Chitosan collagen gel and application thereof

Abstract

The invention relates to a chitosan collagen gel and an application thereof, and the gel comprises 1-15% of chitosan, 1-20% of collagen, 0.1-1% of gel matrix and water, wherein the chitosan is water-soluble chitosan with the molecular weight of 1500 Daltons-0.4 million Daltons, the molecular weight of the collagen is 5000 Daltons-3 million Daltons; and the gel matrix is selected from one or two of carbomer, polyethylene type and cellulose derivatives. The chitosan collagen gel is applied in hemostasis of acute and chronic wounds, absorption of seepage, autolytic debridement, protection of exposed nerve endings and pain relief, and can be simultaneously used for keeping moist environment of the wounds, accelerating the healing of the wounds and inhibiting scar formation.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, in particular to a chitosan collagen gel and its application. Background technique [0002] Since the human body has a complete repair mechanism for wounds, many minor wounds can be repaired and healed by their own repair mechanism only by protecting the wound surface from infection. However, for wounds such as skin harvesting areas, II and III degree burns, chronic ulcers, and surgical operations, the healing period is long, which brings great pain to patients, and the scars left after healing have become the most troublesome problem for people. In order to solve such problems, many wound dressings have emerged, but most of them are synthetic materials, such as silicone rubber materials, nylon materials, polypropylene materials, etc. After a period of application, people gradually found that synthetic materials have poor tissue compatibility. , the treatment effect is unsatisfactory. Howeve...

AI Technical Summary

Problems solved by technology

In recent years, due to the in-depth clinical research, some natural materials have also exposed some problems in use: such as the structural characteristics of collagen sponges, the wound tissue is easy to grow into the pores of the sponge, making it difficult to remove the membrane, and it is easy to leave the sponge on the wound. Foam debris increases scars; another example is that the water insolubility of chitosan limits its use in preparations, which seriously affects its popularization and application

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