PU ethanol solution was ultrasonically dispersed for 20 min to prepare surface phosphorylated modified nano PU microspheres in PU ethanol Suspension in the solution; finally, pour the suspension into a large centrifuge tu...

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Abstract

The invention discloses a cardiac or vascular patch with an anticoagulant effect. The surface of a substrate of the patch is modified on the surface of the woven polyamide (PA), polyethylene terephthalate (PET) or polytetrafluoroethylene (PTFE) substrate for artificial blood vessels by a coprecipitation method, and nanometer polyurethane (PU) microspheres of which the surfaces are modified by phosphorylation and which have the diameters of between 100 and 300nm into the surface of the substrate of the patch through a binder, namely polyurethane (PU), wherein the concentration of the nanometer PU microspheres is between 0.3 and 1.0mg / cm<2>. The cardiac or vascular patch has remarkable anticoagulant effect when keeping excellent mechanical properties, flexible performance and bending performance of the substrate of the patch.

Description

technical field [0001] The invention relates to a medical material heart or blood vessel patch, in particular to a heart or blood vessel patch with anticoagulant effect. Background technique [0002] Cardiac or vascular patches are medical materials often used in operations such as congenital heart disease. Cardiac patch is used to repair ventricular septal defect and ventricular wall repair and other ventricular diseases. It is also often used in the repair of atrial septal defect and other atrial diseases. It can be cut arbitrarily according to the defect situation, and the products are often cut Afterwards, it is used as a suture spacer for various operations. Vascular patches are used to repair fistulas of blood vessels caused by hemangiomas, vascular stenosis, etc. Vascular patches generally require the characteristics of easy suturing and hemostasis, and are generally used in large vessels such as the aorta. Although the human body's own material is the most ideal he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/00A61L27/34A61L33/06
Inventor 沈健黄晓华章峻袁江邵晓林
Owner NANJING NORMAL UNIVERSITY
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