Ophthalmic gel of artificial musk and preparation method thereof

An ophthalmic gel, artificial musk technology, applied in the field of medicine, can solve the problems of irritating patients' pain, practical use restrictions, waste of precious medicinal materials, etc.

Active Publication Date: 2011-06-01
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the ophthalmic preparations of musk or artificial musk reported publicly are to utilize the extract of musk, so that other active ingredients in the musk are likely to be discarded, causing a serious waste of precious medicinal material...

Method used

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  • Ophthalmic gel of artificial musk and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Prescription (prepared in 100g):

[0063] Artificial Musk 0.05%

[0064] Carbomer 943 0.05%

[0065] Hydroxypropyl Methyl Cellulose 50cp 0.1%

[0066] Tween 80 0.02%

[0067] Chlorobutanol 0.02%

[0068] Appropriate amount of sodium hydroxide

[0069] Appropriate amount of distilled water, add to 100%

[0070] Preparation Process:

[0071] (1) Take carbomer according to the dose, disperse it in a small amount of water, stir, and let it stand for 24 hours to fully swell the carbomer, sterilize at 121°C for 30 minutes, and set aside. Take hydroxypropyl methylcellulose according to the dosage, disperse it in a small amount of water at 80°C, stir evenly, pour a small amount of cold water, continue stirring evenly, and set aside.

[0072] (2) Mix the above carbomer aqueous solution and hydroxypropyl methylcellulose aqueous solution evenly, add an appropriate amount of sodium hydroxide, and adjust the pH to 7.0. Weigh the prescribed amount of chlorobutanol, dissolve i...

Embodiment 2

[0076] Prescription (prepared in 100g)

[0077] Artificial Musk 0.2%

[0078] Carbomer 980 0.2%

[0079] Polyoxyethylene 40 hydrogenated castor oil 0.1%

[0080] Benzalkonium Chloride 0.01%

[0081] Appropriate amount of sodium hydroxide

[0082] Appropriate amount of distilled water, add to 100%

[0083] Preparation Process:

[0084] (1) Take carbomer according to the dose, disperse it in a small amount of water, stir, and let it stand for 24 hours to fully swell the carbomer, sterilize at 121°C for 30 minutes, and set aside.

[0085] (2) Take the above carbomer aqueous solution, add an appropriate amount of sodium hydroxide, and adjust the pH to 6.8. Weigh the prescribed amount of benzalkonium chloride, dissolve it with a small amount of water, add it to the matrix aqueous solution, and stir evenly to obtain a gel matrix.

[0086] (3) The drug is pulverized into ultrafine powder by jet crushing method, passed through a 200-mesh sieve, and the prescribed amount of poly...

Embodiment 3

[0089] Prescription (prepared in 100g)

[0090] Artificial Musk 0.5%

[0091] Carbomer 941 0.4%

[0092] Polyvinyl alcohol 1.4%

[0093] Polyoxyethylene 40 hydrogenated castor oil 0.3%

[0094] Benzalkonium Chloride 0.01%

[0095] Appropriate amount of sodium hydroxide

[0096] Appropriate amount of distilled water, add to 100%

[0097] Preparation Process:

[0098] (1) Take carbomer according to the dose, disperse it in a small amount of water, stir, and let it stand for 24 hours to fully swell the carbomer, sterilize at 121°C for 30 minutes, and set aside. Take polyvinyl alcohol according to the dosage, disperse it in a small amount of water, stir it magnetically in a water bath at 80°C for 2 hours, and let it cool for later use.

[0099] (2) Mix the above carbomer aqueous solution and polyvinyl alcohol aqueous solution evenly, add an appropriate amount of sodium hydroxide, and adjust the pH to 6.8. Weigh the prescribed amount of benzalkonium chloride, dissolve it wi...

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PUM

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Abstract

The invention relates to ophthalmic gel of artificial musk and a preparation method thereof, in particular to ophthalmic gel. The ophthalmic gel contains artificial musk, a gel substrate agent, a surface active agent and water in effective dose for treatment. The invention also relates to an ophthalmic preparation which contains the ophthalmic gel disclosed by the invention and pharmaceutical excipient which is mixed with the ophthalmic gel before use and a preparation method of the ophthalmic gel. Discovered by the invention, the ophthalmic gel which is prepared by fully pulverizing artificial musk powder and contains a gel substrate and the surface active agent not only has favorable effect on treating eye diseases but also has less irritation on eyes.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a gel used for reducing inflammation and detumescence in the eyes, in particular to an ophthalmic gel made by adopting modern advanced technology and using artificial musk of precious traditional Chinese medicine as the main ingredient and its preparation method. Background technique [0002] Natural musk comes from the secretion of the subumbilical scent glands of mature male musk deer (Moschus berezovskii Flerov), horse musk deer (M.sifanicus Przewalski) or original musk deer (M.moschiferus Linnaeus), which is reddish brown after drying to dark brown granular material. Mainly produced in my country's Yunnan, Tibet, Sichuan and other places. Warm in nature and pungent in taste, returns to the spleen meridian, has the effects of resuscitating the mind, promoting blood circulation and stimulating menstrual flow, reducing swelling and relieving pain. This product is a commonly us...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/122A61K47/32A61K47/34A61K47/38A61P27/02A61K47/10
Inventor 刘继东唐海杨宇春李欣
Owner SHENYANG XINGQI PHARM CO LTD
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