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Method for synthesizing amine by catalytically reducing nitro compound by supported gold

A nitro compound, supported technology, applied in the field of chemistry, can solve the problems of easily polluted products, low cost, high toxicity of selenium powder, etc., and achieve the effects of environmental friendliness, low reaction corrosion, and light three waste treatment burden

Inactive Publication Date: 2011-06-08
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These methods are relatively low in cost, and the catalyst can be recycled, but the selenium powder is highly toxic and easily pollutes the product, so it is not suitable for use in the production of pharmaceutical intermediates

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1mmol nitrobenzene, 100mg1.5%wt Au / CeO 2 Catalyst, 10mL water, 10mL ethanol, the autoclave temperature is 30 ℃, then after replacing the air in the autoclave with CO, pass into 0.5MPa CO, stir for 10h, and the conversion rate of nitrobenzene into aniline is analyzed by gas chromatography. 99.8% with a selectivity of 99%.

Embodiment 2

[0021] 1mmol nitrobenzene, 100mg1.5%wt Au / TiO 2 Catalyst, 20mL water, the autoclave temperature is 30 ℃, then after replacing the air in the autoclave with CO, feed into 0.5MPa CO, stir for 12h, the conversion rate of nitrobenzene into aniline is 99.4% by gas chromatography analysis results, The selectivity is 99%.

Embodiment 3

[0023] 1mmol nitrobenzene, 100mg 1%wt Au / CeO were charged into a 100mL stainless steel autoclave 2 Catalyst, 10mL of water, 10mL of ethanol, the temperature of the autoclave is 30 °C, and then the air in the autoclave is replaced with CO, then 0.1MPa CO is introduced, stirred for 13h, and the conversion rate of nitrobenzene into aniline is analyzed by gas chromatography. 99.3% with a selectivity of 99%.

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PUM

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Abstract

The invention belongs to the chemical field, and particularly relates to a method for catalytically reducing nitro compound by using carbon monoxide and water as hydrogen sources and supported gold as catalyst. In the method of the invention, the nitro compound is used as substrate in the presence of carbon monoxide and water, the supported gold is used as catalyst, proper cosolvent is added into water phase or water phase system and the corresponding amine is prepared under the temperature of 30 to 50 DEG C. And the nitro compound can be either aliphatic nitro compound or aromatic compound, wherein a substituent group can be formed on the aromatic nitro compound and also can not be formed on, and the substituent groups can be one kind or several kinds of electron-donating base groups and / or electro-attracting base groups. The method has the advantages of easy operation, easily available raw materials, less pollution and high yield, and the catalysts can be easily separated, recovered and recycled.

Description

technical field [0001] The invention belongs to the field of chemistry, and relates to a method for supporting gold to catalyze the reduction of nitro compounds, and uses the method to prepare amines. Specifically, it relates to a method for catalytically reducing nitro compounds by using carbon monoxide and water as hydrogen sources and supported gold as a catalyst. Background technique [0002] The reduction of nitro compounds to amines is a very important reaction in fine chemicals and an important intermediate step in the synthesis of high value-added products such as drugs, spices, and food additives. The traditional reduction method mostly uses metered reducing agent, the product quality is not high, the material consumption and energy consumption are high, and the environmental problems are severe. The use of clean reducing agents, high-performance solid catalysts, and environmentally friendly green solvent systems has become an important research direction in the pu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07B43/04C07C211/46C07C209/36C07C211/52C07C225/22C07C221/00C07D215/38C07C225/34C07C211/35B01J23/66B01J23/52
Inventor 曹勇何林倪吉
Owner FUDAN UNIV
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