Sterile ultrasound coupling agent for invasive ultrasound diagnosis and treatment and preparation method thereof

An ultrasonic coupling agent and sterilizing technology, which is applied in the direction of echo/ultrasonic imaging agent, etc., can solve the problems that the ultrasonic probe cannot reach the disinfection level, violates the requirements for the use of medical equipment, and does not have the function of disinfection and sterilization, and achieves effective and wide-ranging Spectrum killing, reducing the risk of cross-infection, and the effect of rapid and efficient killing

Active Publication Date: 2012-07-18
武汉耦合医学科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing medical ultrasonic coupling agents generally do not have the function of disinfection and sterilization, which leads to the failure of the ultrasonic probe to reach the disinfection level, which violates the national requirements for the use of medical devices in hospitals.
Moreover, in the clinical application of medical ultrasound, there are still the following technical defects: 1. The traditional medical ultrasonic coupling agent only isolates the air and has no sterilization effect; 2. Most disinfectants are corrosive to the ultrasonic probe and cannot be used for disinfection ;3. Because the operating frequency of B-ultrasound is too high, the shorter the disinfection time of the ultrasonic probe, the better, usually about 1 minute
[0004] Although there are a few disinfectant medical ultrasonic coupling agents, their single disinfectant formula is difficult to kill pathogenic microorganisms in about 1 minute
More importantly, due to the limited bactericidal spectrum of a single bactericide component and the fact that the finished product is not thoroughly sterilized, there are still other pathogenic microorganisms in these coupling agents, so they are only suitable for medical ultrasound on intact skin It is not suitable for the examination of mucous membranes or non-intact mucosa, non-intact skin and invasive medical ultrasound practice
Even individual sterile-grade sterile medical ultrasound coupling agents can be used in invasive medical ultrasound practice, but the single bactericide in its formula only has disinfection effect, but has no hemostatic and wound healing effects, and is not completely effective. Facilitating invasive medical ultrasound practice

Method used

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  • Sterile ultrasound coupling agent for invasive ultrasound diagnosis and treatment and preparation method thereof
  • Sterile ultrasound coupling agent for invasive ultrasound diagnosis and treatment and preparation method thereof
  • Sterile ultrasound coupling agent for invasive ultrasound diagnosis and treatment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Prepare a sterile grade sterilized medical ultrasonic coupling agent for invasive ultrasonic diagnosis and treatment with a total weight of 1000 grams:

[0045] In the first step, 0.1 gram of 2,4,4'-trichloro-2'-hydroxyl diphenyl ether was dissolved in 40 grams of glycerol and allowed to stand for 12 hours;

[0046] In the second step, 6 grams of cross-linked polyacrylic resin and 5 grams of hydroxyethyl cellulose are dissolved in 250 grams of distilled water to obtain a mixed solution of cross-linked polyacrylic resin and hydroxyethyl cellulose;

[0047] In the third step, 100 grams of hydroxyethyl chitosan and 1 gram of triethanolamine are dissolved in 200 grams of distilled water;

[0048]The 4th step, the glycerol solution containing 2,4,4'-trichloro-2'-hydroxyl diphenyl ether obtained in the first step is added under stirring the cross-linked polyacrylic resin obtained in the second step and In the mixed solution of hydroxyethyl cellulose, continue to stir for 5 m...

Embodiment 2

[0077] Prepare a sterile grade sterilized medical ultrasonic coupling agent for invasive ultrasonic diagnosis and treatment with a total weight of 1000 grams:

[0078] In the first step, 2 grams of 2,4,4'-trichloro-2'-hydroxyl diphenyl ether was dissolved in 70 grams of glycerol and 30 grams of propylene glycol, and allowed to stand for 10 hours;

[0079] In the second step, 10 grams of cross-linked polyacrylic resin and 5 grams of hydroxypropyl cellulose are dissolved in 350 grams of distilled water to obtain a mixed solution of cross-linked polyacrylic resin and hydroxypropyl cellulose;

[0080] In the third step, 150 gram carboxymethyl chitosan and 5 gram triethanolamine are dissolved in 300 gram distilled water;

[0081] The fourth step is to add the glycerol and propylene glycol solution containing 2,4,4'-trichloro-2'-hydroxydiphenyl ether obtained in the first step into the cross-linked polyacrylic resin obtained in the second step under stirring In the mixed solution o...

Embodiment 3

[0107] Prepare a sterile grade sterilized medical ultrasonic coupling agent for invasive ultrasonic diagnosis and treatment with a total weight of 1000 grams:

[0108] The first step is to dissolve 5 grams of polyhexamethylene biguanide in 100 grams of distilled water and let it stand for 12 hours;

[0109] In the second step, 10 grams of cross-linked polyacrylic resin and 5 grams of hydroxyethyl cellulose are dissolved in 250 grams of distilled water to obtain a mixed solution of cross-linked polyacrylic resin and hydroxyethyl cellulose;

[0110] In the third step, 100 gram carboxymethyl chitosan and 10 gram triethanolamine are dissolved in 300 gram distilled water;

[0111] The fourth step is to add the polyhexamethylene biguanide solution obtained in the first step into the mixed solution of cross-linked polyacrylic acid resin and hydroxyethyl cellulose obtained in the second step under stirring, and continue to stir for 30 minutes, press Distilled water to make up the bal...

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Abstract

The invention relates to a sterile ultrasound gel for invasive ultrasound diagnosis and treatment and a preparation method thereof. The gel comprises the following components in percentage by weight: 0.01 to 0.5 percent of halogenated diphenyl ether or biguanide bactericides, 0.5 to 15 percent of water-soluble chitosan, 0 to 7 percent of dissolving agent, 0.5 to 1.5 percent of water-soluble polymer material, 0.1 to 1 percent of triethanolamine, and the balance of distilled water. The preparation of the sterile ultrasound gel comprises the following steps of: dissolving the halogenated diphenyl ether or the biguanide bactericides into partial distilled water, and standing for 1 to 15 hours; dissolving the water-soluble polymer material into the distilled water to obtain solution, and then dissolving the water-soluble chitosan and the triethanolamine into the distilled water to obtain solution; and adding solution of bactericides into the solution of water-soluble polymer material with stirring, then continuing stirring for 5 to 30 minutes, supplementing the residual distilled water, and then adding the solution of water-soluble chitosan and triethanolamine to obtain the sterile ultrasound gel. The sterile ultrasound gel has the effects of quick broad-spectrum sterilization, stopping bleeding and promoting wound healing, and is more applicable to clinical invasive ultrasound diagnosis and treatment practice.

Description

technical field [0001] The invention relates to a medical ultrasonic coupling agent and a preparation method thereof, in particular to a bactericidal medical ultrasonic coupling agent for invasive medical ultrasonic diagnosis and treatment and a preparation method thereof. Background technique [0002] Medical ultrasonic coupling agent is a sound-transmitting medium widely used in medical ultrasonic diagnosis and treatment at present. Its function is to strengthen the coupling between the ultrasonic probe and human skin, isolate the air between the ultrasonic probe and the skin of the examined part, and make the sound wave conduction unaffected. Attenuated by the influence of air to achieve accurate and clear inspection results. [0003] Since the ultrasonic probe is in contact with the body skin or cavity mucous membrane of the subject, the disinfection treatment of the ultrasonic probe itself becomes very important. However, the existing medical ultrasonic coupling agents...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22
Inventor 官培龙邹伟黄利苹谭伟
Owner 武汉耦合医学科技有限责任公司
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